Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FADS3 (fatty acid desaturase 3)

Identity

Alias_namesLLCDL3
Alias_symbol (synonym)CYB5RP
Other alias
HGNC (Hugo) FADS3
LocusID (NCBI) 3995
Atlas_Id 62972
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 61873523 and ends at 61891545 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1G1 (15q22.31) / FADS3 (11q12.2)MAML3 (4q31.1) / FADS3 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FADS3   3576
Cards
Entrez_Gene (NCBI)FADS3  3995  fatty acid desaturase 3
AliasesCYB5RP; LLCDL3
GeneCards (Weizmann)FADS3
Ensembl hg19 (Hinxton)ENSG00000221968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221968 [Gene_View]  ENSG00000221968 [Sequence]  chr11:61873523-61891545 [Contig_View]  FADS3 [Vega]
ICGC DataPortalENSG00000221968
TCGA cBioPortalFADS3
AceView (NCBI)FADS3
Genatlas (Paris)FADS3
WikiGenes3995
SOURCE (Princeton)FADS3
Genetics Home Reference (NIH)FADS3
Genomic and cartography
GoldenPath hg38 (UCSC)FADS3  -     chr11:61873523-61891545 -  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FADS3  -     11q12.2   [Description]    (hg19-Feb_2009)
GoldenPathFADS3 - 11q12.2 [CytoView hg19]  FADS3 - 11q12.2 [CytoView hg38]
ImmunoBaseENSG00000221968
Mapping of homologs : NCBIFADS3 [Mapview hg19]  FADS3 [Mapview hg38]
OMIM606150   
Gene and transcription
Genbank (Entrez)AB209356 AF084560 AF134404 AK091608 AK295473
RefSeq transcript (Entrez)NM_021727
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FADS3
Cluster EST : UnigeneHs.21765 [ NCBI ]
CGAP (NCI)Hs.21765
Alternative Splicing GalleryENSG00000221968
Gene ExpressionFADS3 [ NCBI-GEO ]   FADS3 [ EBI - ARRAY_EXPRESS ]   FADS3 [ SEEK ]   FADS3 [ MEM ]
Gene Expression Viewer (FireBrowse)FADS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3995
GTEX Portal (Tissue expression)FADS3
Human Protein AtlasENSG00000221968-FADS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5Q0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5Q0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5Q0
Splice isoforms : SwissVarQ9Y5Q0
Catalytic activity : Enzyme1.14.19.3 [ Enzyme-Expasy ]   1.14.19.31.14.19.3 [ IntEnz-EBI ]   1.14.19.3 [ BRENDA ]   1.14.19.3 [ KEGG ]   
PhosPhoSitePlusQ9Y5Q0
Domaine pattern : Prosite (Expaxy)CYTOCHROME_B5_2 (PS50255)   
Domains : Interpro (EBI)Cyt_B5-like_heme/steroid-bd    Cyt_B5-like_heme/steroid_sf    FA_desaturase_dom    Fatty_acid_desaturase   
Domain families : Pfam (Sanger)Cyt-b5 (PF00173)    FA_desaturase (PF00487)   
Domain families : Pfam (NCBI)pfam00173    pfam00487   
Domain families : Smart (EMBL)Cyt-b5 (SM01117)  
Conserved Domain (NCBI)FADS3
DMDM Disease mutations3995
Blocks (Seattle)FADS3
SuperfamilyQ9Y5Q0
Human Protein Atlas [tissue]ENSG00000221968-FADS3 [tissue]
Peptide AtlasQ9Y5Q0
HPRD07547
IPIIPI00028040   IPI00922814   IPI00556443   IPI00978189   IPI00980633   IPI00980348   IPI00982107   IPI00978788   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5Q0
IntAct (EBI)Q9Y5Q0
FunCoupENSG00000221968
BioGRIDFADS3
STRING (EMBL)FADS3
ZODIACFADS3
Ontologies - Pathways
QuickGOQ9Y5Q0
Ontology : AmiGOmolecular_function  endoplasmic reticulum membrane  unsaturated fatty acid biosynthetic process  unsaturated fatty acid biosynthetic process  membrane  integral component of membrane  oxidoreductase activity  oxidation-reduction process  
Ontology : EGO-EBImolecular_function  endoplasmic reticulum membrane  unsaturated fatty acid biosynthetic process  unsaturated fatty acid biosynthetic process  membrane  integral component of membrane  oxidoreductase activity  oxidation-reduction process  
Pathways : KEGGLinoleic acid metabolism   
NDEx NetworkFADS3
Atlas of Cancer Signalling NetworkFADS3
Wikipedia pathwaysFADS3
Orthology - Evolution
OrthoDB3995
GeneTree (enSembl)ENSG00000221968
Phylogenetic Trees/Animal Genes : TreeFamFADS3
HOGENOMQ9Y5Q0
Homologs : HomoloGeneFADS3
Homology/Alignments : Family Browser (UCSC)FADS3
Gene fusions - Rearrangements
Fusion : QuiverFADS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFADS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FADS3
dbVarFADS3
ClinVarFADS3
1000_GenomesFADS3 
Exome Variant ServerFADS3
ExAC (Exome Aggregation Consortium)ENSG00000221968
GNOMAD BrowserENSG00000221968
Varsome BrowserFADS3
Genetic variants : HAPMAP3995
Genomic Variants (DGV)FADS3 [DGVbeta]
DECIPHERFADS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFADS3 
Mutations
ICGC Data PortalFADS3 
TCGA Data PortalFADS3 
Broad Tumor PortalFADS3
OASIS PortalFADS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFADS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFADS3
Mutations and Diseases : HGMDFADS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FADS3
DgiDB (Drug Gene Interaction Database)FADS3
DoCM (Curated mutations)FADS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FADS3 (select a term)
intoGenFADS3
Cancer3DFADS3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606150   
Orphanet
DisGeNETFADS3
MedgenFADS3
Genetic Testing Registry FADS3
NextProtQ9Y5Q0 [Medical]
TSGene3995
GENETestsFADS3
Target ValidationFADS3
Huge Navigator FADS3 [HugePedia]
snp3D : Map Gene to Disease3995
BioCentury BCIQFADS3
ClinGenFADS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3995
Chemical/Pharm GKB GenePA27975
Clinical trialFADS3
Miscellaneous
canSAR (ICR)FADS3 (select the gene name)
DataMed IndexFADS3
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFADS3
EVEXFADS3
GoPubMedFADS3
iHOPFADS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Sep 3 15:27:15 CEST 2019
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