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FAF1 (Fas associated factor 1)

Identity

Alias (NCBI)CGI-03
HFAF1s
UBXD12
UBXN3A
hFAF1
HGNC (Hugo) FAF1
HGNC Alias symbCGI-03
hFAF1
HFAF1s
UBXD12
UBXN3A
HGNC Alias nameTNFRSF6-associated factor 1
 UBX domain protein 3A
HGNC Previous nameFas (TNFRSF6) associated factor 1
LocusID (NCBI) 11124
Atlas_Id 43250
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 50437028 and ends at 50960267 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGBL4 (1p33) / FAF1 (1p32.3)ELAVL4 (1p33) / FAF1 (1p32.3)FAF1 (1p32.3) / AGBL4 (1p33)
FAF1 (1p32.3) / DCAF6 (1q24.2)FAF1 (1p32.3) / EPS15 (1p32.3)FAF1 (1p32.3) / FAF1 (1p32.3)
FAF1 (1p32.3) / HCRTR1 (1p35.2)FAF1 (1p32.3) / HOOK1 (1p32.1)FAF1 (1p32.3) / LRRC7 (1p31.1)
FAF1 (1p32.3) / NFIA (1p31.3)FAF1 (1p32.3) / PTRH2 (17q23.1)FAF1 (1p32.3) / RCAN2 (6p21.1)
GABRB3 (15q12) / FAF1 (1p32.3)HAUS8 (19p13.11) / FAF1 (1p32.3)MACF1 (1p34.3) / FAF1 (1p32.3)
NUP133 (1q42.13) / FAF1 (1p32.3)RCAN2 (6p21.1) / FAF1 (1p32.3)RNF11 (1p32.3) / FAF1 (1p32.3)
SLC2A1 (1p34.2) / FAF1 (1p32.3)SORT1 (1p13.3) / FAF1 (1p32.3)TAF4 (20q13.33) / FAF1 (1p32.3)
AGBL4 1p33 / FAF1 1p32.3FAF1 1p32.3 / DCAF6 1q24.2FAF1 1p32.3 / HCRTR1 1p35.2
FAF1 1p32.3 / HOOK1 1p32.1FAF1 1p32.3 / LRRC7 1p31.1FAF1 1p32.3 / NFIA 1p31.3
FAF1 1p32.3 / PTRH2 17q23.1MACF1 1p34.3 / FAF1 1p32.3TAF4 20q13.33 / FAF1 1p32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FAF1   3578
Cards
Entrez_Gene (NCBI)FAF1    Fas associated factor 1
AliasesCGI-03; HFAF1s; UBXD12; UBXN3A; 
hFAF1
GeneCards (Weizmann)FAF1
Ensembl hg19 (Hinxton)ENSG00000185104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185104 [Gene_View]  ENSG00000185104 [Sequence]  chr1:50437028-50960267 [Contig_View]  FAF1 [Vega]
ICGC DataPortalENSG00000185104
TCGA cBioPortalFAF1
AceView (NCBI)FAF1
Genatlas (Paris)FAF1
SOURCE (Princeton)FAF1
Genetics Home Reference (NIH)FAF1
Genomic and cartography
GoldenPath hg38 (UCSC)FAF1  -     chr1:50437028-50960267 -  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAF1  -     1p32.3   [Description]    (hg19-Feb_2009)
GoldenPathFAF1 - 1p32.3 [CytoView hg19]  FAF1 - 1p32.3 [CytoView hg38]
ImmunoBaseENSG00000185104
Genome Data Viewer NCBIFAF1 [Mapview hg19]  
OMIM604460   
Gene and transcription
Genbank (Entrez)AF094700 AF106798 AF132938 AF136173 AJ271408
RefSeq transcript (Entrez)NM_007051 NM_131917
Consensus coding sequences : CCDS (NCBI)FAF1
Gene ExpressionFAF1 [ NCBI-GEO ]   FAF1 [ EBI - ARRAY_EXPRESS ]   FAF1 [ SEEK ]   FAF1 [ MEM ]
Gene Expression Viewer (FireBrowse)FAF1 [ Firebrowse - Broad ]
GenevisibleExpression of FAF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11124
GTEX Portal (Tissue expression)FAF1
Human Protein AtlasENSG00000185104-FAF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNN5
PhosPhoSitePlusQ9UNN5
Domaine pattern : Prosite (Expaxy)UBX (PS50033)   
Domains : Interpro (EBI)FAF1-like_UBX    Thioredoxin-like_sf    UAS    Ubiquitin-like_domsf    UBX_dom   
Domain families : Pfam (Sanger)UBX (PF00789)   
Domain families : Pfam (NCBI)pfam00789   
Domain families : Smart (EMBL)UAS (SM00594)  UBX (SM00166)  
Conserved Domain (NCBI)FAF1
PDB (RSDB)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB Europe1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB (PDBSum)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB (IMB)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
Structural Biology KnowledgeBase1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
SCOP (Structural Classification of Proteins)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
CATH (Classification of proteins structures)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
SuperfamilyQ9UNN5
AlphaFold pdb e-kbQ9UNN5   
Human Protein Atlas [tissue]ENSG00000185104-FAF1 [tissue]
HPRD05124
Protein Interaction databases
DIP (DOE-UCLA)Q9UNN5
IntAct (EBI)Q9UNN5
BioGRIDFAF1
STRING (EMBL)FAF1
ZODIACFAF1
Ontologies - Pathways
QuickGOQ9UNN5
Ontology : AmiGOprotein binding  nucleus  nuclear envelope  nucleoplasm  cytosol  apoptotic process  cytoplasmic sequestering of NF-kappaB  cell death  positive regulation of cell death  protein kinase regulator activity  protein kinase binding  protein domain specific binding  regulation of cell adhesion  heat shock protein binding  CD95 death-inducing signaling complex  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  VCP-NPL4-UFD1 AAA ATPase complex  regulation of protein catabolic process  positive regulation of apoptotic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of DNA replication  regulation of protein kinase activity  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of cellular protein catabolic process  
Ontology : EGO-EBIprotein binding  nucleus  nuclear envelope  nucleoplasm  cytosol  apoptotic process  cytoplasmic sequestering of NF-kappaB  cell death  positive regulation of cell death  protein kinase regulator activity  protein kinase binding  protein domain specific binding  regulation of cell adhesion  heat shock protein binding  CD95 death-inducing signaling complex  positive regulation of protein-containing complex assembly  ubiquitin protein ligase binding  VCP-NPL4-UFD1 AAA ATPase complex  regulation of protein catabolic process  positive regulation of apoptotic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of DNA replication  regulation of protein kinase activity  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of cellular protein catabolic process  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]   
NDEx NetworkFAF1
Atlas of Cancer Signalling NetworkFAF1
Wikipedia pathwaysFAF1
Orthology - Evolution
OrthoDB11124
GeneTree (enSembl)ENSG00000185104
Phylogenetic Trees/Animal Genes : TreeFamFAF1
Homologs : HomoloGeneFAF1
Homology/Alignments : Family Browser (UCSC)FAF1
Gene fusions - Rearrangements
Fusion : MitelmanAGBL4/FAF1 [1p33/1p32.3]  
Fusion : MitelmanFAF1/DCAF6 [1p32.3/1q24.2]  
Fusion : MitelmanFAF1/HCRTR1 [1p32.3/1p35.2]  
Fusion : MitelmanFAF1/HOOK1 [1p32.3/1p32.1]  
Fusion : MitelmanFAF1/LRRC7 [1p32.3/1p31.1]  
Fusion : MitelmanFAF1/NFIA [1p32.3/1p31.3]  
Fusion : MitelmanFAF1/PTRH2 [1p32.3/17q23.1]  
Fusion : MitelmanMACF1/FAF1 [1p34.3/1p32.3]  
Fusion : MitelmanSLC2A1/FAF1 [1p34.2/1p32.3]  
Fusion : MitelmanTAF4/FAF1 [20q13.33/1p32.3]  
Fusion : QuiverFAF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAF1
dbVarFAF1
ClinVarFAF1
MonarchFAF1
1000_GenomesFAF1 
Exome Variant ServerFAF1
GNOMAD BrowserENSG00000185104
Varsome BrowserFAF1
ACMGFAF1 variants
VarityQ9UNN5
Genomic Variants (DGV)FAF1 [DGVbeta]
DECIPHERFAF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAF1 
Mutations
ICGC Data PortalFAF1 
TCGA Data PortalFAF1 
Broad Tumor PortalFAF1
OASIS PortalFAF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFAF1
Mutations and Diseases : HGMDFAF1
intOGen PortalFAF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFAF1
DgiDB (Drug Gene Interaction Database)FAF1
DoCM (Curated mutations)FAF1
CIViC (Clinical Interpretations of Variants in Cancer)FAF1
Cancer3DFAF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604460   
Orphanet
DisGeNETFAF1
MedgenFAF1
Genetic Testing Registry FAF1
NextProtQ9UNN5 [Medical]
GENETestsFAF1
Target ValidationFAF1
Huge Navigator FAF1 [HugePedia]
ClinGenFAF1
Clinical trials, drugs, therapy
MyCancerGenomeFAF1
Protein Interactions : CTDFAF1
Pharm GKB GenePA27976
PharosQ9UNN5
Clinical trialFAF1
Miscellaneous
canSAR (ICR)FAF1
HarmonizomeFAF1
DataMed IndexFAF1
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFAF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:48 CEST 2021

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