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FAF1 (Fas associated factor 1)

Identity

Alias_namesFas (TNFRSF6) associated factor 1
Alias_symbol (synonym)CGI-03
hFAF1
HFAF1s
UBXD12
UBXN3A
Other alias
HGNC (Hugo) FAF1
LocusID (NCBI) 11124
Atlas_Id 43250
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 50906935 and ends at 51425936 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGBL4 (1p33) / FAF1 (1p32.3)ELAVL4 (1p33) / FAF1 (1p32.3)FAF1 (1p32.3) / AGBL4 (1p33)
FAF1 (1p32.3) / DCAF6 (1q24.2)FAF1 (1p32.3) / EPS15 (1p32.3)FAF1 (1p32.3) / FAF1 (1p32.3)
FAF1 (1p32.3) / HCRTR1 (1p35.2)FAF1 (1p32.3) / HOOK1 (1p32.1)FAF1 (1p32.3) / LRRC7 (1p31.1)
FAF1 (1p32.3) / NFIA (1p31.3)FAF1 (1p32.3) / PTRH2 (17q23.1)FAF1 (1p32.3) / RCAN2 (6p21.1)
GABRB3 (15q12) / FAF1 (1p32.3)HAUS8 (19p13.11) / FAF1 (1p32.3)MACF1 (1p34.3) / FAF1 (1p32.3)
NUP133 (1q42.13) / FAF1 (1p32.3)RCAN2 (6p21.1) / FAF1 (1p32.3)RNF11 (1p32.3) / FAF1 (1p32.3)
SLC2A1 (1p34.2) / FAF1 (1p32.3)SORT1 (1p13.3) / FAF1 (1p32.3)TAF4 (20q13.33) / FAF1 (1p32.3)
AGBL4 1p33 / FAF1 1p32.3FAF1 1p32.3 / DCAF6 1q24.2FAF1 1p32.3 / HCRTR1 1p35.2
FAF1 1p32.3 / HOOK1 1p32.1FAF1 1p32.3 / LRRC7 1p31.1FAF1 1p32.3 / NFIA 1p31.3
FAF1 1p32.3 / PTRH2 17q23.1MACF1 1p34.3 / FAF1 1p32.3TAF4 20q13.33 / FAF1 1p32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FAF1   3578
Cards
Entrez_Gene (NCBI)FAF1  11124  Fas associated factor 1
AliasesCGI-03; HFAF1s; UBXD12; UBXN3A; 
hFAF1
GeneCards (Weizmann)FAF1
Ensembl hg19 (Hinxton)ENSG00000185104 [Gene_View]  chr1:50906935-51425936 [Contig_View]  FAF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185104 [Gene_View]  chr1:50906935-51425936 [Contig_View]  FAF1 [Vega]
ICGC DataPortalENSG00000185104
TCGA cBioPortalFAF1
AceView (NCBI)FAF1
Genatlas (Paris)FAF1
WikiGenes11124
SOURCE (Princeton)FAF1
Genetics Home Reference (NIH)FAF1
Genomic and cartography
GoldenPath hg19 (UCSC)FAF1  -     chr1:50906935-51425936 -  1p32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FAF1  -     1p32.3   [Description]    (hg38-Dec_2013)
EnsemblFAF1 - 1p32.3 [CytoView hg19]  FAF1 - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBIFAF1 [Mapview hg19]  FAF1 [Mapview hg38]
OMIM604460   
Gene and transcription
Genbank (Entrez)AF094700 AF106798 AF132938 AF136173 AJ271408
RefSeq transcript (Entrez)NM_007051 NM_131917
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)FAF1
Cluster EST : UnigeneHs.530402 [ NCBI ]
CGAP (NCI)Hs.530402
Alternative Splicing GalleryENSG00000185104
Gene ExpressionFAF1 [ NCBI-GEO ]   FAF1 [ EBI - ARRAY_EXPRESS ]   FAF1 [ SEEK ]   FAF1 [ MEM ]
Gene Expression Viewer (FireBrowse)FAF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11124
GTEX Portal (Tissue expression)FAF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNN5
Splice isoforms : SwissVarQ9UNN5
PhosPhoSitePlusQ9UNN5
Domaine pattern : Prosite (Expaxy)UBX (PS50033)   
Domains : Interpro (EBI)FAF1    Thioredoxin-like_fold    UAS    Ubiquitin-rel_dom    UBX_dom   
Domain families : Pfam (Sanger)UBX (PF00789)   
Domain families : Pfam (NCBI)pfam00789   
Domain families : Smart (EMBL)UAS (SM00594)  UBX (SM00166)  
Conserved Domain (NCBI)FAF1
DMDM Disease mutations11124
Blocks (Seattle)FAF1
PDB (SRS)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB (PDBSum)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB (IMB)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
PDB (RSDB)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
Structural Biology KnowledgeBase1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
SCOP (Structural Classification of Proteins)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
CATH (Classification of proteins structures)1H8C    2DZM    2EC4    3E21    3QC8    3QCA    3QQ8    3QWZ    3QX1    3R3M   
SuperfamilyQ9UNN5
Human Protein AtlasENSG00000185104
Peptide AtlasQ9UNN5
HPRD05124
IPIIPI00070643   IPI00219265   IPI01014422   IPI01018870   IPI00844032   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNN5
IntAct (EBI)Q9UNN5
FunCoupENSG00000185104
BioGRIDFAF1
STRING (EMBL)FAF1
ZODIACFAF1
Ontologies - Pathways
QuickGOQ9UNN5
Ontology : AmiGOprotein binding  nucleus  nuclear envelope  cytosol  apoptotic process  cytoplasmic sequestering of NF-kappaB  cell death  positive regulation of cell death  protein kinase regulator activity  protein kinase binding  protein domain specific binding  regulation of cell adhesion  heat shock protein binding  CD95 death-inducing signaling complex  positive regulation of protein complex assembly  ubiquitin protein ligase binding  VCP-NPL4-UFD1 AAA ATPase complex  regulation of protein catabolic process  positive regulation of apoptotic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of protein kinase activity  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIprotein binding  nucleus  nuclear envelope  cytosol  apoptotic process  cytoplasmic sequestering of NF-kappaB  cell death  positive regulation of cell death  protein kinase regulator activity  protein kinase binding  protein domain specific binding  regulation of cell adhesion  heat shock protein binding  CD95 death-inducing signaling complex  positive regulation of protein complex assembly  ubiquitin protein ligase binding  VCP-NPL4-UFD1 AAA ATPase complex  regulation of protein catabolic process  positive regulation of apoptotic process  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of protein kinase activity  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]   
NDEx NetworkFAF1
Atlas of Cancer Signalling NetworkFAF1
Wikipedia pathwaysFAF1
Orthology - Evolution
OrthoDB11124
GeneTree (enSembl)ENSG00000185104
Phylogenetic Trees/Animal Genes : TreeFamFAF1
HOVERGENQ9UNN5
HOGENOMQ9UNN5
Homologs : HomoloGeneFAF1
Homology/Alignments : Family Browser (UCSC)FAF1
Gene fusions - Rearrangements
Fusion : MitelmanAGBL4/FAF1 [1p33/1p32.3]  [t(1;1)(p32;p33)]  
Fusion : MitelmanFAF1/DCAF6 [1p32.3/1q24.2]  [t(1;1)(p32;q24)]  
Fusion : MitelmanFAF1/HCRTR1 [1p32.3/1p35.2]  [t(1;1)(p32;p35)]  
Fusion : MitelmanFAF1/HOOK1 [1p32.3/1p32.1]  [t(1;1)(p32;p32)]  
Fusion : MitelmanFAF1/LRRC7 [1p32.3/1p31.1]  [t(1;1)(p31;p32)]  
Fusion : MitelmanFAF1/NFIA [1p32.3/1p31.3]  [t(1;1)(p31;p32)]  
Fusion : MitelmanFAF1/PTRH2 [1p32.3/17q23.1]  [t(1;17)(p32;q23)]  
Fusion : MitelmanMACF1/FAF1 [1p34.3/1p32.3]  [t(1;1)(p32;p34)]  
Fusion : MitelmanSLC2A1/FAF1 [1p34.2/1p32.3]  [t(1;1)(p32;p34)]  
Fusion : MitelmanTAF4/FAF1 [20q13.33/1p32.3]  [t(1;20)(p32;q13)]  
Fusion: TCGAAGBL4 1p33 FAF1 1p32.3 BRCA PRAD
Fusion: TCGAFAF1 1p32.3 DCAF6 1q24.2 LUAD
Fusion: TCGAFAF1 1p32.3 HCRTR1 1p35.2 BRCA
Fusion: TCGAFAF1 1p32.3 HOOK1 1p32.1 BRCA
Fusion: TCGAFAF1 1p32.3 LRRC7 1p31.1 BRCA
Fusion: TCGAFAF1 1p32.3 NFIA 1p31.3 BRCA
Fusion: TCGAFAF1 1p32.3 PTRH2 17q23.1 BRCA
Fusion: TCGAMACF1 1p34.3 FAF1 1p32.3 BRCA
Fusion: TCGATAF4 20q13.33 FAF1 1p32.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAF1
dbVarFAF1
ClinVarFAF1
1000_GenomesFAF1 
Exome Variant ServerFAF1
ExAC (Exome Aggregation Consortium)FAF1 (select the gene name)
Genetic variants : HAPMAP11124
Genomic Variants (DGV)FAF1 [DGVbeta]
DECIPHER (Syndromes)1:50906935-51425936  ENSG00000185104
CONAN: Copy Number AnalysisFAF1 
Mutations
ICGC Data PortalFAF1 
TCGA Data PortalFAF1 
Broad Tumor PortalFAF1
OASIS PortalFAF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAF1
intOGen PortalFAF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAF1
DgiDB (Drug Gene Interaction Database)FAF1
DoCM (Curated mutations)FAF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAF1 (select a term)
intoGenFAF1
Cancer3DFAF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604460   
Orphanet
MedgenFAF1
Genetic Testing Registry FAF1
NextProtQ9UNN5 [Medical]
TSGene11124
GENETestsFAF1
Huge Navigator FAF1 [HugePedia]
snp3D : Map Gene to Disease11124
BioCentury BCIQFAF1
ClinGenFAF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11124
Chemical/Pharm GKB GenePA27976
Clinical trialFAF1
Miscellaneous
canSAR (ICR)FAF1 (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAF1
EVEXFAF1
GoPubMedFAF1
iHOPFAF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:05:19 CET 2017

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