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FAIM2 (Fas apoptotic inhibitory molecule 2)

Identity

Alias_symbol (synonym)KIAA0950
LFG
NMP35
LIFEGUARD
TMBIM2
LFG2
Other aliasNGP35
HGNC (Hugo) FAIM2
LocusID (NCBI) 23017
Atlas_Id 43252
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49866896 and ends at 49903977 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAIM2 (12q13.12) / FAIM2 (12q13.12)FAIM2 (12q13.12) / PCNT (21q22.3)PBXIP1 (1q21.3) / FAIM2 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FAIM2   17067
Cards
Entrez_Gene (NCBI)FAIM2  23017  Fas apoptotic inhibitory molecule 2
AliasesLFG; LFG2; NGP35; NMP35; 
TMBIM2
GeneCards (Weizmann)FAIM2
Ensembl hg19 (Hinxton)ENSG00000135472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135472 [Gene_View]  chr12:49866896-49903977 [Contig_View]  FAIM2 [Vega]
ICGC DataPortalENSG00000135472
TCGA cBioPortalFAIM2
AceView (NCBI)FAIM2
Genatlas (Paris)FAIM2
WikiGenes23017
SOURCE (Princeton)FAIM2
Genetics Home Reference (NIH)FAIM2
Genomic and cartography
GoldenPath hg38 (UCSC)FAIM2  -     chr12:49866896-49903977 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAIM2  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblFAIM2 - 12q13.12 [CytoView hg19]  FAIM2 - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBIFAIM2 [Mapview hg19]  FAIM2 [Mapview hg38]
OMIM604306   
Gene and transcription
Genbank (Entrez)AB023167 AF190461 AK090728 AK290031 AL707764
RefSeq transcript (Entrez)NM_012306
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAIM2
Cluster EST : UnigeneHs.567424 [ NCBI ]
CGAP (NCI)Hs.567424
Alternative Splicing GalleryENSG00000135472
Gene ExpressionFAIM2 [ NCBI-GEO ]   FAIM2 [ EBI - ARRAY_EXPRESS ]   FAIM2 [ SEEK ]   FAIM2 [ MEM ]
Gene Expression Viewer (FireBrowse)FAIM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23017
GTEX Portal (Tissue expression)FAIM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BWQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BWQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BWQ8
Splice isoforms : SwissVarQ9BWQ8
PhosPhoSitePlusQ9BWQ8
Domains : Interpro (EBI)Bax_inhibitor_1-related   
Domain families : Pfam (Sanger)Bax1-I (PF01027)   
Domain families : Pfam (NCBI)pfam01027   
Conserved Domain (NCBI)FAIM2
DMDM Disease mutations23017
Blocks (Seattle)FAIM2
SuperfamilyQ9BWQ8
Human Protein AtlasENSG00000135472
Peptide AtlasQ9BWQ8
HPRD09184
IPIIPI00017569   IPI01022834   IPI01022940   IPI01022538   IPI01021208   IPI01021354   
Protein Interaction databases
DIP (DOE-UCLA)Q9BWQ8
IntAct (EBI)Q9BWQ8
FunCoupENSG00000135472
BioGRIDFAIM2
STRING (EMBL)FAIM2
ZODIACFAIM2
Ontologies - Pathways
QuickGOQ9BWQ8
Ontology : AmiGOresponse to ischemia  endoplasmic reticulum  Golgi apparatus  apoptotic process  integral component of membrane  cerebellum development  cerebellar Purkinje cell layer development  cerebellar granular layer development  cerebellar Purkinje cell differentiation  cell junction  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  membrane raft  postsynaptic membrane  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIresponse to ischemia  endoplasmic reticulum  Golgi apparatus  apoptotic process  integral component of membrane  cerebellum development  cerebellar Purkinje cell layer development  cerebellar granular layer development  cerebellar Purkinje cell differentiation  cell junction  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  membrane raft  postsynaptic membrane  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
NDEx NetworkFAIM2
Atlas of Cancer Signalling NetworkFAIM2
Wikipedia pathwaysFAIM2
Orthology - Evolution
OrthoDB23017
GeneTree (enSembl)ENSG00000135472
Phylogenetic Trees/Animal Genes : TreeFamFAIM2
HOVERGENQ9BWQ8
HOGENOMQ9BWQ8
Homologs : HomoloGeneFAIM2
Homology/Alignments : Family Browser (UCSC)FAIM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAIM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAIM2
dbVarFAIM2
ClinVarFAIM2
1000_GenomesFAIM2 
Exome Variant ServerFAIM2
ExAC (Exome Aggregation Consortium)FAIM2 (select the gene name)
Genetic variants : HAPMAP23017
Genomic Variants (DGV)FAIM2 [DGVbeta]
DECIPHERFAIM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAIM2 
Mutations
ICGC Data PortalFAIM2 
TCGA Data PortalFAIM2 
Broad Tumor PortalFAIM2
OASIS PortalFAIM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAIM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAIM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAIM2
DgiDB (Drug Gene Interaction Database)FAIM2
DoCM (Curated mutations)FAIM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAIM2 (select a term)
intoGenFAIM2
Cancer3DFAIM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604306   
Orphanet
MedgenFAIM2
Genetic Testing Registry FAIM2
NextProtQ9BWQ8 [Medical]
TSGene23017
GENETestsFAIM2
Target ValidationFAIM2
Huge Navigator FAIM2 [HugePedia]
snp3D : Map Gene to Disease23017
BioCentury BCIQFAIM2
ClinGenFAIM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23017
Chemical/Pharm GKB GenePA134879081
Clinical trialFAIM2
Miscellaneous
canSAR (ICR)FAIM2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAIM2
EVEXFAIM2
GoPubMedFAIM2
iHOPFAIM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:33:12 CEST 2017

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