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FAIM2 (Fas apoptotic inhibitory molecule 2)

Identity

Alias (NCBI)LFG
LFG2
NGP35
NMP35
TMBIM2
HGNC (Hugo) FAIM2
HGNC Alias symbKIAA0950
LFG
NMP35
LIFEGUARD
TMBIM2
LFG2
HGNC Alias nametransmembrane BAX inhibitor motif containing 2
LocusID (NCBI) 23017
Atlas_Id 43252
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49866896 and ends at 49903900 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAIM2 (12q13.12) / FAIM2 (12q13.12)FAIM2 (12q13.12) / PCNT (21q22.3)PBXIP1 (1q21.3) / FAIM2 (12q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FAIM2   17067
Cards
Entrez_Gene (NCBI)FAIM2    Fas apoptotic inhibitory molecule 2
AliasesLFG; LFG2; NGP35; NMP35; 
TMBIM2
GeneCards (Weizmann)FAIM2
Ensembl hg19 (Hinxton)ENSG00000135472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135472 [Gene_View]  ENSG00000135472 [Sequence]  chr12:49866896-49903900 [Contig_View]  FAIM2 [Vega]
ICGC DataPortalENSG00000135472
TCGA cBioPortalFAIM2
AceView (NCBI)FAIM2
Genatlas (Paris)FAIM2
SOURCE (Princeton)FAIM2
Genetics Home Reference (NIH)FAIM2
Genomic and cartography
GoldenPath hg38 (UCSC)FAIM2  -     chr12:49866896-49903900 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAIM2  -     12q13.12   [Description]    (hg19-Feb_2009)
GoldenPathFAIM2 - 12q13.12 [CytoView hg19]  FAIM2 - 12q13.12 [CytoView hg38]
ImmunoBaseENSG00000135472
Genome Data Viewer NCBIFAIM2 [Mapview hg19]  
OMIM604306   
Gene and transcription
Genbank (Entrez)AB023167 AF190461 AK090728 AK290031 AL707764
RefSeq transcript (Entrez)NM_012306
Consensus coding sequences : CCDS (NCBI)FAIM2
Gene ExpressionFAIM2 [ NCBI-GEO ]   FAIM2 [ EBI - ARRAY_EXPRESS ]   FAIM2 [ SEEK ]   FAIM2 [ MEM ]
Gene Expression Viewer (FireBrowse)FAIM2 [ Firebrowse - Broad ]
GenevisibleExpression of FAIM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23017
GTEX Portal (Tissue expression)FAIM2
Human Protein AtlasENSG00000135472-FAIM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BWQ8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BWQ8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BWQ8
PhosPhoSitePlusQ9BWQ8
Domains : Interpro (EBI)Bax_inhibitor_1-related   
Domain families : Pfam (Sanger)Bax1-I (PF01027)   
Domain families : Pfam (NCBI)pfam01027   
Conserved Domain (NCBI)FAIM2
SuperfamilyQ9BWQ8
AlphaFold pdb e-kbQ9BWQ8   
Human Protein Atlas [tissue]ENSG00000135472-FAIM2 [tissue]
HPRD09184
Protein Interaction databases
DIP (DOE-UCLA)Q9BWQ8
IntAct (EBI)Q9BWQ8
BioGRIDFAIM2
STRING (EMBL)FAIM2
ZODIACFAIM2
Ontologies - Pathways
QuickGOQ9BWQ8
Ontology : AmiGOresponse to ischemia  protein binding  endoplasmic reticulum  Golgi apparatus  apoptotic process  integral component of membrane  cerebellum development  cerebellar Purkinje cell layer development  cerebellar granular layer development  cerebellar Purkinje cell differentiation  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  membrane raft  postsynaptic membrane  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIresponse to ischemia  protein binding  endoplasmic reticulum  Golgi apparatus  apoptotic process  integral component of membrane  cerebellum development  cerebellar Purkinje cell layer development  cerebellar granular layer development  cerebellar Purkinje cell differentiation  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  membrane raft  postsynaptic membrane  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
NDEx NetworkFAIM2
Atlas of Cancer Signalling NetworkFAIM2
Wikipedia pathwaysFAIM2
Orthology - Evolution
OrthoDB23017
GeneTree (enSembl)ENSG00000135472
Phylogenetic Trees/Animal Genes : TreeFamFAIM2
Homologs : HomoloGeneFAIM2
Homology/Alignments : Family Browser (UCSC)FAIM2
Gene fusions - Rearrangements
Fusion : QuiverFAIM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAIM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAIM2
dbVarFAIM2
ClinVarFAIM2
MonarchFAIM2
1000_GenomesFAIM2 
Exome Variant ServerFAIM2
GNOMAD BrowserENSG00000135472
Varsome BrowserFAIM2
ACMGFAIM2 variants
VarityQ9BWQ8
Genomic Variants (DGV)FAIM2 [DGVbeta]
DECIPHERFAIM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAIM2 
Mutations
ICGC Data PortalFAIM2 
TCGA Data PortalFAIM2 
Broad Tumor PortalFAIM2
OASIS PortalFAIM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAIM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFAIM2
Mutations and Diseases : HGMDFAIM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFAIM2
DgiDB (Drug Gene Interaction Database)FAIM2
DoCM (Curated mutations)FAIM2
CIViC (Clinical Interpretations of Variants in Cancer)FAIM2
Cancer3DFAIM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604306   
Orphanet
DisGeNETFAIM2
MedgenFAIM2
Genetic Testing Registry FAIM2
NextProtQ9BWQ8 [Medical]
GENETestsFAIM2
Target ValidationFAIM2
Huge Navigator FAIM2 [HugePedia]
ClinGenFAIM2
Clinical trials, drugs, therapy
MyCancerGenomeFAIM2
Protein Interactions : CTDFAIM2
Pharm GKB GenePA134879081
PharosQ9BWQ8
Clinical trialFAIM2
Miscellaneous
canSAR (ICR)FAIM2
HarmonizomeFAIM2
DataMed IndexFAIM2
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFAIM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:48 CEST 2021

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