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FAM129B (family with sequence similarity 129 member B)

Identity

Alias_namesC9orf88
chromosome 9 open reading frame 88
family with sequence similarity 129, member B
Alias_symbol (synonym)DKFZP434H0820
FLJ13518
FLJ22151
FLJ22298
bA356B19.6
MINERVA
Other aliasMEG-3
OC58
HGNC (Hugo) FAM129B
LocusID (NCBI) 64855
Atlas_Id 50994
Location 9q34.11  [Link to chromosome band 9q34]
Location_base_pair Starts at 127505338 and ends at 127569117 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNN1 (19p13.2) / FAM129B (9q33.3)FAM129B (9q33.3) / AFF4 (5q31.1)FAM129B (9q33.3) / CLDN4 (7q11.23)
FAM129B (9q33.3) / CTSD (11p15.5)FAM129B (9q33.3) / EIF3H (8q23.3)FAM129B (9q33.3) / FAM129B (9q33.3)
FAM129B (9q33.3) / METRNL (17q25.3)FAM129B (9q33.3) / OLFM1 (9q34.3)FAM129B (9q33.3) / PYROXD1 (12p12.1)
FAM129B (9q33.3) / SEC16A (9q34.3)FAM129B (9q33.3) / ZER1 (9q34.11)SMCO4 (11q21) / FAM129B (9q33.3)
ZNF79 (9q33.3) / FAM129B (9q33.3)C11orf75 FAM129B 9q33.3CNN1 19p13.2 / FAM129B 9q33.3
FAM129B 9q33.3 / CLDN4 7q11.23FAM129B 9q33.3 / OLFM1 9q34.3FAM129B 9q33.3 / PYROXD1 12p12.1
FAM129B 9q33.3 / SEC16A 9q34.3ZNF79 9q33.3 / FAM129B 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(7;9)(q11;q34) FAM129B/CLDN4
t(9;9)(q33;q34) ZNF79/FAM129B
t(9;9)(q34;q34) FAM129B/OLFM1
t(9;9)(q34;q34) FAM129B/SEC16A
t(9;11)(q34;q21) SMCO4/FAM129B
t(9;12)(q34;p12) FAM129B/PYROXD1
t(9;19)(q34;p13) CNN1/FAM129B

External links

Nomenclature
HGNC (Hugo)FAM129B   25282
Cards
Entrez_Gene (NCBI)FAM129B  64855  family with sequence similarity 129 member B
AliasesC9orf88; MEG-3; MINERVA; OC58; 
bA356B19.6
GeneCards (Weizmann)FAM129B
Ensembl hg19 (Hinxton)ENSG00000136830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136830 [Gene_View]  ENSG00000136830 [Sequence]  chr9:127505338-127569117 [Contig_View]  FAM129B [Vega]
ICGC DataPortalENSG00000136830
TCGA cBioPortalFAM129B
AceView (NCBI)FAM129B
Genatlas (Paris)FAM129B
WikiGenes64855
SOURCE (Princeton)FAM129B
Genetics Home Reference (NIH)FAM129B
Genomic and cartography
GoldenPath hg38 (UCSC)FAM129B  -     chr9:127505338-127569117 -  9q34.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAM129B  -     9q34.11   [Description]    (hg19-Feb_2009)
EnsemblFAM129B - 9q34.11 [CytoView hg19]  FAM129B - 9q34.11 [CytoView hg38]
Mapping of homologs : NCBIFAM129B [Mapview hg19]  FAM129B [Mapview hg38]
OMIM614045   
Gene and transcription
Genbank (Entrez)AB210016 AF151783 AF192911 AK023580 AK025804
RefSeq transcript (Entrez)NM_001035534 NM_022833
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAM129B
Cluster EST : UnigeneHs.522401 [ NCBI ]
CGAP (NCI)Hs.522401
Alternative Splicing GalleryENSG00000136830
Gene ExpressionFAM129B [ NCBI-GEO ]   FAM129B [ EBI - ARRAY_EXPRESS ]   FAM129B [ SEEK ]   FAM129B [ MEM ]
Gene Expression Viewer (FireBrowse)FAM129B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64855
GTEX Portal (Tissue expression)FAM129B
Human Protein AtlasENSG00000136830-FAM129B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96TA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96TA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96TA1
Splice isoforms : SwissVarQ96TA1
PhosPhoSitePlusQ96TA1
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Niban-like    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)FAM129B
DMDM Disease mutations64855
Blocks (Seattle)FAM129B
SuperfamilyQ96TA1
Human Protein Atlas [tissue]ENSG00000136830-FAM129B [tissue]
Peptide AtlasQ96TA1
HPRD10804
IPIIPI00647286   IPI00456750   IPI01015096   IPI00917117   
Protein Interaction databases
DIP (DOE-UCLA)Q96TA1
IntAct (EBI)Q96TA1
FunCoupENSG00000136830
BioGRIDFAM129B
STRING (EMBL)FAM129B
ZODIACFAM129B
Ontologies - Pathways
QuickGOQ96TA1
Ontology : AmiGOtranscription coactivator activity  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  adherens junction  axon guidance  negative regulation of cell proliferation  negative regulation of angiogenesis  cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  gonadotropin secretion  gonadotropin secretion  RNA folding  positive regulation of embryonic development  negative regulation of apoptotic process  hypomethylation of CpG island  cadherin binding  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of skeletal muscle fiber development  extracellular exosome  negative regulation of DNA biosynthetic process  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBItranscription coactivator activity  nucleus  nucleus  nucleoplasm  cytoplasm  cytosol  plasma membrane  adherens junction  axon guidance  negative regulation of cell proliferation  negative regulation of angiogenesis  cell differentiation  negative regulation of vascular endothelial growth factor receptor signaling pathway  gonadotropin secretion  gonadotropin secretion  RNA folding  positive regulation of embryonic development  negative regulation of apoptotic process  hypomethylation of CpG island  cadherin binding  negative regulation of Notch signaling pathway  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of skeletal muscle fiber development  extracellular exosome  negative regulation of DNA biosynthetic process  positive regulation of transcription regulatory region DNA binding  
NDEx NetworkFAM129B
Atlas of Cancer Signalling NetworkFAM129B
Wikipedia pathwaysFAM129B
Orthology - Evolution
OrthoDB64855
GeneTree (enSembl)ENSG00000136830
Phylogenetic Trees/Animal Genes : TreeFamFAM129B
HOVERGENQ96TA1
HOGENOMQ96TA1
Homologs : HomoloGeneFAM129B
Homology/Alignments : Family Browser (UCSC)FAM129B
Gene fusions - Rearrangements
Fusion : MitelmanCNN1/FAM129B [19p13.2/9q33.3]  [t(9;19)(q34;p13)]  
Fusion : MitelmanFAM129B/CLDN4 [9q33.3/7q11.23]  [t(7;9)(q11;q34)]  
Fusion : MitelmanFAM129B/OLFM1 [9q33.3/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : MitelmanFAM129B/PYROXD1 [9q33.3/12p12.1]  [t(9;12)(q34;p12)]  
Fusion : MitelmanFAM129B/SEC16A [9q33.3/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : MitelmanZNF79/FAM129B [9q33.3/9q33.3]  [t(9;9)(q33;q34)]  
Fusion PortalC11orf75 FAM129B 9q33.3 PRAD
Fusion PortalCNN1 19p13.2 FAM129B 9q33.3 PRAD
Fusion PortalFAM129B 9q33.3 CLDN4 7q11.23 PRAD
Fusion PortalFAM129B 9q33.3 OLFM1 9q34.3 BRCA
Fusion PortalFAM129B 9q33.3 PYROXD1 12p12.1 BRCA
Fusion PortalFAM129B 9q33.3 SEC16A 9q34.3 BRCA
Fusion PortalZNF79 9q33.3 FAM129B 9q33.3 BRCA
Fusion : QuiverFAM129B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAM129B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAM129B
dbVarFAM129B
ClinVarFAM129B
1000_GenomesFAM129B 
Exome Variant ServerFAM129B
ExAC (Exome Aggregation Consortium)ENSG00000136830
GNOMAD BrowserENSG00000136830
Genetic variants : HAPMAP64855
Genomic Variants (DGV)FAM129B [DGVbeta]
DECIPHERFAM129B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAM129B 
Mutations
ICGC Data PortalFAM129B 
TCGA Data PortalFAM129B 
Broad Tumor PortalFAM129B
OASIS PortalFAM129B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAM129B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAM129B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAM129B
DgiDB (Drug Gene Interaction Database)FAM129B
DoCM (Curated mutations)FAM129B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAM129B (select a term)
intoGenFAM129B
Cancer3DFAM129B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614045   
Orphanet
DisGeNETFAM129B
MedgenFAM129B
Genetic Testing Registry FAM129B
NextProtQ96TA1 [Medical]
TSGene64855
GENETestsFAM129B
Target ValidationFAM129B
Huge Navigator FAM129B [HugePedia]
snp3D : Map Gene to Disease64855
BioCentury BCIQFAM129B
ClinGenFAM129B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64855
Chemical/Pharm GKB GenePA162385984
Clinical trialFAM129B
Miscellaneous
canSAR (ICR)FAM129B (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAM129B
EVEXFAM129B
GoPubMedFAM129B
iHOPFAM129B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:25:00 CEST 2018
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