Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FAM20C (FAM20C golgi associated secretory pathway kinase)

Identity

Alias_namesfamily with sequence similarity 20, member C
Alias_symbol (synonym)IMAGE:4942737
DKFZp547D065
DMP4
G-CK
Other aliasDMP-4
GEF-CK
RNS
HGNC (Hugo) FAM20C
LocusID (NCBI) 56975
Atlas_Id 63130
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 192969 and ends at 260774 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM20C (7p22.3) / PRKAR1B (7p22.3)FAM20C (7p22.3) / RAPGEF1 (9q34.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FAM20C   22140
Cards
Entrez_Gene (NCBI)FAM20C  56975  FAM20C golgi associated secretory pathway kinase
AliasesDMP-4; DMP4; G-CK; GEF-CK; 
RNS
GeneCards (Weizmann)FAM20C
Ensembl hg19 (Hinxton)ENSG00000177706 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177706 [Gene_View]  ENSG00000177706 [Sequence]  chr7:192969-260774 [Contig_View]  FAM20C [Vega]
ICGC DataPortalENSG00000177706
TCGA cBioPortalFAM20C
AceView (NCBI)FAM20C
Genatlas (Paris)FAM20C
WikiGenes56975
SOURCE (Princeton)FAM20C
Genetics Home Reference (NIH)FAM20C
Genomic and cartography
GoldenPath hg38 (UCSC)FAM20C  -     chr7:192969-260774 +  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAM20C  -     7p22.3   [Description]    (hg19-Feb_2009)
GoldenPathFAM20C - 7p22.3 [CytoView hg19]  FAM20C - 7p22.3 [CytoView hg38]
ImmunoBaseENSG00000177706
Mapping of homologs : NCBIFAM20C [Mapview hg19]  FAM20C [Mapview hg38]
OMIM259775   611061   
Gene and transcription
Genbank (Entrez)AA135568 AB545605 AF533706 AK026140 AK054704
RefSeq transcript (Entrez)NM_020223
RefSeq genomic (Entrez)NC_000007 NG_033970 NT_187558 NT_187653 NW_021159998
Consensus coding sequences : CCDS (NCBI)FAM20C
Cluster EST : UnigeneHs.733582 [ NCBI ]
CGAP (NCI)Hs.733582
Alternative Splicing GalleryENSG00000177706
Gene ExpressionFAM20C [ NCBI-GEO ]   FAM20C [ EBI - ARRAY_EXPRESS ]   FAM20C [ SEEK ]   FAM20C [ MEM ]
Gene Expression Viewer (FireBrowse)FAM20C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56975
GTEX Portal (Tissue expression)FAM20C
Human Protein AtlasENSG00000177706-FAM20C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IXL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IXL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IXL6
Splice isoforms : SwissVarQ8IXL6
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IXL6
Domains : Interpro (EBI)FAM20    FAM20_C   
Domain families : Pfam (Sanger)Fam20C (PF06702)   
Domain families : Pfam (NCBI)pfam06702   
Conserved Domain (NCBI)FAM20C
DMDM Disease mutations56975
Blocks (Seattle)FAM20C
SuperfamilyQ8IXL6
Human Protein Atlas [tissue]ENSG00000177706-FAM20C [tissue]
Peptide AtlasQ8IXL6
HPRD13298
IPIIPI00470607   IPI01008847   
Protein Interaction databases
DIP (DOE-UCLA)Q8IXL6
IntAct (EBI)Q8IXL6
FunCoupENSG00000177706
BioGRIDFAM20C
STRING (EMBL)FAM20C
ZODIACFAM20C
Ontologies - Pathways
QuickGOQ8IXL6
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calcium ion binding  protein binding  ATP binding  extracellular space  endoplasmic reticulum lumen  Golgi apparatus  Golgi apparatus  protein phosphorylation  protein phosphorylation  phosphotransferase activity, alcohol group as acceptor  manganese ion binding  positive regulation of bone mineralization  biomineral tissue development  osteoclast maturation  regulation of fibroblast growth factor receptor signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of osteoblast differentiation  ATP metabolic process  regulation of phosphorus metabolic process  extracellular exosome  enamel mineralization  odontoblast differentiation  dentinogenesis  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  calcium ion binding  protein binding  ATP binding  extracellular space  endoplasmic reticulum lumen  Golgi apparatus  Golgi apparatus  protein phosphorylation  protein phosphorylation  phosphotransferase activity, alcohol group as acceptor  manganese ion binding  positive regulation of bone mineralization  biomineral tissue development  osteoclast maturation  regulation of fibroblast growth factor receptor signaling pathway  post-translational protein modification  cellular protein metabolic process  positive regulation of osteoblast differentiation  ATP metabolic process  regulation of phosphorus metabolic process  extracellular exosome  enamel mineralization  odontoblast differentiation  dentinogenesis  
NDEx NetworkFAM20C
Atlas of Cancer Signalling NetworkFAM20C
Wikipedia pathwaysFAM20C
Orthology - Evolution
OrthoDB56975
GeneTree (enSembl)ENSG00000177706
Phylogenetic Trees/Animal Genes : TreeFamFAM20C
HOGENOMQ8IXL6
Homologs : HomoloGeneFAM20C
Homology/Alignments : Family Browser (UCSC)FAM20C
Gene fusions - Rearrangements
Fusion : QuiverFAM20C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAM20C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAM20C
dbVarFAM20C
ClinVarFAM20C
1000_GenomesFAM20C 
Exome Variant ServerFAM20C
ExAC (Exome Aggregation Consortium)ENSG00000177706
GNOMAD BrowserENSG00000177706
Varsome BrowserFAM20C
Genetic variants : HAPMAP56975
Genomic Variants (DGV)FAM20C [DGVbeta]
DECIPHERFAM20C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAM20C 
Mutations
ICGC Data PortalFAM20C 
TCGA Data PortalFAM20C 
Broad Tumor PortalFAM20C
OASIS PortalFAM20C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAM20C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFAM20C
Mutations and Diseases : HGMDFAM20C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAM20C
DgiDB (Drug Gene Interaction Database)FAM20C
DoCM (Curated mutations)FAM20C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAM20C (select a term)
intoGenFAM20C
Cancer3DFAM20C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM259775    611061   
Orphanet2713   
DisGeNETFAM20C
MedgenFAM20C
Genetic Testing Registry FAM20C
NextProtQ8IXL6 [Medical]
TSGene56975
GENETestsFAM20C
Target ValidationFAM20C
Huge Navigator FAM20C [HugePedia]
snp3D : Map Gene to Disease56975
BioCentury BCIQFAM20C
ClinGenFAM20C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56975
Chemical/Pharm GKB GenePA134898453
Clinical trialFAM20C
Miscellaneous
canSAR (ICR)FAM20C (select the gene name)
DataMed IndexFAM20C
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAM20C
EVEXFAM20C
GoPubMedFAM20C
iHOPFAM20C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Sep 3 15:27:45 CEST 2019
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