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FAM3B (FAM3 metabolism regulating signaling molecule B)

Identity

Alias (NCBI)2-21
C21orf11
C21orf76
ORF9
PANDER
PRED44
HGNC (Hugo) FAM3B
HGNC Alias symbD21M16SJHU19e
PRED44
2-21
ORF9
C21orf76
PANDER
HGNC Alias namepancreatic-derived factor
HGNC Previous nameC21orf11
HGNC Previous namechromosome 21 open reading frame 11
 family with sequence similarity 3 member B
LocusID (NCBI) 54097
Atlas_Id 53174
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 41316801 and ends at 41357727 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GLI3 (7p14.1) / FAM3B (21q22.3)MORC3 (21q22.12) / FAM3B (21q22.3)MORC3 21q22.12 / FAM3B 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FAM3B   1253
Cards
Entrez_Gene (NCBI)FAM3B    FAM3 metabolism regulating signaling molecule B
Aliases2-21; C21orf11; C21orf76; ORF9; 
PANDER; PRED44
GeneCards (Weizmann)FAM3B
Ensembl hg19 (Hinxton)ENSG00000183844 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183844 [Gene_View]  ENSG00000183844 [Sequence]  chr21:41316801-41357727 [Contig_View]  FAM3B [Vega]
ICGC DataPortalENSG00000183844
TCGA cBioPortalFAM3B
AceView (NCBI)FAM3B
Genatlas (Paris)FAM3B
SOURCE (Princeton)FAM3B
Genetics Home Reference (NIH)FAM3B
Genomic and cartography
GoldenPath hg38 (UCSC)FAM3B  -     chr21:41316801-41357727 +  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAM3B  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathFAM3B - 21q22.3 [CytoView hg19]  FAM3B - 21q22.3 [CytoView hg38]
ImmunoBaseENSG00000183844
Genome Data Viewer NCBIFAM3B [Mapview hg19]  
OMIM608617   
Gene and transcription
Genbank (Entrez)AF375989 AF494379 AJ409094 AK125528 AK302095
RefSeq transcript (Entrez)NM_058186 NM_206964
Consensus coding sequences : CCDS (NCBI)FAM3B
Gene ExpressionFAM3B [ NCBI-GEO ]   FAM3B [ EBI - ARRAY_EXPRESS ]   FAM3B [ SEEK ]   FAM3B [ MEM ]
Gene Expression Viewer (FireBrowse)FAM3B [ Firebrowse - Broad ]
GenevisibleExpression of FAM3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54097
GTEX Portal (Tissue expression)FAM3B
Human Protein AtlasENSG00000183844-FAM3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP58499   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP58499  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP58499
PhosPhoSitePlusP58499
Domains : Interpro (EBI)FAM3    FAM3B    ILEI/PANDER_dom   
Domain families : Pfam (Sanger)ILEI (PF15711)   
Domain families : Pfam (NCBI)pfam15711   
Conserved Domain (NCBI)FAM3B
SuperfamilyP58499
AlphaFold pdb e-kbP58499   
Human Protein Atlas [tissue]ENSG00000183844-FAM3B [tissue]
HPRD10552
Protein Interaction databases
DIP (DOE-UCLA)P58499
IntAct (EBI)P58499
BioGRIDFAM3B
STRING (EMBL)FAM3B
ZODIACFAM3B
Ontologies - Pathways
QuickGOP58499
Ontology : AmiGOcytokine activity  protein binding  extracellular region  extracellular space  apoptotic process  signal transduction  insulin secretion  insulin secretion  glucose homeostasis  extracellular exosome  
Ontology : EGO-EBIcytokine activity  protein binding  extracellular region  extracellular space  apoptotic process  signal transduction  insulin secretion  insulin secretion  glucose homeostasis  extracellular exosome  
NDEx NetworkFAM3B
Atlas of Cancer Signalling NetworkFAM3B
Wikipedia pathwaysFAM3B
Orthology - Evolution
OrthoDB54097
GeneTree (enSembl)ENSG00000183844
Phylogenetic Trees/Animal Genes : TreeFamFAM3B
Homologs : HomoloGeneFAM3B
Homology/Alignments : Family Browser (UCSC)FAM3B
Gene fusions - Rearrangements
Fusion : MitelmanGLI3/FAM3B [7p14.1/21q22.3]  
Fusion : MitelmanMORC3/FAM3B [21q22.12/21q22.3]  
Fusion : QuiverFAM3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAM3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAM3B
dbVarFAM3B
ClinVarFAM3B
MonarchFAM3B
1000_GenomesFAM3B 
Exome Variant ServerFAM3B
GNOMAD BrowserENSG00000183844
Varsome BrowserFAM3B
ACMGFAM3B variants
VarityP58499
Genomic Variants (DGV)FAM3B [DGVbeta]
DECIPHERFAM3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAM3B 
Mutations
ICGC Data PortalFAM3B 
TCGA Data PortalFAM3B 
Broad Tumor PortalFAM3B
OASIS PortalFAM3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAM3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFAM3B
Mutations and Diseases : HGMDFAM3B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFAM3B
DgiDB (Drug Gene Interaction Database)FAM3B
DoCM (Curated mutations)FAM3B
CIViC (Clinical Interpretations of Variants in Cancer)FAM3B
Cancer3DFAM3B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608617   
Orphanet
DisGeNETFAM3B
MedgenFAM3B
Genetic Testing Registry FAM3B
NextProtP58499 [Medical]
GENETestsFAM3B
Target ValidationFAM3B
Huge Navigator FAM3B [HugePedia]
ClinGenFAM3B
Clinical trials, drugs, therapy
MyCancerGenomeFAM3B
Protein Interactions : CTDFAM3B
Pharm GKB GenePA27979
PharosP58499
Clinical trialFAM3B
Miscellaneous
canSAR (ICR)FAM3B
HarmonizomeFAM3B
DataMed IndexFAM3B
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFAM3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:08:54 CEST 2021

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