FAM3C (FAM3 metabolism regulating signaling molecule C)

2007-10-01  

Identity

HGNC
LOCATION
7q31.31
LOCUSID
ALIAS
GS3786,ILEI
FUSION GENES

Other Information

Locus ID:

NCBI: 10447
MIM: 608618
HGNC: 18664
Ensembl: ENSG00000196937

Variants:

dbSNP: 10447
ClinVar: 10447
TCGA: ENSG00000196937
COSMIC: FAM3C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196937ENST00000359943Q92520
ENSG00000196937ENST00000412653C9JMN4
ENSG00000196937ENST00000426156C9JP35

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193961692009A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.350
169596142006ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells.74
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
121607272002Cloning, expression, and initial characterization of a novel cytokine-like gene family.48
240724922014ILEI drives epithelial to mesenchymal transition and metastatic progression in the lung cancer cell line A549.14
247386652014ILEI: a novel marker for epithelial-mesenchymal transition and poor prognosis in colorectal cancer.13
191099322009Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy.11
252129662014Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen-urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression.9
221598212012A follow-up association study of two genetic variants for bone mineral density variation in Caucasians.8
306926352019TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis.8

Citation

Dessen P

FAM3C (FAM3 metabolism regulating signaling molecule C)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49752/fam3c