Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FANCM (Fanconi anemia complementation group M)

Identity

Alias_namesKIAA1596
KIAA1596
Alias_symbol (synonym)FAAP250
Other alias
HGNC (Hugo) FANCM
LocusID (NCBI) 57697
Atlas_Id 43053
Location 14q21.2  [Link to chromosome band 14q21]
Location_base_pair Starts at 45135939 and ends at 45200890 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 2 ]
  Fanconi anemia Familial Myeloproliferative Disorders


External links

Nomenclature
HGNC (Hugo)FANCM   23168
LRG (Locus Reference Genomic)LRG_502
Cards
Entrez_Gene (NCBI)FANCM  57697  Fanconi anemia complementation group M
AliasesFAAP250; KIAA1596
GeneCards (Weizmann)FANCM
Ensembl hg19 (Hinxton)ENSG00000187790 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000187790 [Gene_View]  chr14:45135939-45200890 [Contig_View]  FANCM [Vega]
ICGC DataPortalENSG00000187790
TCGA cBioPortalFANCM
AceView (NCBI)FANCM
Genatlas (Paris)FANCM
WikiGenes57697
SOURCE (Princeton)FANCM
Genetics Home Reference (NIH)FANCM
Genomic and cartography
GoldenPath hg38 (UCSC)FANCM  -     chr14:45135939-45200890 +  14q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FANCM  -     14q21.2   [Description]    (hg19-Feb_2009)
EnsemblFANCM - 14q21.2 [CytoView hg19]  FANCM - 14q21.2 [CytoView hg38]
Mapping of homologs : NCBIFANCM [Mapview hg19]  FANCM [Mapview hg38]
OMIM189960   609644   614087   
Gene and transcription
Genbank (Entrez)AB046816 AK001672 AK093422 AL833656 BC036056
RefSeq transcript (Entrez)NM_001308133 NM_001308134 NM_020937
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FANCM
Cluster EST : UnigeneHs.509229 [ NCBI ]
CGAP (NCI)Hs.509229
Alternative Splicing GalleryENSG00000187790
Gene ExpressionFANCM [ NCBI-GEO ]   FANCM [ EBI - ARRAY_EXPRESS ]   FANCM [ SEEK ]   FANCM [ MEM ]
Gene Expression Viewer (FireBrowse)FANCM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57697
GTEX Portal (Tissue expression)FANCM
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYD8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYD8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYD8
Splice isoforms : SwissVarQ8IYD8
PhosPhoSitePlusQ8IYD8
Domaine pattern : Prosite (Expaxy)HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DNA_repair_nuc_XPF/helicase    ERCC4_domain    FANCM-MHF-bd    Helicase/UvrB_N    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    Restrct_endonuc-II-like    RuvA_2-like   
Domain families : Pfam (Sanger)ERCC4 (PF02732)    FANCM-MHF_bd (PF16783)    Helicase_C (PF00271)    ResIII (PF04851)   
Domain families : Pfam (NCBI)pfam02732    pfam16783    pfam00271    pfam04851   
Domain families : Smart (EMBL)DEXDc (SM00487)  ERCC4 (SM00891)  HELICc (SM00490)  
Conserved Domain (NCBI)FANCM
DMDM Disease mutations57697
Blocks (Seattle)FANCM
PDB (SRS)4BXO    4DAY    4DRB    4E45    4M6W   
PDB (PDBSum)4BXO    4DAY    4DRB    4E45    4M6W   
PDB (IMB)4BXO    4DAY    4DRB    4E45    4M6W   
PDB (RSDB)4BXO    4DAY    4DRB    4E45    4M6W   
Structural Biology KnowledgeBase4BXO    4DAY    4DRB    4E45    4M6W   
SCOP (Structural Classification of Proteins)4BXO    4DAY    4DRB    4E45    4M6W   
CATH (Classification of proteins structures)4BXO    4DAY    4DRB    4E45    4M6W   
SuperfamilyQ8IYD8
Human Protein AtlasENSG00000187790
Peptide AtlasQ8IYD8
HPRD13876
IPIIPI00176581   IPI00217755   IPI01014004   IPI01026535   IPI01026202   IPI01026338   IPI01024981   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYD8
IntAct (EBI)Q8IYD8
FunCoupENSG00000187790
BioGRIDFANCM
STRING (EMBL)FANCM
ZODIACFANCM
Ontologies - Pathways
QuickGOQ8IYD8
Ontology : AmiGOresolution of meiotic recombination intermediates  DNA binding  chromatin binding  helicase activity  nuclease activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  replication fork processing  interstrand cross-link repair  Fanconi anaemia nuclear complex  FANCM-MHF complex  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIresolution of meiotic recombination intermediates  DNA binding  chromatin binding  helicase activity  nuclease activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  replication fork processing  interstrand cross-link repair  Fanconi anaemia nuclear complex  FANCM-MHF complex  nucleic acid phosphodiester bond hydrolysis  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkFANCM
Atlas of Cancer Signalling NetworkFANCM
Wikipedia pathwaysFANCM
Orthology - Evolution
OrthoDB57697
GeneTree (enSembl)ENSG00000187790
Phylogenetic Trees/Animal Genes : TreeFamFANCM
HOVERGENQ8IYD8
HOGENOMQ8IYD8
Homologs : HomoloGeneFANCM
Homology/Alignments : Family Browser (UCSC)FANCM
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFANCM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FANCM
dbVarFANCM
ClinVarFANCM
1000_GenomesFANCM 
Exome Variant ServerFANCM
ExAC (Exome Aggregation Consortium)FANCM (select the gene name)
Genetic variants : HAPMAP57697
Genomic Variants (DGV)FANCM [DGVbeta]
DECIPHERFANCM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFANCM 
Mutations
ICGC Data PortalFANCM 
TCGA Data PortalFANCM 
Broad Tumor PortalFANCM
OASIS PortalFANCM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFANCM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFANCM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)Fanconi anemia database
BioMutasearch FANCM
DgiDB (Drug Gene Interaction Database)FANCM
DoCM (Curated mutations)FANCM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FANCM (select a term)
intoGenFANCM
Cancer3DFANCM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189960    609644    614087   
Orphanet634   
MedgenFANCM
Genetic Testing Registry FANCM
NextProtQ8IYD8 [Medical]
TSGene57697
GENETestsFANCM
Target ValidationFANCM
Huge Navigator FANCM [HugePedia]
snp3D : Map Gene to Disease57697
BioCentury BCIQFANCM
ClinGenFANCM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57697
Chemical/Pharm GKB GenePA134943156
Clinical trialFANCM
Miscellaneous
canSAR (ICR)FANCM (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFANCM
EVEXFANCM
GoPubMedFANCM
iHOPFANCM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:00:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.