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FAP (fibroblast activation protein alpha)

Identity

Alias_namesfibroblast activation protein
Alias_symbol (synonym)DPPIV
Other aliasFAPA
FAPalpha
SIMP
HGNC (Hugo) FAP
LocusID (NCBI) 2191
Atlas_Id 40530
Location 2q24.2  [Link to chromosome band 2q24]
Location_base_pair Starts at 162170684 and ends at 162243557 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKNAD1 (1p13.3) / FAP (2q24.2)BAZ2B (2q24.2) / FAP (2q24.2)FAP (2q24.2) / IFIH1 (2q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FAP   3590
Cards
Entrez_Gene (NCBI)FAP  2191  fibroblast activation protein alpha
AliasesDPPIV; FAPA; FAPalpha; SIMP
GeneCards (Weizmann)FAP
Ensembl hg19 (Hinxton)ENSG00000078098 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078098 [Gene_View]  chr2:162170684-162243557 [Contig_View]  FAP [Vega]
ICGC DataPortalENSG00000078098
TCGA cBioPortalFAP
AceView (NCBI)FAP
Genatlas (Paris)FAP
WikiGenes2191
SOURCE (Princeton)FAP
Genetics Home Reference (NIH)FAP
Genomic and cartography
GoldenPath hg38 (UCSC)FAP  -     chr2:162170684-162243557 -  2q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAP  -     2q24.2   [Description]    (hg19-Feb_2009)
EnsemblFAP - 2q24.2 [CytoView hg19]  FAP - 2q24.2 [CytoView hg38]
Mapping of homologs : NCBIFAP [Mapview hg19]  FAP [Mapview hg38]
OMIM600403   
Gene and transcription
Genbank (Entrez)AK055327 AK297118 AK309260 AK310293 AK315448
RefSeq transcript (Entrez)NM_001291807 NM_004460
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAP
Cluster EST : UnigeneHs.654370 [ NCBI ]
CGAP (NCI)Hs.654370
Alternative Splicing GalleryENSG00000078098
Gene ExpressionFAP [ NCBI-GEO ]   FAP [ EBI - ARRAY_EXPRESS ]   FAP [ SEEK ]   FAP [ MEM ]
Gene Expression Viewer (FireBrowse)FAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2191
GTEX Portal (Tissue expression)FAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12884   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12884  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12884
Splice isoforms : SwissVarQ12884
PhosPhoSitePlusQ12884
Domains : Interpro (EBI)AB_hydrolase    FAP/Dpf2    Pept_S9_AS    Peptidase_S9    Peptidase_S9B_N   
Domain families : Pfam (Sanger)DPPIV_N (PF00930)    Peptidase_S9 (PF00326)   
Domain families : Pfam (NCBI)pfam00930    pfam00326   
Conserved Domain (NCBI)FAP
DMDM Disease mutations2191
Blocks (Seattle)FAP
PDB (SRS)1Z68   
PDB (PDBSum)1Z68   
PDB (IMB)1Z68   
PDB (RSDB)1Z68   
Structural Biology KnowledgeBase1Z68   
SCOP (Structural Classification of Proteins)1Z68   
CATH (Classification of proteins structures)1Z68   
SuperfamilyQ12884
Human Protein AtlasENSG00000078098
Peptide AtlasQ12884
HPRD02674
IPIIPI00295461   IPI00925672   IPI00925419   IPI00926234   IPI00375396   IPI01014547   
Protein Interaction databases
DIP (DOE-UCLA)Q12884
IntAct (EBI)Q12884
FunCoupENSG00000078098
BioGRIDFAP
STRING (EMBL)FAP
ZODIACFAP
Ontologies - Pathways
QuickGOQ12884
Ontology : AmiGOangiogenesis  protease binding  endopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  integrin binding  protein binding  extracellular space  cytoplasm  plasma membrane  plasma membrane  focal adhesion  proteolysis  cell adhesion  peptidase activity  serine-type peptidase activity  serine-type peptidase activity  serine-type peptidase activity  dipeptidyl-peptidase activity  dipeptidyl-peptidase activity  cell surface  regulation of collagen catabolic process  negative regulation of extracellular matrix disassembly  integral component of membrane  lamellipodium  lamellipodium membrane  ruffle membrane  protein homodimerization activity  protein homodimerization activity  endothelial cell migration  apical part of cell  basal part of cell  protein dimerization activity  proteolysis involved in cellular protein catabolic process  regulation of fibrinolysis  negative regulation of cell proliferation involved in contact inhibition  positive regulation of cell cycle arrest  invadopodium membrane  mitotic cell cycle arrest  melanocyte proliferation  positive regulation of execution phase of apoptosis  melanocyte apoptotic process  negative regulation of extracellular matrix organization  
Ontology : EGO-EBIangiogenesis  protease binding  endopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  integrin binding  protein binding  extracellular space  cytoplasm  plasma membrane  plasma membrane  focal adhesion  proteolysis  cell adhesion  peptidase activity  serine-type peptidase activity  serine-type peptidase activity  serine-type peptidase activity  dipeptidyl-peptidase activity  dipeptidyl-peptidase activity  cell surface  regulation of collagen catabolic process  negative regulation of extracellular matrix disassembly  integral component of membrane  lamellipodium  lamellipodium membrane  ruffle membrane  protein homodimerization activity  protein homodimerization activity  endothelial cell migration  apical part of cell  basal part of cell  protein dimerization activity  proteolysis involved in cellular protein catabolic process  regulation of fibrinolysis  negative regulation of cell proliferation involved in contact inhibition  positive regulation of cell cycle arrest  invadopodium membrane  mitotic cell cycle arrest  melanocyte proliferation  positive regulation of execution phase of apoptosis  melanocyte apoptotic process  negative regulation of extracellular matrix organization  
NDEx NetworkFAP
Atlas of Cancer Signalling NetworkFAP
Wikipedia pathwaysFAP
Orthology - Evolution
OrthoDB2191
GeneTree (enSembl)ENSG00000078098
Phylogenetic Trees/Animal Genes : TreeFamFAP
HOVERGENQ12884
HOGENOMQ12884
Homologs : HomoloGeneFAP
Homology/Alignments : Family Browser (UCSC)FAP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAP
dbVarFAP
ClinVarFAP
1000_GenomesFAP 
Exome Variant ServerFAP
ExAC (Exome Aggregation Consortium)FAP (select the gene name)
Genetic variants : HAPMAP2191
Genomic Variants (DGV)FAP [DGVbeta]
DECIPHERFAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAP 
Mutations
ICGC Data PortalFAP 
TCGA Data PortalFAP 
Broad Tumor PortalFAP
OASIS PortalFAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAP
DgiDB (Drug Gene Interaction Database)FAP
DoCM (Curated mutations)FAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAP (select a term)
intoGenFAP
Cancer3DFAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600403   
Orphanet
MedgenFAP
Genetic Testing Registry FAP
NextProtQ12884 [Medical]
TSGene2191
GENETestsFAP
Target ValidationFAP
Huge Navigator FAP [HugePedia]
snp3D : Map Gene to Disease2191
BioCentury BCIQFAP
ClinGenFAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2191
Chemical/Pharm GKB GenePA28003
Clinical trialFAP
Miscellaneous
canSAR (ICR)FAP (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAP
EVEXFAP
GoPubMedFAP
iHOPFAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:57 CEST 2017

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