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FARP2 (FERM, ARH/RhoGEF and pleckstrin domain protein 2)

Identity

Alias_namesFERM, RhoGEF and pleckstrin domain protein 2
Alias_symbol (synonym)KIAA0793
FIR
PLEKHC3
FRG
Other alias
HGNC (Hugo) FARP2
LocusID (NCBI) 9855
Atlas_Id 63298
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 241356249 and ends at 241466036 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FARP2 (2q37.3) / GTDC1 (2q22.3)FARP2 (2q37.3) / SEPT2 (2q37.3)FARP2 (2q37.3) / SMARCC1 (3p21.31)
FARP2 (2q37.3) / THAP4 (2q37.3)HSPB1 (7q11.23) / FARP2 (2q37.3)ITGAV (2q32.1) / FARP2 (2q37.3)
SNED1 (2q37.3) / FARP2 (2q37.3)TP53 (17p13.1) / FARP2 (2q37.3)ITGAV FARP2
TP53 FARP2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FARP2   16460
Cards
Entrez_Gene (NCBI)FARP2  9855  FERM, ARH/RhoGEF and pleckstrin domain protein 2
AliasesFIR; FRG; PLEKHC3
GeneCards (Weizmann)FARP2
Ensembl hg19 (Hinxton)ENSG00000006607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006607 [Gene_View]  chr2:241356249-241466036 [Contig_View]  FARP2 [Vega]
ICGC DataPortalENSG00000006607
TCGA cBioPortalFARP2
AceView (NCBI)FARP2
Genatlas (Paris)FARP2
WikiGenes9855
SOURCE (Princeton)FARP2
Genetics Home Reference (NIH)FARP2
Genomic and cartography
GoldenPath hg38 (UCSC)FARP2  -     chr2:241356249-241466036 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FARP2  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblFARP2 - 2q37.3 [CytoView hg19]  FARP2 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIFARP2 [Mapview hg19]  FARP2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB018336 AK127510 AK300435 AL122052 AW014580
RefSeq transcript (Entrez)NM_001282983 NM_001282984 NM_014808
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FARP2
Cluster EST : UnigeneHs.726316 [ NCBI ]
CGAP (NCI)Hs.726316
Alternative Splicing GalleryENSG00000006607
Gene ExpressionFARP2 [ NCBI-GEO ]   FARP2 [ EBI - ARRAY_EXPRESS ]   FARP2 [ SEEK ]   FARP2 [ MEM ]
Gene Expression Viewer (FireBrowse)FARP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9855
GTEX Portal (Tissue expression)FARP2
Human Protein AtlasENSG00000006607-FARP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94887   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94887  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94887
Splice isoforms : SwissVarO94887
PhosPhoSitePlusO94887
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    FERM_1 (PS00660)    FERM_3 (PS50057)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)Band_41_domain    DH-domain    Ez/rad/moesin-like    FERM-adjacent    FERM/acyl-CoA-bd_prot_3-hlx    FERM_central    FERM_CS    FERM_domain    FERM_N    FERM_PH-like_C    PH_dom-like    PH_domain    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)FA (PF08736)    FERM_C (PF09380)    FERM_M (PF00373)    FERM_N (PF09379)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam08736    pfam09380    pfam00373    pfam09379    pfam00169    pfam00621   
Domain families : Smart (EMBL)B41 (SM00295)  FA (SM01195)  FERM_C (SM01196)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)FARP2
DMDM Disease mutations9855
Blocks (Seattle)FARP2
SuperfamilyO94887
Human Protein Atlas [tissue]ENSG00000006607-FARP2 [tissue]
Peptide AtlasO94887
HPRD16885
IPIIPI00744221   IPI00171819   IPI00893939   IPI00983027   IPI00893529   IPI00893661   IPI00893378   IPI00893276   IPI00893410   
Protein Interaction databases
DIP (DOE-UCLA)O94887
IntAct (EBI)O94887
FunCoupENSG00000006607
BioGRIDFARP2
STRING (EMBL)FARP2
ZODIACFARP2
Ontologies - Pathways
QuickGOO94887
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  cytoplasm  cytosol  cytoskeleton  cell adhesion  cytoskeletal protein binding  neuron remodeling  Rac protein signal transduction  extrinsic component of membrane  hair cycle process  osteoclast differentiation  Rac guanyl-nucleotide exchange factor activity  actin cytoskeleton reorganization  regulation of integrin activation  regulation of Rho protein signal transduction  positive regulation of GTPase activity  semaphorin-plexin signaling pathway  podosome assembly  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  cytoplasm  cytosol  cytoskeleton  cell adhesion  cytoskeletal protein binding  neuron remodeling  Rac protein signal transduction  extrinsic component of membrane  hair cycle process  osteoclast differentiation  Rac guanyl-nucleotide exchange factor activity  actin cytoskeleton reorganization  regulation of integrin activation  regulation of Rho protein signal transduction  positive regulation of GTPase activity  semaphorin-plexin signaling pathway  podosome assembly  
Pathways : KEGGRap1 signaling pathway    Adherens junction   
NDEx NetworkFARP2
Atlas of Cancer Signalling NetworkFARP2
Wikipedia pathwaysFARP2
Orthology - Evolution
OrthoDB9855
GeneTree (enSembl)ENSG00000006607
Phylogenetic Trees/Animal Genes : TreeFamFARP2
HOVERGENO94887
HOGENOMO94887
Homologs : HomoloGeneFARP2
Homology/Alignments : Family Browser (UCSC)FARP2
Gene fusions - Rearrangements
Fusion: TCGAITGAV FARP2
Fusion: TCGATP53 FARP2
Fusion: Tumor Portal FARP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFARP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FARP2
dbVarFARP2
ClinVarFARP2
1000_GenomesFARP2 
Exome Variant ServerFARP2
ExAC (Exome Aggregation Consortium)ENSG00000006607
GNOMAD BrowserENSG00000006607
Genetic variants : HAPMAP9855
Genomic Variants (DGV)FARP2 [DGVbeta]
DECIPHERFARP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFARP2 
Mutations
ICGC Data PortalFARP2 
TCGA Data PortalFARP2 
Broad Tumor PortalFARP2
OASIS PortalFARP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFARP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFARP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FARP2
DgiDB (Drug Gene Interaction Database)FARP2
DoCM (Curated mutations)FARP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FARP2 (select a term)
intoGenFARP2
Cancer3DFARP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenFARP2
Genetic Testing Registry FARP2
NextProtO94887 [Medical]
TSGene9855
GENETestsFARP2
Target ValidationFARP2
Huge Navigator FARP2 [HugePedia]
snp3D : Map Gene to Disease9855
BioCentury BCIQFARP2
ClinGenFARP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9855
Chemical/Pharm GKB GenePA134873245
Clinical trialFARP2
Miscellaneous
canSAR (ICR)FARP2 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFARP2
EVEXFARP2
GoPubMedFARP2
iHOPFARP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:47:30 CET 2017

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