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FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial)

Identity

Alias_namesmitochondrial
FARS1
Alias_symbol (synonym)dJ236A3.1
Other aliasCOXPD14
HSPC320
PheRS
SPG77
HGNC (Hugo) FARS2
LocusID (NCBI) 10667
Atlas_Id 55978
Location 6p25.1  [Link to chromosome band 6p25]
Location_base_pair Starts at 5261326 and ends at 5771592 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BTBD9 (6p21.2) / FARS2 (6p25.1)DHX9 (1q25.3) / FARS2 (6p25.1)EXOC4 (7q33) / FARS2 (6p25.1)
FARS2 (6p25.1) / AKR1E2 (10p15.1)FARS2 (6p25.1) / BATF2 (11q13.1)FARS2 (6p25.1) / FARS2 (6p25.1)
FARS2 (6p25.1) / GCNT2 (6p24.3)FARS2 (6p25.1) / LOC402160 ()FARS2 (6p25.1) / PHACTR1 (6p24.1)
FARS2 (6p25.1) / PI4KB (1q21.3)FARS2 (6p25.1) / RREB1 (6p24.3)LOC402160 () / FARS2 (6p25.1)
LOC93622 (4p16.1) / FARS2 (6p25.1)SSR1 (6p24.3) / FARS2 (6p25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(6;6)(p21;p25) BTBD9/FARS2
t(6;6)(p24;p25) FARS2/GCNT2
t(6;6)(p24;p25) FARS2/PHACTR1
t(6;6)(p24;p25) FARS2/RREB1
t(6;6)(p24;p25) SSR1/FARS2
t(6;10)(p25;p15) FARS2/AKR1E2
t(6;11)(p25;q13) FARS2/BATF2


External links

Nomenclature
HGNC (Hugo)FARS2   21062
Cards
Entrez_Gene (NCBI)FARS2  10667  phenylalanyl-tRNA synthetase 2, mitochondrial
AliasesCOXPD14; FARS1; HSPC320; PheRS; 
SPG77
GeneCards (Weizmann)FARS2
Ensembl hg19 (Hinxton)ENSG00000145982 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145982 [Gene_View]  ENSG00000145982 [Sequence]  chr6:5261326-5771592 [Contig_View]  FARS2 [Vega]
ICGC DataPortalENSG00000145982
TCGA cBioPortalFARS2
AceView (NCBI)FARS2
Genatlas (Paris)FARS2
WikiGenes10667
SOURCE (Princeton)FARS2
Genetics Home Reference (NIH)FARS2
Genomic and cartography
GoldenPath hg38 (UCSC)FARS2  -     chr6:5261326-5771592 +  6p25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FARS2  -     6p25.1   [Description]    (hg19-Feb_2009)
EnsemblFARS2 - 6p25.1 [CytoView hg19]  FARS2 - 6p25.1 [CytoView hg38]
Mapping of homologs : NCBIFARS2 [Mapview hg19]  FARS2 [Mapview hg38]
OMIM611592   614946   617046   
Gene and transcription
Genbank (Entrez)AF097441 AF161438 AI338405 AK001146 AK223423
RefSeq transcript (Entrez)NM_001318872 NM_006567
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FARS2
Cluster EST : UnigeneHs.484547 [ NCBI ]
CGAP (NCI)Hs.484547
Alternative Splicing GalleryENSG00000145982
Gene ExpressionFARS2 [ NCBI-GEO ]   FARS2 [ EBI - ARRAY_EXPRESS ]   FARS2 [ SEEK ]   FARS2 [ MEM ]
Gene Expression Viewer (FireBrowse)FARS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10667
GTEX Portal (Tissue expression)FARS2
Human Protein AtlasENSG00000145982-FARS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95363   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95363  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95363
Splice isoforms : SwissVarO95363
PhosPhoSitePlusO95363
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)    FDX_ACB (PS51447)   
Domains : Interpro (EBI)aa-tRNA-synth_II    Fdx_antiC-bd    Fdx_antiC-bd_sf    Phe-tRNA-synth_IIc_mito    Phenylalanyl-tRNA_Synthase   
Domain families : Pfam (Sanger)FDX-ACB (PF03147)    tRNA-synt_2d (PF01409)   
Domain families : Pfam (NCBI)pfam03147    pfam01409   
Domain families : Smart (EMBL)FDX-ACB (SM00896)  
Conserved Domain (NCBI)FARS2
DMDM Disease mutations10667
Blocks (Seattle)FARS2
PDB (SRS)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
PDB (PDBSum)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
PDB (IMB)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
PDB (RSDB)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
Structural Biology KnowledgeBase3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
SCOP (Structural Classification of Proteins)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
CATH (Classification of proteins structures)3CMQ    3HFV    3TEG    3TUP    5MGH    5MGU    5MGV    5MGW   
SuperfamilyO95363
Human Protein Atlas [tissue]ENSG00000145982-FARS2 [tissue]
Peptide AtlasO95363
HPRD09946
IPIIPI00008579   IPI00645207   
Protein Interaction databases
DIP (DOE-UCLA)O95363
IntAct (EBI)O95363
FunCoupENSG00000145982
BioGRIDFARS2
STRING (EMBL)FARS2
ZODIACFARS2
Ontologies - Pathways
QuickGOO95363
Ontology : AmiGOtRNA binding  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  phenylalanyl-tRNA aminoacylation  phenylalanyl-tRNA aminoacylation  tRNA processing  
Ontology : EGO-EBItRNA binding  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  tRNA aminoacylation for protein translation  phenylalanyl-tRNA aminoacylation  phenylalanyl-tRNA aminoacylation  tRNA processing  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkFARS2
Atlas of Cancer Signalling NetworkFARS2
Wikipedia pathwaysFARS2
Orthology - Evolution
OrthoDB10667
GeneTree (enSembl)ENSG00000145982
Phylogenetic Trees/Animal Genes : TreeFamFARS2
HOVERGENO95363
HOGENOMO95363
Homologs : HomoloGeneFARS2
Homology/Alignments : Family Browser (UCSC)FARS2
Gene fusions - Rearrangements
Fusion : QuiverFARS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFARS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FARS2
dbVarFARS2
ClinVarFARS2
1000_GenomesFARS2 
Exome Variant ServerFARS2
ExAC (Exome Aggregation Consortium)ENSG00000145982
GNOMAD BrowserENSG00000145982
Varsome BrowserFARS2
Genetic variants : HAPMAP10667
Genomic Variants (DGV)FARS2 [DGVbeta]
DECIPHERFARS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFARS2 
Mutations
ICGC Data PortalFARS2 
TCGA Data PortalFARS2 
Broad Tumor PortalFARS2
OASIS PortalFARS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFARS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFARS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FARS2
DgiDB (Drug Gene Interaction Database)FARS2
DoCM (Curated mutations)FARS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FARS2 (select a term)
intoGenFARS2
Cancer3DFARS2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611592    614946    617046   
Orphanet21666   
DisGeNETFARS2
MedgenFARS2
Genetic Testing Registry FARS2
NextProtO95363 [Medical]
TSGene10667
GENETestsFARS2
Target ValidationFARS2
Huge Navigator FARS2 [HugePedia]
snp3D : Map Gene to Disease10667
BioCentury BCIQFARS2
ClinGenFARS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10667
Chemical/Pharm GKB GenePA134954893
Clinical trialFARS2
Miscellaneous
canSAR (ICR)FARS2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFARS2
EVEXFARS2
GoPubMedFARS2
iHOPFARS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:05:52 CET 2018

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