Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FARSA (phenylalanyl-tRNA synthetase subunit alpha)

Identity

Alias (NCBI)CML33
FARSL
FARSLA
FRSA
PheHA
HGNC (Hugo) FARSA
HGNC Alias symbCML33
HGNC Alias namephenylalanine tRNA ligase 1, alpha, cytoplasmic
HGNC Previous nameFARSL
 FARSLA
HGNC Previous namephenylalanine-tRNA synthetase-like
 phenylalanyl-tRNA synthetase-like, alpha subunit
LocusID (NCBI) 2193
Atlas_Id 40531
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12922479 and ends at 12933711 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FARSA (19p13.2) / AP1G2 (14q11.2)FARSA (19p13.2) / SYCE2 (19p13.2)FARSA 19p13.2 / AP1G2 14q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;19)(q11;p13) FARSA/AP1G2
FARSA/SYCE2 (19p13)

External links

Nomenclature
HGNC (Hugo)FARSA   3592
Cards
Entrez_Gene (NCBI)FARSA  2193  phenylalanyl-tRNA synthetase subunit alpha
AliasesCML33; FARSL; FARSLA; FRSA; 
PheHA
GeneCards (Weizmann)FARSA
Ensembl hg19 (Hinxton)ENSG00000179115 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179115 [Gene_View]  ENSG00000179115 [Sequence]  chr19:12922479-12933711 [Contig_View]  FARSA [Vega]
ICGC DataPortalENSG00000179115
TCGA cBioPortalFARSA
AceView (NCBI)FARSA
Genatlas (Paris)FARSA
WikiGenes2193
SOURCE (Princeton)FARSA
Genetics Home Reference (NIH)FARSA
Genomic and cartography
GoldenPath hg38 (UCSC)FARSA  -     chr19:12922479-12933711 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FARSA  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathFARSA - 19p13.13 [CytoView hg19]  FARSA - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000179115
genome Data Viewer NCBIFARSA [Mapview hg19]  
OMIM602918   
Gene and transcription
Genbank (Entrez)AF042347 AK092093 AK130195 AK304587 BC006495
RefSeq transcript (Entrez)NM_004461
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FARSA
Alternative Splicing GalleryENSG00000179115
Gene ExpressionFARSA [ NCBI-GEO ]   FARSA [ EBI - ARRAY_EXPRESS ]   FARSA [ SEEK ]   FARSA [ MEM ]
Gene Expression Viewer (FireBrowse)FARSA [ Firebrowse - Broad ]
GenevisibleExpression of FARSA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2193
GTEX Portal (Tissue expression)FARSA
Human Protein AtlasENSG00000179115-FARSA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y285   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y285  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y285
Splice isoforms : SwissVarQ9Y285
PhosPhoSitePlusQ9Y285
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_II (PS50862)   
Domains : Interpro (EBI)aa-tRNA-synth_II    Phe-tRNA-synth_IIc_asu    Phenylalanyl-tRNA_Synthase    PheRS_DBD1    PheRS_DBD2    PheRS_DBD3    WH_DNA-bd_sf   
Domain families : Pfam (Sanger)PheRS_DBD1 (PF18552)    PheRS_DBD2 (PF18554)    PheRS_DBD3 (PF18553)    tRNA-synt_2d (PF01409)   
Domain families : Pfam (NCBI)pfam18552    pfam18554    pfam18553    pfam01409   
Conserved Domain (NCBI)FARSA
DMDM Disease mutations2193
Blocks (Seattle)FARSA
PDB (RSDB)3L4G   
PDB Europe3L4G   
PDB (PDBSum)3L4G   
PDB (IMB)3L4G   
Structural Biology KnowledgeBase3L4G   
SCOP (Structural Classification of Proteins)3L4G   
CATH (Classification of proteins structures)3L4G   
SuperfamilyQ9Y285
Human Protein Atlas [tissue]ENSG00000179115-FARSA [tissue]
Peptide AtlasQ9Y285
HPRD04227
IPIIPI00031820   IPI00909657   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y285
IntAct (EBI)Q9Y285
FunCoupENSG00000179115
BioGRIDFARSA
STRING (EMBL)FARSA
ZODIACFARSA
Ontologies - Pathways
QuickGOQ9Y285
Ontology : AmiGOtRNA binding  RNA binding  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  phenylalanyl-tRNA aminoacylation  phenylalanyl-tRNA aminoacylation  phenylalanine-tRNA ligase complex  phenylalanine-tRNA ligase complex  membrane  protein heterotetramerization  
Ontology : EGO-EBItRNA binding  RNA binding  phenylalanine-tRNA ligase activity  phenylalanine-tRNA ligase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  phenylalanyl-tRNA aminoacylation  phenylalanyl-tRNA aminoacylation  phenylalanine-tRNA ligase complex  phenylalanine-tRNA ligase complex  membrane  protein heterotetramerization  
Pathways : KEGGAminoacyl-tRNA biosynthesis   
NDEx NetworkFARSA
Atlas of Cancer Signalling NetworkFARSA
Wikipedia pathwaysFARSA
Orthology - Evolution
OrthoDB2193
GeneTree (enSembl)ENSG00000179115
Phylogenetic Trees/Animal Genes : TreeFamFARSA
HOGENOMQ9Y285
Homologs : HomoloGeneFARSA
Homology/Alignments : Family Browser (UCSC)FARSA
Gene fusions - Rearrangements
Fusion : MitelmanFARSA/AP1G2 [19p13.2/14q11.2]  
Fusion PortalFARSA 19p13.2 AP1G2 14q11.2 HNSC
Fusion : QuiverFARSA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFARSA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FARSA
dbVarFARSA
ClinVarFARSA
MonarchFARSA
1000_GenomesFARSA 
Exome Variant ServerFARSA
GNOMAD BrowserENSG00000179115
Varsome BrowserFARSA
Genetic variants : HAPMAP2193
Genomic Variants (DGV)FARSA [DGVbeta]
DECIPHERFARSA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFARSA 
Mutations
ICGC Data PortalFARSA 
TCGA Data PortalFARSA 
Broad Tumor PortalFARSA
OASIS PortalFARSA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFARSA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFARSA
Mutations and Diseases : HGMDFARSA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FARSA
DgiDB (Drug Gene Interaction Database)FARSA
DoCM (Curated mutations)FARSA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FARSA (select a term)
intoGenFARSA
Cancer3DFARSA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602918   
Orphanet
DisGeNETFARSA
MedgenFARSA
Genetic Testing Registry FARSA
NextProtQ9Y285 [Medical]
TSGene2193
GENETestsFARSA
Target ValidationFARSA
Huge Navigator FARSA [HugePedia]
snp3D : Map Gene to Disease2193
BioCentury BCIQFARSA
ClinGenFARSA
Clinical trials, drugs, therapy
Protein Interactions : CTD2193
Pharm GKB GenePA28005
Clinical trialFARSA
Miscellaneous
canSAR (ICR)FARSA (select the gene name)
HarmonizomeFARSA
DataMed IndexFARSA
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFARSA
EVEXFARSA
GoPubMedFARSA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:10:58 CEST 2020
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