Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

FAS (Fas (TNF receptor superfamily, member 6))

Identity

Other namesALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
HGNC (Hugo) FAS
Location 10q23.31
Location_base_pair Starts at 90740268 and ends at 90765522 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FAS   11920
Entrez_Gene (NCBI)FAS  355  Fas (TNF receptor superfamily, member 6)
Cards
GeneCards (Weizmann)FAS
Ensembl (Hinxton)ENSG00000026103 [Gene_View]  FAS [Vega]
AceView (NCBI)FAS
Genatlas (Paris)FAS
euGene (Indiana)355
SOURCE (Stanford)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Gene Expression (Array Express) ENSG00000026103
Genomic and cartography
GoldenPath (UCSC)FAS  -  10q23.31   chr10:90740268-90765522 +  10q23.31   [Description]    (hg18-March_2006)
EnsemblFAS - 10q23.31 [CytoView]
Mapping of homologs : NCBIFAS [Mapview]
OMIM134637   601859   
Gene and transcription
Gene : Genbank (Entrez)AB209361 AK290978 AK311164 AK311424 AK311499
Reference sequence (RefSeq transcript) :SRSNM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Reference transcript : EntrezNM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
RefSeq genomic : SRSAC_000053 AC_000142 NC_000010 NG_009089 NT_030059 NW_001838005 NW_924884
RefSeq genomic : EntrezAC_000053 AC_000142 NC_000010 NG_009089 NT_030059 NW_001838005 NW_924884
Consensus coding sequences : CCDS NCBIFAS
Cluster EST : UnigeneHs.244139 [ SRS ] Hs.244139 [ NCBI ]
Alternative Splicing : Fast-db (Paris)15295
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP25445 (SRS) P25445 (Expasy) P25445 (Uniprot)
With graphics : InterProP25445
Splice isoforms : VarSplice FASTAP25445(VarSplice FASTA)
Domaine pattern : Prosite (SRS)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domain pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (SRS)Death    DEATH-like    Fas_rcpt    TNFR_Cys_rich_reg   
Domains : Interpro (EBI)Death    DEATH-like    Fas_rcpt    TNFR_Cys_rich_reg   
Related proteins : CluSTrP25445
Domain families : Pfam SRSDeath (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam SangerDeath (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam NCBIpfam00531    pfam00020   
Domain families : Smart EMBLDEATH (SM00005)  TNFR (SM00208)  
Blocks (Seattle)P25445
Crystal structure of protein : PDB SRS1BZI    1DDF    3EWT    3EZQ   
Crystal structure of protein : PDBSum1BZI    1DDF    3EWT    3EZQ   
Crystal structure of protein : IMB1BZI    1DDF    3EWT    3EZQ   
Crystal structure of protein : PDB RSDB1BZI    1DDF    3EWT    3EZQ   
HPRD00609
Protein Interaction databases
DIP (DOE-UCLA)P25445
IntAct (EBI)P25445
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIFAS
SNP : GeneSNP UtahFAS
SNP : HGBaseFAS
Genetic variants : HAPMAPFAS
Somatic Mutations in Cancer : COSMICFAS 
Mutations and Diseases : HGMDFAS
Hereditary diseases : OMIM134637    601859   
Hereditary diseases : GENETests134637    601859   
Diseases : Genetic AssociationFAS
General knowledge
Homologs : HomoloGeneFAS
Homology/Alignments : Family Browser UCSCFAS
Phylogenetic Trees/Animal Genes : TreeFamFAS
Chemical/Protein Interactions : CTD355
Keywords Ontology : AmiGOtransmembrane receptor activity  extracellular region  soluble fraction  cytosol  plasma membrane  protein complex assembly  anti-apoptosis  immune response  signal transduction  induction of apoptosis by extracellular signals  activation of pro-apoptotic gene products  positive regulation of necrotic cell death  integral to membrane  kinase binding  death-inducing signaling complex  identical protein binding  regulation of apoptosis  
Keywords Ontology : EGO-EBItransmembrane receptor activity  extracellular region  soluble fraction  cytosol  plasma membrane  protein complex assembly  anti-apoptosis  immune response  signal transduction  induction of apoptosis by extracellular signals  activation of pro-apoptotic gene products  positive regulation of necrotic cell death  integral to membrane  kinase binding  death-inducing signaling complex  identical protein binding  regulation of apoptosis  
Pathways : BIOCARTAHIV-I Nef: negative effector of Fas and TNF [Genes]    Antigen Dependent B Cell Activation [Genes]    Bystander B Cell Activation [Genes]    CTL mediated immune response against target cells [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Stress Induction of HSP Regulation [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Keratinocyte Differentiation [Genes]    Regulation of transcriptional activity by PML [Genes]    HIV Induced T Cell Apoptosis [Genes]   
Pathways : KEGGMAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisNatural killer cell mediated cytotoxicityType I diabetes mellitus
Other databases
Probes
Probes : ImagenesFAS Related clones (RZPD - Berlin)
Literature
PubMed499 Pubmed reference(s) in Entrez
PubGeneFAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:43:29 CET 2010
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.