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FAS (Fas cell surface death receptor)

Identity

Other namesALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
HGNC (Hugo) FAS
LocusID (NCBI) 355
Location 10q23.31
Location_base_pair Starts at 90750288 and ends at 90775542 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945 MedulloblastomaID5065

External links

Nomenclature
HGNC (Hugo)FAS   11920
Cards
Entrez_Gene (NCBI)FAS  355  Fas cell surface death receptor
GeneCards (Weizmann)FAS
Ensembl (Hinxton)ENSG00000026103 [Gene_View]  chr10:90750288-90775542 [Contig_View]  FAS [Vega]
ICGC DataPortalENSG00000026103
AceView (NCBI)FAS
Genatlas (Paris)FAS
WikiGenes355
SOURCE (Princeton)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Genomic and cartography
GoldenPath (UCSC)FAS  -  10q23.31   chr10:90750288-90775542 +  10q23.31   [Description]    (hg19-Feb_2009)
EnsemblFAS - 10q23.31 [CytoView]
Mapping of homologs : NCBIFAS [Mapview]
OMIM134637   601859   
Gene and transcription
Genbank (Entrez)AB209361 AK026195 AK290978 AK311164 AK311424
RefSeq transcript (Entrez)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_009089 NT_030059 NW_001838005 NW_004929376
Consensus coding sequences : CCDS (NCBI)FAS
Cluster EST : UnigeneHs.667309 [ NCBI ]
CGAP (NCI)Hs.667309
Alternative Splicing : Fast-db (Paris)GSHG0033148
Alternative Splicing GalleryENSG00000026103
Gene ExpressionFAS [ NCBI-GEO ]     FAS [ SEEK ]   FAS [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25445 (Uniprot)
NextProtP25445  [Medical]
With graphics : InterProP25445
Splice isoforms : SwissVarP25445 (Swissvar)
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    Fas_rcpt    TNFR/NGFR_Cys_rich_reg   
Related proteins : CluSTrP25445
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM Disease mutations355
Blocks (Seattle)P25445
PDB (SRS)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (PDBSum)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (IMB)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (RSDB)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
Human Protein AtlasENSG00000026103
Peptide AtlasP25445
HPRD00609
IPIIPI00744894   IPI00216357   IPI00216358   IPI00216359   IPI00170811   IPI00291314   IPI00375340   IPI00235003   IPI00966251   
Protein Interaction databases
DIP (DOE-UCLA)P25445
IntAct (EBI)P25445
FunCoupENSG00000026103
BioGRIDFAS
InParanoidP25445
Interologous Interaction database P25445
IntegromeDBFAS
STRING (EMBL)FAS
Ontologies - Pathways
Ontology : AmiGOimmunoglobulin production  renal system process  signal transducer activity  receptor activity  transmembrane signaling receptor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  plasma membrane  protein complex assembly  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation-induced cell death of T cells  inflammatory cell apoptotic process  transformed cell apoptotic process  signal transduction  extrinsic apoptotic signaling pathway via death domain receptors  response to toxic substance  external side of plasma membrane  cell surface  integral component of membrane  B cell mediated immunity  kinase binding  death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of protein homooligomerization  identical protein binding  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative thymic T cell selection  membrane raft  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  spleen development  negative regulation of B cell activation  protein homooligomerization  response to glucocorticoid  extracellular vesicular exosome  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to hyperoxia  motor neuron apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIimmunoglobulin production  renal system process  signal transducer activity  receptor activity  transmembrane signaling receptor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  plasma membrane  protein complex assembly  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation-induced cell death of T cells  inflammatory cell apoptotic process  transformed cell apoptotic process  signal transduction  extrinsic apoptotic signaling pathway via death domain receptors  response to toxic substance  external side of plasma membrane  cell surface  integral component of membrane  B cell mediated immunity  kinase binding  death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of protein homooligomerization  identical protein binding  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  negative thymic T cell selection  membrane raft  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  spleen development  negative regulation of B cell activation  protein homooligomerization  response to glucocorticoid  extracellular vesicular exosome  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to hyperoxia  motor neuron apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  necroptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway in absence of ligand  positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAStress Induction of HSP Regulation [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Bystander B Cell Activation [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Keratinocyte Differentiation [Genes]    CTL mediated immune response against target cells [Genes]    Regulation of transcriptional activity by PML [Genes]    Antigen Dependent B Cell Activation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    HIV Induced T Cell Apoptosis [Genes]   
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    p53 signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    TNF signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Alzheimer's disease    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Pathways in cancer    Proteoglycans in cancer    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease   
Protein Interaction DatabaseFAS
Wikipedia pathwaysFAS
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FAS
SNP (GeneSNP Utah)FAS
SNP : HGBaseFAS
Genetic variants : HAPMAPFAS
1000_GenomesFAS 
ICGC programENSG00000026103 
Cancer Gene: CensusFAS 
CONAN: Copy Number AnalysisFAS 
Somatic Mutations in Cancer : COSMICFAS 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
LOVD (Leiden Open Variation Database)LOVD at NCBI
Mutations and Diseases : HGMDFAS
OMIM134637    601859   
MedgenFAS
GENETestsFAS
Disease Genetic AssociationFAS
Huge Navigator FAS [HugePedia]  FAS [HugeCancerGEM]
Genomic VariantsFAS  FAS [DGVbeta]
Exome VariantFAS
dbVarFAS
ClinVarFAS
snp3D : Map Gene to Disease355
General knowledge
Homologs : HomoloGeneFAS
Homology/Alignments : Family Browser (UCSC)FAS
Phylogenetic Trees/Animal Genes : TreeFamFAS
Chemical/Protein Interactions : CTD355
Chemical/Pharm GKB GenePA36613
Clinical trialFAS
Cancer Resource (Charite)ENSG00000026103
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineFAS
iHOPFAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:45:57 CEST 2014

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