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FAS (Fas (TNF receptor superfamily, member 6))

Identity

Other namesALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
HGNC (Hugo) FAS
LocusID (NCBI) 355
Location 10q23.31
Location_base_pair Starts at 90750288 and ends at 90775542 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FAS   11920
Entrez_Gene (NCBI)FAS  355  Fas (TNF receptor superfamily, member 6)
Cards
GeneCards (Weizmann)FAS
Ensembl (Hinxton)ENSG00000026103 [Gene_View]  chr10:90750288-90775542 [Contig_View]  FAS [Vega]
AceView (NCBI)FAS
Genatlas (Paris)FAS
SOURCE (Stanford)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
Genomic and cartography
GoldenPath (UCSC)FAS  -  10q23.31   chr10:90750288-90775542 +  10q23.31   [Description]    (hg19-Feb_2009)
EnsemblFAS - 10q23.31 [CytoView]
Mapping of homologs : NCBIFAS [Mapview]
OMIM134637   601859   
Gene and transcription
Genbank (Entrez)AB209361 AK290978 AK311164 AK311424 AK311499
RefSeq transcript (SRS)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
RefSeq transcript (Entrez)NM_000043 NM_152871 NM_152872 NM_152873 NM_152874 NM_152875 NM_152876 NM_152877
RefSeq genomic (SRS)AC_000142 NC_000010 NC_018921 NG_009089 NT_030059 NW_001838005 NW_004078068
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NG_009089 NT_030059 NW_001838005 NW_004078068
Consensus coding sequences : CCDS (NCBI)FAS
Cluster EST : UnigeneHs.244139 [ SRS ] Hs.244139 [ NCBI ]
CGAP (NCI)Hs.244139
Alternative Splicing : Fast-db (Paris)GSHG0033148
Alternative Splicing GalleryENSG00000026103
Gene ExpressionFAS [ NCBI-GEO ]   FAS [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25445 (SRS) P25445 (Uniprot)
NextProtP25445
With graphics : InterProP25445
Splice isoforms : SwissVarP25445(Swissvar)
Domaine pattern : Prosite (SRS)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (SRS)Death    DEATH-like    Fas_rcpt    TNFR/NGFR_Cys_rich_reg   
Domains : Interpro (EBI)Death    DEATH-like    Fas_rcpt    TNFR/NGFR_Cys_rich_reg   
Related proteins : CluSTrP25445
Domain families : Pfam (SRS)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM355
Blocks (Seattle)P25445
PDB (SRS)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (PDBSum)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (IMB)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
PDB (RSDB)1BZI    1DDF    3EWT    3EZQ    3THM    3TJE   
Human Protein AtlasENSG00000026103
HPRD00609
IPIIPI00744894   IPI00216357   IPI00216358   IPI00216359   IPI00170811   IPI00291314   IPI00375340   IPI00235003   IPI00966251   
Protein Interaction databases
DIP (DOE-UCLA)P25445
IntAct (EBI)P25445
FunCoupENSG00000026103
REACTOMEFAS
Protein Interaction Database355
BioGRIDFAS
InParanoidP25445
Interologous Interaction database P25445
IntegromeDBFAS
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FAS
SNP (GeneSNP Utah)FAS
SNP : HGBaseFAS
Genetic variants : HAPMAPFAS
Somatic Mutations in Cancer : COSMICFAS 
CONAN: Copy Number AnalysisFAS 
Mutations and Diseases : HGMDFAS
OMIM134637    601859   
GENETests134637    601859   
Disease Genetic AssociationFAS
Huge Navigator FAS [HugePedia]  FAS [HugeCancerGEM]
Genomic VariantsFAS  FAS [DGVbeta]
snp3D : Map Gene to Disease355
General knowledge
Homologs : HomoloGeneFAS
Homology/Alignments : Family Browser (UCSC)FAS
Phylogenetic Trees/Animal Genes : TreeFamFAS
Chemical/Protein Interactions : CTD355
Chemical/Pharm GKB GenePA36613
Clinical trialFAS
Cancer Resource (Charite)ENSG00000026103
Ontology : AmiGOresponse to hypoxia  immunoglobulin production  renal system process  signal transducer activity  receptor activity  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  protein complex assembly  apoptotic process  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation-induced cell death of T cells  inflammatory cell apoptotic process  transformed cell apoptotic process  signal transduction  spermatogenesis  aging  extrinsic apoptotic signaling pathway via death domain receptors  response to toxin  external side of plasma membrane  gene expression  positive regulation of necrotic cell death  integral to membrane  B cell mediated immunity  kinase binding  dendrite regeneration  death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of protein homooligomerization  response to lipopolysaccharide  regulation of cell proliferation  response to drug  ovulation cycle  identical protein binding  regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  response to peptide hormone stimulus  response to estrogen stimulus  negative thymic T cell selection  membrane raft  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  perinuclear region of cytoplasm  spleen development  negative regulation of B cell activation  protein homooligomerization  response to glucocorticoid stimulus  neuron apoptotic process  response to growth factor stimulus  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to hyperoxia  
Ontology : EGO-EBIresponse to hypoxia  immunoglobulin production  renal system process  signal transducer activity  receptor activity  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  protein complex assembly  apoptotic process  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation-induced cell death of T cells  inflammatory cell apoptotic process  transformed cell apoptotic process  signal transduction  spermatogenesis  aging  extrinsic apoptotic signaling pathway via death domain receptors  response to toxin  external side of plasma membrane  gene expression  positive regulation of necrotic cell death  integral to membrane  B cell mediated immunity  kinase binding  dendrite regeneration  death-inducing signaling complex  CD95 death-inducing signaling complex  positive regulation of protein homooligomerization  response to lipopolysaccharide  regulation of cell proliferation  response to drug  ovulation cycle  identical protein binding  regulation of apoptotic process  positive regulation of apoptotic process  negative regulation of apoptotic process  response to peptide hormone stimulus  response to estrogen stimulus  negative thymic T cell selection  membrane raft  regulation of lymphocyte differentiation  regulation of myeloid cell differentiation  perinuclear region of cytoplasm  spleen development  negative regulation of B cell activation  protein homooligomerization  response to glucocorticoid stimulus  neuron apoptotic process  response to growth factor stimulus  cellular response to mechanical stimulus  cellular response to lithium ion  cellular response to hyperoxia  
Pathways : BIOCARTAStress Induction of HSP Regulation [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    Bystander B Cell Activation [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Keratinocyte Differentiation [Genes]    CTL mediated immune response against target cells [Genes]    Regulation of transcriptional activity by PML [Genes]    Antigen Dependent B Cell Activation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    HIV Induced T Cell Apoptosis [Genes]   
Pathways : KEGGApoptosisMAPK signaling pathwayCytokine-cytokine receptor interactionType I diabetes mellitusNatural killer cell mediated cytotoxicity
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
PubGeneFAS
iHOPFAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:45:49 CEST 2013

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