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FASLG (Fas ligand (TNF superfamily, member 6))

Identity

Other namesALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
HGNC (Hugo) FASLG
LocusID (NCBI) 356
Location 1q24.3
Location_base_pair Starts at 172628185 and ends at 172636012 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FASLG   11936
Cards
Entrez_Gene (NCBI)FASLG  356  Fas ligand (TNF superfamily, member 6)
GeneCards (Weizmann)FASLG
Ensembl hg19 (Hinxton)ENSG00000117560 [Gene_View]  chr1:172628185-172636012 [Contig_View]  FASLG [Vega]
Ensembl hg38 (Hinxton)ENSG00000117560 [Gene_View]  chr1:172628185-172636012 [Contig_View]  FASLG [Vega]
ICGC DataPortalENSG00000117560
cBioPortalFASLG
AceView (NCBI)FASLG
Genatlas (Paris)FASLG
WikiGenes356
SOURCE (Princeton)FASLG
Genomic and cartography
GoldenPath hg19 (UCSC)FASLG  -     chr1:172628185-172636012 +  1q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FASLG  -     1q24.3   [Description]    (hg38-Dec_2013)
EnsemblFASLG - 1q24.3 [CytoView hg19]  FASLG - 1q24.3 [CytoView hg38]
Mapping of homologs : NCBIFASLG [Mapview hg19]  FASLG [Mapview hg38]
OMIM134638   211980   601859   
Gene and transcription
Genbank (Entrez)AF288573 AK314874 AY225406 AY858799 BC017502
RefSeq transcript (Entrez)NM_000639
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007269 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)FASLG
Cluster EST : UnigeneHs.2007 [ NCBI ]
CGAP (NCI)Hs.2007
Alternative Splicing : Fast-db (Paris)GSHG0001195
Alternative Splicing GalleryENSG00000117560
Gene ExpressionFASLG [ NCBI-GEO ]     FASLG [ SEEK ]   FASLG [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48023 (Uniprot)
NextProtP48023  [Medical]
With graphics : InterProP48023
Splice isoforms : SwissVarP48023 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)FASL    TNF    TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Related proteins : CluSTrP48023
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations356
Blocks (Seattle)P48023
PDB (SRS)1BZI    4MSV   
PDB (PDBSum)1BZI    4MSV   
PDB (IMB)1BZI    4MSV   
PDB (RSDB)1BZI    4MSV   
Human Protein AtlasENSG00000117560
Peptide AtlasP48023
HPRD00610
IPIIPI00007577   IPI00220870   
Protein Interaction databases
DIP (DOE-UCLA)P48023
IntAct (EBI)P48023
FunCoupENSG00000117560
BioGRIDFASLG
IntegromeDBFASLG
STRING (EMBL)FASLG
Ontologies - Pathways
QuickGOP48023
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  integral component of plasma membrane  caveola  transcription, DNA-templated  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cellular chloride ion homeostasis  response to lipopolysaccharide  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic membrane-bounded vesicle lumen  extracellular vesicular exosome  T cell apoptotic process  necroptotic process  response to growth factor  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  positive regulation of endothelial cell apoptotic process  regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  integral component of plasma membrane  caveola  transcription, DNA-templated  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cellular chloride ion homeostasis  response to lipopolysaccharide  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic membrane-bounded vesicle lumen  extracellular vesicular exosome  T cell apoptotic process  necroptotic process  response to growth factor  apoptotic signaling pathway  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  necroptotic signaling pathway  positive regulation of endothelial cell apoptotic process  regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTACTL mediated immune response against target cells [Genes]    Regulation of transcriptional activity by PML [Genes]    Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes]    Antigen Dependent B Cell Activation [Genes]    Bystander B Cell Activation [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Stress Induction of HSP Regulation [Genes]    Keratinocyte Differentiation [Genes]    HIV Induced T Cell Apoptosis [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    AKT Signaling Pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]   
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Cytokine-cytokine receptor interaction    FoxO signaling pathway    PI3K-Akt signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    Neurotrophin signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Type I diabetes mellitus    Chagas disease (American trypanosomiasis)    African trypanosomiasis    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Pathways in cancer    Proteoglycans in cancer    Autoimmune thyroid disease    Allograft rejection    Graft-versus-host disease   
Protein Interaction DatabaseFASLG
DoCM (Curated mutations)FASLG
Wikipedia pathwaysFASLG
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerFASLG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FASLG
dbVarFASLG
ClinVarFASLG
1000_GenomesFASLG 
Exome Variant ServerFASLG
SNP (GeneSNP Utah)FASLG
SNP : HGBaseFASLG
Genetic variants : HAPMAPFASLG
Genomic VariantsFASLG  FASLG [DGVbeta]
Mutations
ICGC Data PortalENSG00000117560 
Somatic Mutations in Cancer : COSMICFASLG 
CONAN: Copy Number AnalysisFASLG 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:172628185-172636012
Mutations and Diseases : HGMDFASLG
OMIM134638    211980    601859   
MedgenFASLG
NextProtP48023 [Medical]
GENETestsFASLG
Disease Genetic AssociationFASLG
Huge Navigator FASLG [HugePedia]  FASLG [HugeCancerGEM]
snp3D : Map Gene to Disease356
DGIdb (Drug Gene Interaction db)FASLG
General knowledge
Homologs : HomoloGeneFASLG
Homology/Alignments : Family Browser (UCSC)FASLG
Phylogenetic Trees/Animal Genes : TreeFamFASLG
Chemical/Protein Interactions : CTD356
Chemical/Pharm GKB GenePA56
Clinical trialFASLG
Cancer Resource (Charite)ENSG00000117560
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineFASLG
GoPubMedFASLG
iHOPFASLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:32:10 CET 2014

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