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FASLG (Fas ligand (TNF superfamily, member 6))

Identity

Other namesALPS1B
APT1LG1
CD178
CD95-L
CD95L
FASL
TNFSF6
HGNC (Hugo) FASLG
LocusID (NCBI) 356
Location 1q24.3
Location_base_pair Starts at 172628185 and ends at 172636012 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FASLG   11936
Entrez_Gene (NCBI)FASLG  356  Fas ligand (TNF superfamily, member 6)
Cards
GeneCards (Weizmann)FASLG
Ensembl (Hinxton)ENSG00000117560 [Gene_View]  chr1:172628185-172636012 [Contig_View]  FASLG [Vega]
AceView (NCBI)FASLG
Genatlas (Paris)FASLG
SOURCE (Stanford)NM_000639
Genomic and cartography
GoldenPath (UCSC)FASLG  -  1q24.3   chr1:172628185-172636012 +  1q24.3   [Description]    (hg19-Feb_2009)
EnsemblFASLG - 1q24.3 [CytoView]
Mapping of homologs : NCBIFASLG [Mapview]
OMIM134638   152700   211980   212980   601859   
Gene and transcription
Genbank (Entrez)AF288573 AK314874 AY225406 AY858799 BC017502
RefSeq transcript (SRS)NM_000639
RefSeq transcript (Entrez)NM_000639
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NG_007269 NT_004487 NW_001838533 NW_004077999
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007269 NT_004487 NW_001838533 NW_004077999
Consensus coding sequences : CCDS (NCBI)FASLG
Cluster EST : UnigeneHs.2007 [ SRS ] Hs.2007 [ NCBI ]
CGAP (NCI)Hs.2007
Alternative Splicing : Fast-db (Paris)GSHG0001195
Alternative Splicing GalleryENSG00000117560
Gene ExpressionFASLG [ NCBI-GEO ]   FASLG [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48023 (SRS) P48023 (Uniprot)
NextProtP48023
With graphics : InterProP48023
Splice isoforms : SwissVarP48023(Swissvar)
Domaine pattern : Prosite (SRS)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (SRS)Fas_ligand    TNF    TNF_a/b/c    TNF_CS    Tumour_necrosis_fac-like   
Domains : Interpro (EBI)Fas_ligand    TNF    TNF_a/b/c    TNF_CS    Tumour_necrosis_fac-like   
Related proteins : CluSTrP48023
Domain families : Pfam (SRS)TNF (PF00229)   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM356
Blocks (Seattle)P48023
PDB (SRS)1BZI   
PDB (PDBSum)1BZI   
PDB (IMB)1BZI   
PDB (RSDB)1BZI   
Human Protein AtlasENSG00000117560
HPRD00610
IPIIPI00007577   IPI00220870   
Protein Interaction databases
DIP (DOE-UCLA)P48023
IntAct (EBI)P48023
FunCoupENSG00000117560
REACTOMEFASLG
Protein Interaction Database356
BioGRIDFASLG
InParanoidP48023
Interologous Interaction database P48023
IntegromeDBFASLG
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)FASLG
SNP (GeneSNP Utah)FASLG
SNP : HGBaseFASLG
Genetic variants : HAPMAPFASLG
Somatic Mutations in Cancer : COSMICFASLG 
CONAN: Copy Number AnalysisFASLG 
Mutations and Diseases : HGMDFASLG
OMIM134638    152700    211980    212980    601859   
GENETests134638    152700    211980    212980    601859   
Disease Genetic AssociationFASLG
Huge Navigator FASLG [HugePedia]  FASLG [HugeCancerGEM]
Genomic VariantsFASLG  FASLG [DGVbeta]
snp3D : Map Gene to Disease356
General knowledge
Homologs : HomoloGeneFASLG
Homology/Alignments : Family Browser (UCSC)FASLG
Phylogenetic Trees/Animal Genes : TreeFamFASLG
Chemical/Protein Interactions : CTD356
Chemical/Pharm GKB GenePA56
Clinical trialFASLG
Cancer Resource (Charite)ENSG00000117560
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  integral to plasma membrane  caveola  transcription, DNA-dependent  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cellular chloride ion homeostasis  response to lipopolysaccharide  cellular response to stress  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic membrane-bounded vesicle lumen  activation of necroptosis of activated-T cells  activation of necroptosis by extracellular signals  extracellular vesicular exosome  necrotic cell death  response to growth factor stimulus  apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  integral to plasma membrane  caveola  transcription, DNA-dependent  apoptotic process  induction of apoptosis  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory cell apoptotic process  immune response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  negative regulation of angiogenesis  cellular chloride ion homeostasis  response to lipopolysaccharide  cellular response to stress  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB cascade  lysosomal lumen  positive regulation of neuron apoptotic process  positive regulation of epidermal growth factor receptor signaling pathway  retinal cell programmed cell death  endosomal lumen acidification  perinuclear region of cytoplasm  cytoplasmic membrane-bounded vesicle lumen  activation of necroptosis of activated-T cells  activation of necroptosis by extracellular signals  extracellular vesicular exosome  necrotic cell death  response to growth factor stimulus  apoptotic signaling pathway  
Pathways : BIOCARTACTL mediated immune response against target cells [Genes]    Regulation of transcriptional activity by PML [Genes]    Role of nicotinic acetylcholine receptors in the regulation of apoptosis [Genes]    Antigen Dependent B Cell Activation [Genes]    Bystander B Cell Activation [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Stress Induction of HSP Regulation [Genes]    Keratinocyte Differentiation [Genes]    HIV Induced T Cell Apoptosis [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    AKT Signaling Pathway [Genes]    IL-2 Receptor Beta Chain in T cell Activation [Genes]    PTEN dependent cell cycle arrest and apoptosis [Genes]   
Pathways : KEGGType I diabetes mellitusNatural killer cell mediated cytotoxicityMAPK signaling pathwayApoptosisCytokine-cytokine receptor interaction
Other databases
Probes
Litterature
PubMed478 Pubmed reference(s) in Entrez
PubGeneFASLG
iHOPFASLG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:28:12 CEST 2013
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