FASN (fatty acid synthase)

2003-06-01  

Identity

HGNC
FASN
LOCATION
17q25.3
LOCUSID
2194
ALIAS
FAS,OA-519,SDR27X1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2194
MIM: 600212
HGNC: 3594
Ensembl: ENSG00000169710

Variants:

dbSNP: 2194
ClinVar: 2194
TCGA: ENSG00000169710
COSMIC: FASN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169710ENST00000306749P49327
ENSG00000169710ENST00000580382J3KTF0
ENSG00000169710ENST00000634990A0A0U1RQF0
ENSG00000169710ENST00000635197A0A0U1RRG3
ENSG00000169710ENST00000636628A0A1B0GWG8
ENSG00000169710ENST00000636968A0A1B0GVK4
ENSG00000169710ENST00000637026A0A1B0GTR5

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Insulin signaling pathwayKEGGko04910
Fatty acid biosynthesisKEGGhsa00061
Insulin signaling pathwayKEGGhsa04910
Metabolic pathwaysKEGGhsa01100
Fatty acid biosynthesis, elongationKEGGhsa_M00083
Fatty acid biosynthesis, initiationKEGGM00082
Fatty acid biosynthesis, elongationKEGGM00083
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
Fatty acid biosynthesis, initiationKEGGhsa_M00082
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168
Integration of energy metabolismREACTOMER-HSA-163685
ChREBP activates metabolic gene expressionREACTOMER-HSA-163765
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin B5 (pantothenate) metabolismREACTOMER-HSA-199220

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
117907872002Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.173
193186312009Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancer.130
182814742008Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.122
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
129393962003Fatty acid synthase expression defines distinct molecular signatures in prostate cancer.84
146895812004Fatty acid synthase: a metabolic oncogene in prostate cancer?78
152351252004Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells.77
176315002007Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells.76
128399762003RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells.74
189554442008Cohort study of fatty acid synthase expression and patient survival in colon cancer.74

Citation

Dessen P

FASN (fatty acid synthase)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40532/fasn