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FASN (fatty acid synthase)

Identity

Alias_namesmember 1
Alias_symbol (synonym)FAS
SDR27X1
Other aliasOA-519
HGNC (Hugo) FASN
LocusID (NCBI) 2194
Atlas_Id 40532
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82078338 and ends at 82098230 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FASN (17q25.3) / CCDC57 (17q25.3)FASN (17q25.3) / ESR1 (6q25.1)FASN (17q25.3) / LAMB1 (7q31.1)
FASN (17q25.3) / ZNF595 (4p16.3)FBXL15 (10q24.32) / FASN (17q25.3)FBXO9 (6p12.1) / FASN (17q25.3)
HTT (4p16.3) / FASN (17q25.3)LOC100507424 (12p13.33) / FASN (17q25.3)TMEM259 (19p13.3) / FASN (17q25.3)
FASN 17q25.3 / CCDC57 17q25.3FASN 17q25.3 / ZNF595 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FASN   3594
Cards
Entrez_Gene (NCBI)FASN  2194  fatty acid synthase
AliasesFAS; OA-519; SDR27X1
GeneCards (Weizmann)FASN
Ensembl hg19 (Hinxton)ENSG00000169710 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169710 [Gene_View]  chr17:82078338-82098230 [Contig_View]  FASN [Vega]
ICGC DataPortalENSG00000169710
TCGA cBioPortalFASN
AceView (NCBI)FASN
Genatlas (Paris)FASN
WikiGenes2194
SOURCE (Princeton)FASN
Genetics Home Reference (NIH)FASN
Genomic and cartography
GoldenPath hg38 (UCSC)FASN  -     chr17:82078338-82098230 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FASN  -     17q25.3   [Description]    (hg19-Feb_2009)
EnsemblFASN - 17q25.3 [CytoView hg19]  FASN - 17q25.3 [CytoView hg38]
Mapping of homologs : NCBIFASN [Mapview hg19]  FASN [Mapview hg38]
OMIM600212   
Gene and transcription
Genbank (Entrez)AB209988 AY451392 BC007267 BC007305 BC007909
RefSeq transcript (Entrez)NM_004104
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FASN
Cluster EST : UnigeneHs.83190 [ NCBI ]
CGAP (NCI)Hs.83190
Alternative Splicing GalleryENSG00000169710
Gene ExpressionFASN [ NCBI-GEO ]   FASN [ EBI - ARRAY_EXPRESS ]   FASN [ SEEK ]   FASN [ MEM ]
Gene Expression Viewer (FireBrowse)FASN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2194
GTEX Portal (Tissue expression)FASN
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49327   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49327  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49327
Splice isoforms : SwissVarP49327
Catalytic activity : Enzyme2.3.1.85 [ Enzyme-Expasy ]   2.3.1.852.3.1.85 [ IntEnz-EBI ]   2.3.1.85 [ BRENDA ]   2.3.1.85 [ KEGG ]   
PhosPhoSitePlusP49327
Domaine pattern : Prosite (Expaxy)B_KETOACYL_SYNTHASE (PS00606)    CARRIER (PS50075)    PHOSPHOPANTETHEINE (PS00012)   
Domains : Interpro (EBI)###############################################################################################################################################################################################################################################################                                                                                                   
Domain families : Pfam (Sanger)Acyl_transf_1 (PF00698)    ADH_zinc_N (PF00107)    KAsynt_C_assoc (PF16197)    ketoacyl-synt (PF00109)    Ketoacyl-synt_C (PF02801)    KR (PF08659)    Methyltransf_12 (PF08242)    PP-binding (PF00550)    PS-DH (PF14765)    Thioesterase (PF00975)   
Domain families : Pfam (NCBI)pfam00698    pfam00107    pfam16197    pfam00109    pfam02801    pfam08659    pfam08242    pfam00550    pfam14765    pfam00975   
Domain families : Smart (EMBL)PKS_AT (SM00827)  PKS_DH (SM00826)  PKS_ER (SM00829)  PKS_KS (SM00825)  PKS_PP (SM00823)  
Conserved Domain (NCBI)FASN
DMDM Disease mutations2194
Blocks (Seattle)FASN
PDB (SRS)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
PDB (PDBSum)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
PDB (IMB)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
PDB (RSDB)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
Structural Biology KnowledgeBase1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
SCOP (Structural Classification of Proteins)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
CATH (Classification of proteins structures)1XKT    2CG5    2JFD    2JFK    2PX6    3HHD    3TJM    4PIV    4W82    4W9N    4Z49    5C37   
SuperfamilyP49327
Human Protein AtlasENSG00000169710
Peptide AtlasP49327
HPRD02567
IPIIPI00026781   IPI01010171   
Protein Interaction databases
DIP (DOE-UCLA)P49327
IntAct (EBI)P49327
FunCoupENSG00000169710
BioGRIDFASN
STRING (EMBL)FASN
ZODIACFASN
Ontologies - Pathways
QuickGOP49327
Ontology : AmiGOosteoblast differentiation  RNA binding  fatty acid synthase activity  [acyl-carrier-protein] S-acetyltransferase activity  [acyl-carrier-protein] S-malonyltransferase activity  3-oxoacyl-[acyl-carrier-protein] synthase activity  3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity  3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity  enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity  oleoyl-[acyl-carrier-protein] hydrolase activity  protein binding  mitochondrion  Golgi apparatus  cytosol  cytosol  plasma membrane  acetyl-CoA metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  drug binding  pantothenate metabolic process  membrane  myristoyl-[acyl-carrier-protein] hydrolase activity  palmitoyl-[acyl-carrier-protein] hydrolase activity  mammary gland development  phosphopantetheine binding  positive regulation of cellular metabolic process  long-chain fatty-acyl-CoA biosynthetic process  melanosome  glycogen granule  protein homodimerization activity  cadherin binding  enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity  3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity  oxidation-reduction process  extracellular exosome  NADPH binding  cellular response to interleukin-4  3-oxo-glutaryl-[acp] methyl ester reductase activity  3-oxo-pimeloyl-[acp] methyl ester reductase activity  
Ontology : EGO-EBIosteoblast differentiation  RNA binding  fatty acid synthase activity  [acyl-carrier-protein] S-acetyltransferase activity  [acyl-carrier-protein] S-malonyltransferase activity  3-oxoacyl-[acyl-carrier-protein] synthase activity  3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity  3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity  enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity  oleoyl-[acyl-carrier-protein] hydrolase activity  protein binding  mitochondrion  Golgi apparatus  cytosol  cytosol  plasma membrane  acetyl-CoA metabolic process  fatty acid metabolic process  fatty acid biosynthetic process  drug binding  pantothenate metabolic process  membrane  myristoyl-[acyl-carrier-protein] hydrolase activity  palmitoyl-[acyl-carrier-protein] hydrolase activity  mammary gland development  phosphopantetheine binding  positive regulation of cellular metabolic process  long-chain fatty-acyl-CoA biosynthetic process  melanosome  glycogen granule  protein homodimerization activity  cadherin binding  enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity  3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity  oxidation-reduction process  extracellular exosome  NADPH binding  cellular response to interleukin-4  3-oxo-glutaryl-[acp] methyl ester reductase activity  3-oxo-pimeloyl-[acp] methyl ester reductase activity  
Pathways : KEGGFatty acid biosynthesis    Insulin signaling pathway   
NDEx NetworkFASN
Atlas of Cancer Signalling NetworkFASN
Wikipedia pathwaysFASN
Orthology - Evolution
OrthoDB2194
GeneTree (enSembl)ENSG00000169710
Phylogenetic Trees/Animal Genes : TreeFamFASN
HOVERGENP49327
HOGENOMP49327
Homologs : HomoloGeneFASN
Homology/Alignments : Family Browser (UCSC)FASN
Gene fusions - Rearrangements
Fusion : MitelmanFASN/CCDC57 [17q25.3/17q25.3]  
Fusion : MitelmanFASN/ZNF595 [17q25.3/4p16.3]  [t(4;17)(p16;q25)]  
Fusion: TCGAFASN 17q25.3 CCDC57 17q25.3 OV
Fusion: TCGAFASN 17q25.3 ZNF595 4p16.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFASN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FASN
dbVarFASN
ClinVarFASN
1000_GenomesFASN 
Exome Variant ServerFASN
ExAC (Exome Aggregation Consortium)FASN (select the gene name)
Genetic variants : HAPMAP2194
Genomic Variants (DGV)FASN [DGVbeta]
DECIPHERFASN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFASN 
Mutations
ICGC Data PortalFASN 
TCGA Data PortalFASN 
Broad Tumor PortalFASN
OASIS PortalFASN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFASN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFASN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FASN
DgiDB (Drug Gene Interaction Database)FASN
DoCM (Curated mutations)FASN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FASN (select a term)
intoGenFASN
Cancer3DFASN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600212   
Orphanet
MedgenFASN
Genetic Testing Registry FASN
NextProtP49327 [Medical]
TSGene2194
GENETestsFASN
Target ValidationFASN
Huge Navigator FASN [HugePedia]
snp3D : Map Gene to Disease2194
BioCentury BCIQFASN
ClinGenFASN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2194
Chemical/Pharm GKB GenePA28006
Clinical trialFASN
Miscellaneous
canSAR (ICR)FASN (select the gene name)
Probes
Litterature
PubMed257 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFASN
EVEXFASN
GoPubMedFASN
iHOPFASN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:00:58 CEST 2017

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