FASTKD2 (FAST kinase domains 2)

2011-08-01  

Identity

HGNC
FASTKD2
LOCATION
2q33.3
LOCUSID
22868
ALIAS
COXPD44,KIAA0971
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22868
MIM: 612322
HGNC: 29160
Ensembl: ENSG00000118246

Variants:

dbSNP: 22868
ClinVar: 22868
TCGA: ENSG00000118246
COSMIC: FASTKD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118246ENST00000236980Q9NYY8
ENSG00000118246ENST00000236980A0A024R419
ENSG00000118246ENST00000402774Q9NYY8
ENSG00000118246ENST00000402774A0A024R419
ENSG00000118246ENST00000403094Q9NYY8
ENSG00000118246ENST00000403094A0A024R419
ENSG00000118246ENST00000418289C9JPI6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
263705832015FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation.28
187717612008FASTKD2 nonsense mutation in an infantile mitochondrial encephalomyopathy associated with cytochrome c oxidase deficiency.27
214447242011A novel transcription complex that selectively modulates apoptosis of breast cancer cells through regulation of FASTKD2.24
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
253853692015FASTKD2 is associated with memory and hippocampal structure in older adults.16
290363962017The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.10
254097622014Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain.4

Citation

Dessen P

FASTKD2 (FAST kinase domains 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52337/fastkd2