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FAT1 (FAT tumor suppressor homolog 1 (Drosophila))

Written2011-02Kunzang Chosdol, Bhawana Dikshit, Subrata Sinha
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India

(Note : for Links provided by Atlas : click)

Identity

Alias_namesFAT
FAT tumor suppressor (Drosophila) homolog
FAT tumor suppressor homolog 1 (Drosophila)
Alias_symbol (synonym)CDHF7
CDHR8
Other aliasME5
hFat1
HGNC (Hugo) FAT1
LocusID (NCBI) 2195
Atlas_Id 40533
Location 4q35.2  [Link to chromosome band 4q35]
Location_base_pair Starts at 186587783 and ends at 186723833 bp from pter ( according to hg19-Feb_2009)  [Mapping FAT1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAT1 (4q35.2) / ACSL1 (4q35.1)FAT1 (4q35.2) / CFAP97 (4q35.1)FAT1 (4q35.2) / FAT1 (4q35.2)
FAT1 (4q35.2) / SPARC (5q33.1)FBRSL1 (12q24.33) / FAT1 (4q35.2)STMN2 (8q21.13) / FAT1 (4q35.2)
Note FAT1 is an ortholog of the Drosophila tumor suppressor gene 'fat'. In Drosophila, it is essential for controlling cell proliferation during development. The gene product is a member of the cadherin superfamily, characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell-cell communication.

DNA/RNA

Description FAT1 gene is located on the chromosome 4q35.2 (Accession: NC_000004.11). The total length of the gene is 136050 bases (187509746 bp to 187630981 bp from pter) of reverse strand. There are 27 exons.
An alternate assembly suggested to be starting from 187745931 bp to 187881981 bp from pter.
Transcription The length of the transcript is 14773 bps made from 27 exons (Accession: NM_005245.3).
Pseudogene FAT tumor suppressor homolog 1 (Drosophila) pseudogene 1 (FAT1P1).
Other name: dJ697P8.1; sequence accession ID: AL050403; location chromosome: 20p12.2.

Protein

Note Known protein coding gene.

Protein names
Recommended name: protocadherin Fat 1.
Alternative names: Cadherin-related tumor suppressor homolog, Protein fat homolog, Cadherin family member 7.

Description 4588 aa (Accession: NP_005236.2).
Expression Expressed in epithelial, endothelial and smooth muscle cells.
Localisation Cell membrane; single-pass type I membrane protein.
Function Could function as a cell-adhesion molecule, cell signalling molecule, and have a role in cell migration.
Fat in Drosophila acts via SWH signalling pathway as tumour suppressor gene. Homolog of SWH pathway molecules are present in human, so there is a possibility of acting FAT1 as an upstream regulator of SWH pathway in human.
In human, FAT1 expression is highest at the embryonic stages and diminishes later in adult life. In human fetal tissues, high levels of FAT1 transcripts were found in kidney, lungs, and eye epithelia, and the expression was found to be down regulated in the corresponding adult tissues, indicating the role of FAT1 in organ development. FAT1 also has a role in cell migration (Moeller et al., 2004; Tanoue and Takeichi, 2004) and found to be up-regulated in migrating cells, also crucial for efficient wound healing (Braun et al., 2007).
In Drosophila, fat is an upstream regulator of the Salvador-Wart-Hippo (SWH) signaling pathway (Cho et al., 2006; Bennett and Harvey, 2006). The signalling molecules of SWH pathway are conserved in mammals (figure below) but the role of FAT1 as an apical regulator of SWH pathway in human has not yet been established.
 
  Salvador-Warts-Hippo pathway. Mammalian hippo signaling pathway shows homology with Drosophila pathway proteins (depicted in similar color and shape).
In Drosophila fat (ft) interacts with core kinase cascade via Expanded (Ex). The core kinase cascade includes kinase Hippo (hpo), adaptor proteins mats and Salvador (Sav) and kinase Warts. The core kinase cascade inhibits phosphorylation of transcriptional co-activator Yorkie (Yki) causing its translocation to nucleus where it binds to transcriptional activator Scalloped (Sd) and modulates gene expression.
In mammals, whether FAT1 is involved in hippo pathway regulation is not clear. The effector molecule, phospho-YAP, is reported to interact with p73 in the nucleus and promotes cell death. There is no p73 homolog known to be reported in Drosophila. YAP is also found to interact with other transcription factors and modulate gene expression, thus, the outcome of hippo pathway is context dependent.
Homology Paralogs for FAT1 gene: FAT2, FAT3, FAT4.
OrganismGeneLocusDescriptionSimilarity to human FAT1
Dog
(Canis familiaris)
FAT1Chr. 16FAT tumor suppressor homolog 1 (Drosophila)86.95(n), 91.17(a)
Pig
(Sus scrofa)
FAT1Chr. 17FAT tumor suppressor homolog 1 (Drosophila)86(n), 90(a)
Cow
(Bos Taurus)
FAT1Chr. 27FAT tumor suppressor homolog 1 (Drosophila)84.18(n) 89.93(a)
Rat
(Rattus norvegicus)
Fat1Chr. 16q11FAT tumor suppressor homolog 1 (Drosophila)82.93(n) 88.16(a)
Mouse
(Mus musculus)
Fat1Chr. 8
(25.00 cM)
FAT tumor suppressor homolog 1 (Drosophila)82.51(n) 88.14(a)
Chicken
(Gallus gallus)
FATChr. 4FAT tumor suppressor homolog 1 (Drosophila)76.35(n) 81.43(a)
Zebrafish
(Danio rerio)
fat1Chr. 1FAT tumor suppressor homolog 164.68(n) 64.82(a)
Fruit fly
(Drosophila melanogaster)
ft and fat2Chr. 2L (ft) Chr. 3L (fat2)fat and fat2ft - 42.8(n) 42(a),
fat2 - 47.99(n) 39.02(a)
Worm
(Caenorhabditis elegans)
cdh-4Chr. IIICadherin family44.19(n) 30.89(a)
African malaria mosquito
(Anopheles gambiae)
AgaP_AGAP011526Chr. 3LAGAP011526-PA48.06(n) 39.5(a)
Orthologs for FAT1 gene from other species.

Mutations

Note No known mutations. Single nucleotide polymorphism (SNPs): gene: FAT1 (ENSG00000083857).

Implicated in

Note
  
Entity Various cancers
Note FAT1, a member of the cadherin gene family, is homologue of Drosophila tumour suppressor gene fat. In Drosophila, fat gene is important in controlling cell proliferation during development and any defect in the expression of fat would lead to tumor development (Bryant et al., 1988). Dunne et al. (1995) have identified the human homologue and studied the tissue distribution of FAT transcripts in adult and fetal tissues.
Loss of heterozygosity and altered expression of FAT1 has been found in human glial tumors (Chosdol et al., 2009). Homozygous deletion of FAT1 gene was detected in oral cancer (Nakaya et al., 2007). Kwaepila et al. (2006) found higher FAT1 expression in more malignant form of breast cancer tissues by immunohistochemistry (IHC). There are studies showing LOH and/or deletion of the chromosome 4q34-35 region (which harbors FAT gene) in many tumors including gliomas. LOH was found in grade IV gliomas using microsatellite markers (Hu et al., 2002), though the gene itself has not been implicated. Other tumors like small cell lung carcinoma (Cho et al., 2002), hepatocellular carcinoma (Zhang et al., 2005; Chang et al., 2002) and cervical carcinoma (Backsch et al., 2005) etc showed alterations/LOH in the chromosomal 4q34-q35 locus and significant association of 4q34-q35 region with increased risk of progression of these tumors was suggested. Since the FAT gene is located in this region it may have an important role to play in the development and progression of these tumors.
  
  
Entity Astrocytic tumour
Note Loss of heterozygosity and altered expression of FAT1 in astrocytic tumors (Chosdol et al., 2009).
  
  
Entity Breast cancer
Note Increased FAT1 expression contributes to loss of duct formation, and increased cell migration and invasion in breast cancer (Kwaepila et al., 2006).
  
  
Entity Oral cancer
Note Homozygous deletion of FAT in the cell lines and in primary oral cancers was studied. Homozygous deletion hot spots were observed in exon 1 (9/20, 45%) and exon 4 (7/20, 35%). The methylation status of the FAT CpG island in squamous cell carcinomas correlated negatively with its expression. Mutations in FAT is suggested as an important factor in the development of oral cancer. Moreover, loss of gene expression was identified in other types of squamous cell carcinoma (Nakaya et al., 2007).
  
  
Entity Psychiatric disorders
Note Bipolar disorder: a positional cloning strategy, combined with association analysis have provided evidence that a cadherin gene, FAT, confers susceptibility to bipolar disorder (Blair et al., 2006).
  
  
Entity Cell migration
Note FAT1 is known to play role in cell migration. FAT1 knockdown decreases cell migration in vascular smooth muscle cells (Hou et al., 2006; Hou and Sibinga, 2009). FAT1 plays an integrative role in regulating cell migration by participating in Ena/VASP-dependent regulation of cytoskeletal dynamics (Moeller et al., 2004).
  

Bibliography

A region on human chromosome 4 (q35.1-->qter) induces senescence in cell hybrids and is involved in cervical carcinogenesis.
Backsch C, Rudolph B, Kuhne-Heid R, Kalscheuer V, Bartsch O, Jansen L, Beer K, Meyer B, Schneider A, Dust M.
Genes Chromosomes Cancer. 2005 Jul;43(3):260-72.
PMID 15838843
 
Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.
Bennett FC, Harvey KF.
Curr Biol. 2006 Nov 7;16(21):2101-10. Epub 2006 Oct 12.
PMID 17045801
 
Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele.
Blair IP, Chetcuti AF, Badenhop RF, Scimone A, Moses MJ, Adams LJ, Craddock N, Green E, Kirov G, Owen MJ, Kwok JB, Donald JA, Mitchell PB, Schofield PR.
Mol Psychiatry. 2006 Apr;11(4):372-83.
PMID 16402135
 
Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells.
Braun GS, Kretzler M, Heider T, Floege J, Holzman LB, Kriz W, Moeller MJ.
J Biol Chem. 2007 Aug 3;282(31):22823-33. Epub 2007 May 11.
PMID 17500054
 
Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila.
Bryant PJ, Huettner B, Held LI Jr, Ryerse J, Szidonya J.
Dev Biol. 1988 Oct;129(2):541-54.
PMID 3417051
 
Assessment of chromosomal losses and gains in hepatocellular carcinoma.
Chang J, Kim NG, Piao Z, Park C, Park KS, Paik YK, Lee WJ, Kim BR, Kim H.
Cancer Lett. 2002 Aug 28;182(2):193-202.
PMID 12048165
 
Delineation of a Fat tumor suppressor pathway.
Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD.
Nat Genet. 2006 Oct;38(10):1142-50. Epub 2006 Sep 17.
PMID 16980976
 
Identification of tumor suppressor loci on the long arm of chromosome 4 in primary small cell lung cancers.
Cho ES, Chang J, Chung KY, Shin DH, Kim YS, Kim SK, Kim SK.
Yonsei Med J. 2002 Apr;43(2):145-51.
PMID 11971207
 
Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors.
Chosdol K, Misra A, Puri S, Srivastava T, Chattopadhyay P, Sarkar C, Mahapatra AK, Sinha S.
BMC Cancer. 2009 Jan 7;9:5.
PMID 19126244
 
Cloning and expression throughout mouse development of mfat1, a homologue of the Drosophila tumour suppressor gene fat.
Cox B, Hadjantonakis AK, Collins JE, Magee AI.
Dev Dyn. 2000 Mar;217(3):233-40.
PMID 10741417
 
Cloning and expression of the large zebrafish protocadherin gene, Fat.
Down M, Power M, Smith SI, Ralston K, Spanevello M, Burns GF, Boyd AW.
Gene Expr Patterns. 2005 Apr;5(4):483-90.
PMID 15749076
 
Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule.
Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q, Beverley PC, Owen MJ.
Genomics. 1995 Nov 20;30(2):207-23.
PMID 8586420
 
The Fat1 cadherin integrates vascular smooth muscle cell growth and migration signals.
Hou R, Liu L, Anees S, Hiroyasu S, Sibinga NE
J Cell Biol. 2006 May 8;173(3):417-29.
PMID 16682528
 
Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.
Hou R, Sibinga NE.
J Biol Chem. 2009 Mar 13;284(11):6955-65. Epub 2009 Jan 7.
PMID 19131340
 
Chromosome 14q may harbor multiple tumor suppressor genes in primary glioblastoma multiforme.
Hu J, Jiang C, Ng HK, Pang JC, Tong CY.
Chin Med J (Engl). 2002 Aug;115(8):1201-4.
PMID 12215292
 
Comparative integromics on FAT1, FAT2, FAT3 and FAT4.
Katoh Y, Katoh M.
Int J Mol Med. 2006 Sep;18(3):523-8.
PMID 16865240
 
Immunohistological localisation of human FAT1 (hFAT) protein in 326 breast cancers. Does this adhesion molecule have a role in pathogenesis?
Kwaepila N, Burns G, Leong AS.
Pathology. 2006 Apr;38(2):125-31.
PMID 16581652
 
Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus.
Magg T, Schreiner D, Solis GP, Bade EG, Hofer HW.
Exp Cell Res. 2005 Jul 1;307(1):100-8. Epub 2005 Apr 15.
PMID 15922730
 
Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.
Moeller MJ, Soofi A, Braun GS, Li X, Watzl C, Kriz W, Holzman LB.
EMBO J. 2004 Oct 1;23(19):3769-79. Epub 2004 Sep 2.
PMID 15343270
 
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Nakaya K, Yamagata HD, Arita N, Nakashiro KI, Nose M, Miki T, Hamakawa H.
Oncogene. 2007 Aug 9;26(36):5300-8. Epub 2007 Feb 26.
PMID 17325662
 
Expression of the rat homologue of the Drosophila fat tumour suppressor gene.
Ponassi M, Jacques TS, Ciani L, ffrench Constant C.
Mech Dev. 1999 Feb;80(2):207-12.
PMID 10072790
 
The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins.
Schreiner D, Muller K, Hofer HW.
FEBS Lett. 2006 Oct 2;580(22):5295-300. Epub 2006 Sep 12.
PMID 16979624
 
Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.
Tanoue T, Takeichi M.
J Cell Biol. 2004 May 24;165(4):517-28. Epub 2004 May 17.
PMID 15148305
 
Clinicopathological significance of loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in China.
Zhang SH, Cong WM, Xian ZH, Wu MC.
World J Gastroenterol. 2005 May 28;11(20):3034-9.
PMID 15918185
 

Citation

This paper should be referenced as such :
Chosdol, K ; Dikshit, B ; Sinha, S
FAT1 (FAT tumor suppressor homolog 1 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2011;15(9):717-720.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/FAT1ID40533ch4q35.html


External links

|TD>FAT1
Nomenclature
HGNC (Hugo)FAT1   3595
Cards
AtlasFAT1ID40533ch4q35
Entrez_Gene (NCBI)FAT1  2195  FAT atypical cadherin 1
AliasesCDHF7; CDHR8; FAT; ME5; 
hFat1
GeneCards (Weizmann)FAT1
Ensembl hg19 (Hinxton)ENSG00000083857 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083857 [Gene_View]  chr4:186587783-186723833 [Contig_View]  FAT1 [Vega]
ICGC DataPortalENSG00000083857
TCGA cBioPortalFAT1
AceView (NCBI)FAT1
Genatlas (Paris)FAT1
WikiGenes2195
SOURCE (Princeton)FAT1
Genetics Home Reference (NIH)FAT1
Genomic and cartography
GoldenPath hg38 (UCSC)FAT1  -     chr4:186587783-186723833 -  4q35.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FAT1  -     4q35.2   [Description]    (hg19-Feb_2009)
EnsemblFAT1 - 4q35.2 [CytoView hg19]  FAT1 - 4q35.2 [CytoView hg38]
Mapping of homologs : NCBIFAT1 [Mapview hg19]  FAT1 [Mapview hg38]
OMIM600976   
Gene and transcription
Genbank (Entrez)AK307938 BC012432 BF327563 BP363658 BU729008
RefSeq transcript (Entrez)NM_005245
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FAT1
Cluster EST : UnigeneHs.481371 [ NCBI ]
CGAP (NCI)Hs.481371
Alternative Splicing GalleryENSG00000083857
Gene ExpressionFAT1 [ NCBI-GEO ]   FAT1 [ EBI - ARRAY_EXPRESS ]   FAT1 [ SEEK ]   FAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2195
GTEX Portal (Tissue expression)FAT1
Human Protein AtlasENSG00000083857-FAT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14517   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14517  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14517
Splice isoforms : SwissVarQ14517
PhosPhoSitePlusQ14517
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    CADHERIN_1 (PS00232)    CADHERIN_2 (PS50268)    EGF_1 (PS00022)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    LAM_G_DOMAIN (PS50025)   
Domains : Interpro (EBI)Cadherin    Cadherin-like    Cadherin_CS    ConA-like_dom    EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Laminin_G   
Domain families : Pfam (Sanger)Cadherin (PF00028)    EGF (PF00008)    Laminin_G_2 (PF02210)   
Domain families : Pfam (NCBI)pfam00028    pfam00008    pfam02210   
Domain families : Smart (EMBL)CA (SM00112)  EGF (SM00181)  EGF_CA (SM00179)  LamG (SM00282)  
Conserved Domain (NCBI)FAT1
DMDM Disease mutations2195
Blocks (Seattle)FAT1
SuperfamilyQ14517
Human Protein Atlas [tissue]ENSG00000083857-FAT1 [tissue]
Peptide AtlasQ14517
HPRD02986
IPIIPI00940698   IPI00031411   IPI00965298   IPI00965795   IPI00967013   IPI00966710   IPI00964991   
Protein Interaction databases
DIP (DOE-UCLA)Q14517
IntAct (EBI)Q14517
FunCoupENSG00000083857
BioGRIDFAT1
STRING (EMBL)FAT1
ZODIACFAT1
Ontologies - Pathways
QuickGOQ14517
Ontology : AmiGOcalcium ion binding  protein binding  nucleus  plasma membrane  integral component of plasma membrane  cell-cell junction  focal adhesion  actin filament organization  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  establishment or maintenance of cell polarity  cell-cell signaling  anatomical structure morphogenesis  single organismal cell-cell adhesion  cell migration  lamellipodium  filopodium  perinuclear region of cytoplasm  extracellular exosome  
Ontology : EGO-EBIcalcium ion binding  protein binding  nucleus  plasma membrane  integral component of plasma membrane  cell-cell junction  focal adhesion  actin filament organization  cell adhesion  homophilic cell adhesion via plasma membrane adhesion molecules  establishment or maintenance of cell polarity  cell-cell signaling  anatomical structure morphogenesis  single organismal cell-cell adhesion  cell migration  lamellipodium  filopodium  perinuclear region of cytoplasm  extracellular exosome  
NDEx NetworkFAT1
Atlas of Cancer Signalling NetworkFAT1
Wikipedia pathwaysFAT1
Orthology - Evolution
OrthoDB2195
GeneTree (enSembl)ENSG00000083857
Phylogenetic Trees/Animal Genes : TreeFamFAT1
HOVERGENQ14517
HOGENOMQ14517
Homologs : HomoloGeneFAT1
Homology/Alignments : Family Browser (UCSC)FAT1
Gene fusions - Rearrangements
Fusion : MitelmanFAT1/ACSL1 [4q35.2/4q35.1]  
Fusion : MitelmanFAT1/CFAP97 [4q35.2/4q35.1]  [t(4;4)(q35;q35)]  
Fusion: TCGA_MDACCFAT1 4q35.2 ACSL1 4q35.1 HNSC
Fusion: TCGA_MDACCFAT1 4q35.2 KIAA1430 HNSC
Tumor Fusion PortalFAT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FAT1
dbVarFAT1
ClinVarFAT1
1000_GenomesFAT1 
Exome Variant ServerFAT1
ExAC (Exome Aggregation Consortium)ENSG00000083857
GNOMAD BrowserENSG00000083857
Genetic variants : HAPMAP2195
Genomic Variants (DGV)FAT1 [DGVbeta]
DECIPHERFAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFAT1 
Mutations
ICGC Data PortalFAT1 
TCGA Data PortalFAT1 
Broad Tumor PortalFAT1
OASIS PortalFAT1 [ Somatic mutations - Copy number]
Cancer Gene: CensusFAT1 
Somatic Mutations in Cancer : COSMICFAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFAT1
intOGen PortalFAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FAT1
DgiDB (Drug Gene Interaction Database)
DoCM (Curated mutations)FAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FAT1 (select a term)
intoGenFAT1
NCG5 (London)FAT1
Cancer3DFAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600976   
Orphanet
DisGeNETFAT1
MedgenFAT1
Genetic Testing Registry FAT1
NextProtQ14517 [Medical]
TSGene2195
GENETestsFAT1
Target ValidationFAT1
Huge Navigator FAT1 [HugePedia]
snp3D : Map Gene to Disease2195
BioCentury BCIQFAT1
ClinGenFAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2195
Chemical/Pharm GKB GenePA164719952
Clinical trialFAT1
Miscellaneous
canSAR (ICR)FAT1 (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=FAT1
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFAT1
EVEXFAT1
GoPubMedFAT1
iHOPFAT1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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