Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBH1 (F-box DNA helicase 1)

Identity

Other aliasFBXO18
Fbx18
hFBH1
HGNC (Hugo) FBH1
LocusID (NCBI) 84893
Atlas_Id 57326
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 5890203 and ends at 5937595 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)FBH1   13620
Cards
Entrez_Gene (NCBI)FBH1  84893  F-box DNA helicase 1
AliasesFBXO18; Fbx18; hFBH1
GeneCards (Weizmann)FBH1
Ensembl hg19 (Hinxton)ENSG00000134452 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134452 [Gene_View]  ENSG00000134452 [Sequence]  chr10:5890203-5937595 [Contig_View]  FBH1 [Vega]
ICGC DataPortalENSG00000134452
TCGA cBioPortalFBH1
AceView (NCBI)FBH1
Genatlas (Paris)FBH1
WikiGenes84893
SOURCE (Princeton)FBH1
Genetics Home Reference (NIH)FBH1
Genomic and cartography
GoldenPath hg38 (UCSC)FBH1  -     chr10:5890203-5937595 +  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBH1  -     10p15.1   [Description]    (hg19-Feb_2009)
EnsemblFBH1 - 10p15.1 [CytoView hg19]  FBH1 - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIFBH1 [Mapview hg19]  FBH1 [Mapview hg38]
OMIM607222   
Gene and transcription
Genbank (Entrez)AF380349 AF454502 AF456237 AI818794 AK027381
RefSeq transcript (Entrez)NM_001258452 NM_001258453 NM_032807 NM_178150
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBH1
Cluster EST : UnigeneHs.498543 [ NCBI ]
CGAP (NCI)Hs.498543
Alternative Splicing GalleryENSG00000134452
Gene ExpressionFBH1 [ NCBI-GEO ]   FBH1 [ EBI - ARRAY_EXPRESS ]   FBH1 [ SEEK ]   FBH1 [ MEM ]
Gene Expression Viewer (FireBrowse)FBH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84893
GTEX Portal (Tissue expression)FBH1
Human Protein AtlasENSG00000134452-FBH1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ0
Splice isoforms : SwissVarQ8NFZ0
PhosPhoSitePlusQ8NFZ0
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)DNA_helicase_UvrD-like_C    DNA_helicase_UvrD/REP    F-box-like_dom_sf    F-box_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)F-box-like (PF12937)    UvrD_C (PF13361)   
Domain families : Pfam (NCBI)pfam12937    pfam13361   
Conserved Domain (NCBI)FBH1
DMDM Disease mutations84893
Blocks (Seattle)FBH1
SuperfamilyQ8NFZ0
Human Protein Atlas [tissue]ENSG00000134452-FBH1 [tissue]
Peptide AtlasQ8NFZ0
IPIIPI00409721   IPI00375254   IPI00873232   IPI00641813   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ0
IntAct (EBI)Q8NFZ0
FunCoupENSG00000134452
BioGRIDFBH1
STRING (EMBL)FBH1
ZODIACFBH1
Ontologies - Pathways
QuickGOQ8NFZ0
Ontology : AmiGOdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  chromatin  positive regulation of protein phosphorylation  DNA helicase activity  DNA helicase activity  double-stranded DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  cellular response to DNA damage stimulus  cell death  cell death  cell death  DNA translocase activity  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  replication fork processing  replication fork processing  DNA duplex unwinding  negative regulation of chromatin binding  3'-5' DNA helicase activity  ATP-dependent 3'-5' DNA helicase activity  nuclear SCF ubiquitin ligase complex  replication fork protection  replication fork protection  response to intra-S DNA damage checkpoint signaling  response to intra-S DNA damage checkpoint signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of double-strand break repair via homologous recombination  negative regulation of double-strand break repair via homologous recombination  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  double-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  chromatin  positive regulation of protein phosphorylation  DNA helicase activity  DNA helicase activity  double-stranded DNA binding  single-stranded DNA binding  single-stranded DNA binding  protein binding  ATP binding  nucleus  nucleus  cellular response to DNA damage stimulus  cell death  cell death  cell death  DNA translocase activity  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  replication fork processing  replication fork processing  DNA duplex unwinding  negative regulation of chromatin binding  3'-5' DNA helicase activity  ATP-dependent 3'-5' DNA helicase activity  nuclear SCF ubiquitin ligase complex  replication fork protection  replication fork protection  response to intra-S DNA damage checkpoint signaling  response to intra-S DNA damage checkpoint signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of double-strand break repair via homologous recombination  negative regulation of double-strand break repair via homologous recombination  
NDEx NetworkFBH1
Atlas of Cancer Signalling NetworkFBH1
Wikipedia pathwaysFBH1
Orthology - Evolution
OrthoDB84893
GeneTree (enSembl)ENSG00000134452
Phylogenetic Trees/Animal Genes : TreeFamFBH1
HOVERGENQ8NFZ0
HOGENOMQ8NFZ0
Homologs : HomoloGeneFBH1
Homology/Alignments : Family Browser (UCSC)FBH1
Gene fusions - Rearrangements
Fusion : QuiverFBH1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBH1
dbVarFBH1
ClinVarFBH1
1000_GenomesFBH1 
Exome Variant ServerFBH1
ExAC (Exome Aggregation Consortium)ENSG00000134452
GNOMAD BrowserENSG00000134452
Varsome BrowserFBH1
Genetic variants : HAPMAP84893
Genomic Variants (DGV)FBH1 [DGVbeta]
DECIPHERFBH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBH1 
Mutations
ICGC Data PortalFBH1 
TCGA Data PortalFBH1 
Broad Tumor PortalFBH1
OASIS PortalFBH1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDFBH1
BioMutasearch FBH1
DgiDB (Drug Gene Interaction Database)FBH1
DoCM (Curated mutations)FBH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBH1 (select a term)
intoGenFBH1
Cancer3DFBH1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607222   
Orphanet
DisGeNETFBH1
MedgenFBH1
Genetic Testing Registry FBH1
NextProtQ8NFZ0 [Medical]
TSGene84893
GENETestsFBH1
Target ValidationFBH1
Huge Navigator FBH1 [HugePedia]
snp3D : Map Gene to Disease84893
BioCentury BCIQFBH1
ClinGenFBH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84893
Chemical/Pharm GKB GenePA134948258
Clinical trialFBH1
Miscellaneous
canSAR (ICR)FBH1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBH1
EVEXFBH1
GoPubMedFBH1
iHOPFBH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:05:57 CET 2018

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