FBH1 (F-box DNA helicase 1)

2018-02-01  

Identity

HGNC
LOCATION
10p15.1
LOCUSID
ALIAS
FBXO18,Fbx18,hFBH1

Other Information

Locus ID:

NCBI: 84893
MIM: 607222
HGNC: 13620
Ensembl: ENSG00000134452

Variants:

dbSNP: 84893
ClinVar: 84893
TCGA: ENSG00000134452
COSMIC: FBH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134452ENST00000362091Q8NFZ0
ENSG00000134452ENST00000379999Q8NFZ0
ENSG00000134452ENST00000397269F6UZG9

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
197363162009Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities.49
177240852007The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles.35
233610132013FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.35
119562082002The novel human DNA helicase hFBH1 is an F-box protein.34
241081242013FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.33
236776132013The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.31
233196002013FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress.24
294674152018PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.24
255855782015FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.17

Citation

Dessen P

FBH1 (F-box DNA helicase 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57326/fbh1