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FBL (fibrillarin)

Identity

Alias_symbol (synonym)RNU3IP1
FLRN
FIB
Other alias
HGNC (Hugo) FBL
LocusID (NCBI) 2091
Atlas_Id 40539
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39834453 and ends at 39846414 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C16orf58 (16p11.2) / FBL (19q13.2)CNBP (3q21.3) / FBL (19q13.2)FBL (19q13.2) / HLA-E (6p21.33)
FBL (19q13.2) / RASGRP4 (19q13.2)FBL (19q13.2) / RYR1 (19q13.2)FTH1 (11q12.3) / FBL (19q13.2)
RPS16 (19q13.2) / FBL (19q13.2)FBL 19q13.2 / RASGRP4 19q13.2FBL 19q13.2 / RYR1 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBL   3599
Cards
Entrez_Gene (NCBI)FBL  2091  fibrillarin
AliasesFIB; FLRN; RNU3IP1
GeneCards (Weizmann)FBL
Ensembl hg19 (Hinxton)ENSG00000105202 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105202 [Gene_View]  chr19:39834453-39846414 [Contig_View]  FBL [Vega]
ICGC DataPortalENSG00000105202
TCGA cBioPortalFBL
AceView (NCBI)FBL
Genatlas (Paris)FBL
WikiGenes2091
SOURCE (Princeton)FBL
Genetics Home Reference (NIH)FBL
Genomic and cartography
GoldenPath hg38 (UCSC)FBL  -     chr19:39834453-39846414 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBL  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblFBL - 19q13.2 [CytoView hg19]  FBL - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIFBL [Mapview hg19]  FBL [Mapview hg38]
OMIM134795   
Gene and transcription
Genbank (Entrez)AB451384 AI085380 AK296950 AK308649 BC015218
RefSeq transcript (Entrez)NM_001436
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBL
Cluster EST : UnigeneHs.299002 [ NCBI ]
CGAP (NCI)Hs.299002
Alternative Splicing GalleryENSG00000105202
Gene ExpressionFBL [ NCBI-GEO ]   FBL [ EBI - ARRAY_EXPRESS ]   FBL [ SEEK ]   FBL [ MEM ]
Gene Expression Viewer (FireBrowse)FBL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2091
GTEX Portal (Tissue expression)FBL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22087   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22087  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22087
Splice isoforms : SwissVarP22087
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusP22087
Domaine pattern : Prosite (Expaxy)FIBRILLARIN (PS00566)   
Domains : Interpro (EBI)Fibrillarin    Fibrillarin_CS    SAM-dependent_MTases   
Domain families : Pfam (Sanger)Fibrillarin (PF01269)   
Domain families : Pfam (NCBI)pfam01269   
Domain families : Smart (EMBL)Fibrillarin (SM01206)  
Conserved Domain (NCBI)FBL
DMDM Disease mutations2091
Blocks (Seattle)FBL
PDB (SRS)2IPX   
PDB (PDBSum)2IPX   
PDB (IMB)2IPX   
PDB (RSDB)2IPX   
Structural Biology KnowledgeBase2IPX   
SCOP (Structural Classification of Proteins)2IPX   
CATH (Classification of proteins structures)2IPX   
SuperfamilyP22087
Human Protein AtlasENSG00000105202
Peptide AtlasP22087
HPRD00617
IPIIPI00025039   
Protein Interaction databases
DIP (DOE-UCLA)P22087
IntAct (EBI)P22087
FunCoupENSG00000105202
BioGRIDFBL
STRING (EMBL)FBL
ZODIACFBL
Ontologies - Pathways
QuickGOP22087
Ontology : AmiGObox C/D snoRNA 3'-end processing  TFIID-class transcription factor binding  osteoblast differentiation  fibrillar center  dense fibrillar component  granular component  RNA binding  protein binding  nucleus  nucleoplasm  chromosome  nucleolus  rRNA processing  tRNA processing  rRNA methyltransferase activity  Cajal body  membrane  rRNA methylation  box C/D snoRNP complex  box C/D snoRNP complex  small-subunit processome  snoRNA localization  ATPase binding  extracellular exosome  histone glutamine methylation  histone-glutamine methyltransferase activity  
Ontology : EGO-EBIbox C/D snoRNA 3'-end processing  TFIID-class transcription factor binding  osteoblast differentiation  fibrillar center  dense fibrillar component  granular component  RNA binding  protein binding  nucleus  nucleoplasm  chromosome  nucleolus  rRNA processing  tRNA processing  rRNA methyltransferase activity  Cajal body  membrane  rRNA methylation  box C/D snoRNP complex  box C/D snoRNP complex  small-subunit processome  snoRNA localization  ATPase binding  extracellular exosome  histone glutamine methylation  histone-glutamine methyltransferase activity  
Pathways : BIOCARTASARS Coronavirus Protease [Genes]   
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkFBL
Atlas of Cancer Signalling NetworkFBL
Wikipedia pathwaysFBL
Orthology - Evolution
OrthoDB2091
GeneTree (enSembl)ENSG00000105202
Phylogenetic Trees/Animal Genes : TreeFamFBL
HOVERGENP22087
HOGENOMP22087
Homologs : HomoloGeneFBL
Homology/Alignments : Family Browser (UCSC)FBL
Gene fusions - Rearrangements
Fusion : MitelmanFBL/RASGRP4 [19q13.2/19q13.2]  
Fusion : MitelmanFBL/RYR1 [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion: TCGAFBL 19q13.2 RASGRP4 19q13.2 SKCM
Fusion: TCGAFBL 19q13.2 RYR1 19q13.2 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBL
dbVarFBL
ClinVarFBL
1000_GenomesFBL 
Exome Variant ServerFBL
ExAC (Exome Aggregation Consortium)FBL (select the gene name)
Genetic variants : HAPMAP2091
Genomic Variants (DGV)FBL [DGVbeta]
DECIPHERFBL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBL 
Mutations
ICGC Data PortalFBL 
TCGA Data PortalFBL 
Broad Tumor PortalFBL
OASIS PortalFBL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBL
DgiDB (Drug Gene Interaction Database)FBL
DoCM (Curated mutations)FBL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBL (select a term)
intoGenFBL
Cancer3DFBL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134795   
Orphanet
MedgenFBL
Genetic Testing Registry FBL
NextProtP22087 [Medical]
TSGene2091
GENETestsFBL
Target ValidationFBL
Huge Navigator FBL [HugePedia]
snp3D : Map Gene to Disease2091
BioCentury BCIQFBL
ClinGenFBL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2091
Chemical/Pharm GKB GenePA28012
Clinical trialFBL
Miscellaneous
canSAR (ICR)FBL (select the gene name)
Probes
Litterature
PubMed106 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBL
EVEXFBL
GoPubMedFBL
iHOPFBL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:30 CEST 2017

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