FBL (fibrillarin)

2003-11-01 Affiliation

Identity

HGNC

FBL

LOCATION

19q13.2

LOCUSID

2091

ALIAS

FIB,FLRN,Nop1,RNU3IP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2091
MIM: 134795
HGNC: 3599
Ensembl: ENSG00000105202

Variants:

dbSNP: 2091
ClinVar: 2091
TCGA: ENSG00000105202
COSMIC: FBL

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000105202	ENST00000221801	P22087
ENSG00000105202	ENST00000594309	M0R2B0
ENSG00000105202	ENST00000594443	M0QXC9
ENSG00000105202	ENST00000595545	M0R299
ENSG00000105202	ENST00000597224	M0QXL5
ENSG00000105202	ENST00000597634	M0R0P1
ENSG00000105202	ENST00000598417	M0R1H0
ENSG00000105202	ENST00000599134	M0R2U2
ENSG00000105202	ENST00000601274	M0R2Q4

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ribosome biogenesis in eukaryotes	KEGG	ko03008
Ribosome biogenesis in eukaryotes	KEGG	hsa03008
Gene Expression	REACTOME	R-HSA-74160
rRNA processing	REACTOME	R-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosol	REACTOME	R-HSA-6791226
rRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6790901
rRNA processing in the nucleus and cytosol	REACTOME	R-HSA-8868773

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
24029231	2013	p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.	80
22909121	2012	Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.	26
17603021	2007	Fibrillarin, a nucleolar protein, is required for normal nuclear morphology and cellular growth in HeLa cells.	19
21536856	2011	Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.	15
27682166	2016	Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.	12
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
18292223	2008	Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin.	9
19331828	2009	Fibrillarin and Nop56 interact before being co-assembled in box C/D snoRNPs.	9
30540930	2018	SIRT7-Dependent Deacetylation of Fibrillarin Controls Histone H2A Methylation and rRNA Synthesis during the Cell Cycle.	7

Citation

Dessen P

FBL (fibrillarin)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40539/fbl