| Nomenclature |
|---|
| HGNC (Hugo) | FBP1 3606 |
| Cards |
|---|
| Entrez_Gene (NCBI) | FBP1 2203 fructose-bisphosphatase 1 |
| Aliases | FBP |
| GeneCards (Weizmann) | FBP1 |
| Ensembl hg19 (Hinxton) | ENSG00000165140 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000165140 [Gene_View] chr9:94603139-94640249 [Contig_View] FBP1 [Vega] |
| ICGC DataPortal | ENSG00000165140 |
| TCGA cBioPortal | FBP1 |
| AceView (NCBI) | FBP1 |
| Genatlas (Paris) | FBP1 |
| WikiGenes | 2203 |
| SOURCE (Princeton) | FBP1 |
| Genetics Home Reference (NIH) | FBP1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | FBP1 - chr9:94603139-94640249 - 9q22.32 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | FBP1 - 9q22.32 [Description] (hg19-Feb_2009) |
| Ensembl | FBP1 - 9q22.32 [CytoView hg19] FBP1 - 9q22.32 [CytoView hg38] |
| Mapping of homologs : NCBI | FBP1 [Mapview hg19] FBP1 [Mapview hg38] |
| OMIM | 229700 611570 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF073475 AK223395 AK292199 AK316583 AY544122 |
| RefSeq transcript (Entrez) | NM_000507 NM_001127628 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | FBP1 |
| Cluster EST : Unigene | Hs.494496 [ NCBI ] |
| CGAP (NCI) | Hs.494496 |
| Alternative Splicing Gallery | ENSG00000165140 |
| Gene Expression | FBP1 [ NCBI-GEO ] FBP1 [ EBI - ARRAY_EXPRESS ]
FBP1 [ SEEK ] FBP1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | FBP1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2203 |
| GTEX Portal (Tissue expression) | FBP1 |
| Human Protein Atlas | ENSG00000165140-FBP1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P09467 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P09467 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P09467 |
| Splice isoforms : SwissVar | P09467 |
| Catalytic activity : Enzyme | 3.1.3.11 [ Enzyme-Expasy ] 3.1.3.113.1.3.11 [ IntEnz-EBI ] 3.1.3.11 [ BRENDA ] 3.1.3.11 [ KEGG ] |
| PhosPhoSitePlus | P09467 |
| Domaine pattern : Prosite (Expaxy) | FBPASE (PS00124) |
| Domains : Interpro (EBI) | FBPase_class-1 FBPase_N FBPtase Fructose_bisphosphatase_AS |
| Domain families : Pfam (Sanger) | FBPase (PF00316) |
| Domain families : Pfam (NCBI) | pfam00316 |
| Conserved Domain (NCBI) | FBP1 |
| DMDM Disease mutations | 2203 |
| Blocks (Seattle) | FBP1 |
| PDB (SRS) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| PDB (PDBSum) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| PDB (IMB) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| PDB (RSDB) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| Structural Biology KnowledgeBase | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| SCOP (Structural Classification of Proteins) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| CATH (Classification of proteins structures) | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ |
| Superfamily | P09467 |
| Human Protein Atlas [tissue] | ENSG00000165140-FBP1 [tissue] |
| Peptide Atlas | P09467 |
| HPRD | 01973 |
| IPI | IPI00073772 IPI00644994 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P09467 |
| IntAct (EBI) | P09467 |
| FunCoup | ENSG00000165140 |
| BioGRID | FBP1 |
| STRING (EMBL) | FBP1 |
| ZODIAC | FBP1 |
| Ontologies - Pathways |
|---|
| QuickGO | P09467 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II transcriptional repressor activity, RNA polymerase II transcription factor binding protein binding nucleus cytoplasm cytosol cytosol cytosol sucrose biosynthetic process fructose metabolic process fructose 6-phosphate metabolic process gluconeogenesis gluconeogenesis gluconeogenesis gluconeogenesis regulation of gluconeogenesis AMP binding dephosphorylation dephosphorylation negative regulation of cell growth fructose 1,6-bisphosphate metabolic process cellular response to drug fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity identical protein binding negative regulation of glycolytic process negative regulation of glycolytic process negative regulation of Ras protein signal transduction metal ion binding monosaccharide binding protein homotetramerization extracellular exosome cellular response to magnesium ion |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II transcriptional repressor activity, RNA polymerase II transcription factor binding protein binding nucleus cytoplasm cytosol cytosol cytosol sucrose biosynthetic process fructose metabolic process fructose 6-phosphate metabolic process gluconeogenesis gluconeogenesis gluconeogenesis gluconeogenesis regulation of gluconeogenesis AMP binding dephosphorylation dephosphorylation negative regulation of cell growth fructose 1,6-bisphosphate metabolic process cellular response to drug fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity identical protein binding negative regulation of glycolytic process negative regulation of glycolytic process negative regulation of Ras protein signal transduction metal ion binding monosaccharide binding protein homotetramerization extracellular exosome cellular response to magnesium ion |
| Pathways : KEGG | Fructose and mannose metabolism Pentose phosphate pathway Insulin signaling pathway Glycolysis / Gluconeogenesis Carbon fixation |
| NDEx Network | FBP1 |
| Atlas of Cancer Signalling Network | FBP1 |
| Wikipedia pathways | FBP1 |
| Orthology - Evolution |
|---|
| OrthoDB | 2203 |
| GeneTree (enSembl) | ENSG00000165140 |
| Phylogenetic Trees/Animal Genes : TreeFam | FBP1 |
| HOVERGEN | P09467 |
| HOGENOM | P09467 |
| Homologs : HomoloGene | FBP1 |
| Homology/Alignments : Family Browser (UCSC) | FBP1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | FBP1 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | FBP1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | FBP1 |
| dbVar | FBP1 |
| ClinVar | FBP1 |
| 1000_Genomes | FBP1 |
| Exome Variant Server | FBP1 |
| ExAC (Exome Aggregation Consortium) | ENSG00000165140 |
| GNOMAD Browser | ENSG00000165140 |
| Genetic variants : HAPMAP | 2203 |
| Genomic Variants (DGV) | FBP1 [DGVbeta] |
| DECIPHER | FBP1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | FBP1 |
| Mutations |
|---|
| ICGC Data Portal | FBP1 |
| TCGA Data Portal | FBP1 |
| Broad Tumor Portal | FBP1 |
| OASIS Portal | FBP1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | FBP1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | FBP1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | MSeqDR-LSDB Mitochondrial Disease Locus Specific Database |
| BioMuta | search FBP1 |
| DgiDB (Drug Gene Interaction Database) | FBP1 |
| DoCM (Curated mutations) | FBP1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | FBP1 (select a term) |
| intoGen | FBP1 |
| Cancer3D | FBP1(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 229700 611570 |
| Orphanet | 676 |
| DisGeNET | FBP1 |
| Medgen | FBP1 |
| Genetic Testing Registry | FBP1
|
| NextProt | P09467 [Medical] |
| TSGene | 2203 |
| GENETests | FBP1 |
| Target Validation | FBP1 |
| Huge Navigator |
FBP1 [HugePedia] |
| snp3D : Map Gene to Disease | 2203 |
| BioCentury BCIQ | FBP1 |
| ClinGen | FBP1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2203 |
| Chemical/Pharm GKB Gene | PA28018 |
| Clinical trial | FBP1 |
| Miscellaneous |
|---|
| canSAR (ICR) | FBP1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 77 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | FBP1 |
| EVEX | FBP1 |
| GoPubMed | FBP1 |
| iHOP | FBP1 |
