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FBXL14 (F-box and leucine rich repeat protein 14)

Identity

Alias_symbol (synonym)MGC40195
Fbl14
Other alias
HGNC (Hugo) FBXL14
LocusID (NCBI) 144699
Atlas_Id 54313
Location 12p13.33  [Link to chromosome band 12p13]
Location_base_pair Starts at 1565993 and ends at 1594165 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANO2 (12p13.31) / FBXL14 (12p13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)FBXL14   28624
Cards
Entrez_Gene (NCBI)FBXL14  144699  F-box and leucine rich repeat protein 14
AliasesFbl14
GeneCards (Weizmann)FBXL14
Ensembl hg19 (Hinxton)ENSG00000171823 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171823 [Gene_View]  chr12:1565993-1594165 [Contig_View]  FBXL14 [Vega]
ICGC DataPortalENSG00000171823
TCGA cBioPortalFBXL14
AceView (NCBI)FBXL14
Genatlas (Paris)FBXL14
WikiGenes144699
SOURCE (Princeton)FBXL14
Genetics Home Reference (NIH)FBXL14
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL14  -     chr12:1565993-1594165 -  12p13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL14  -     12p13.33   [Description]    (hg19-Feb_2009)
EnsemblFBXL14 - 12p13.33 [CytoView hg19]  FBXL14 - 12p13.33 [CytoView hg38]
Mapping of homologs : NCBIFBXL14 [Mapview hg19]  FBXL14 [Mapview hg38]
OMIM609081   
Gene and transcription
Genbank (Entrez)BC028132 HQ447289
RefSeq transcript (Entrez)NM_152441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL14
Cluster EST : UnigeneHs.367956 [ NCBI ]
CGAP (NCI)Hs.367956
Alternative Splicing GalleryENSG00000171823
Gene ExpressionFBXL14 [ NCBI-GEO ]   FBXL14 [ EBI - ARRAY_EXPRESS ]   FBXL14 [ SEEK ]   FBXL14 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)144699
GTEX Portal (Tissue expression)FBXL14
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N1E6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N1E6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N1E6
Splice isoforms : SwissVarQ8N1E6
PhosPhoSitePlusQ8N1E6
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12937    pfam13516   
Domain families : Smart (EMBL)LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL14
DMDM Disease mutations144699
Blocks (Seattle)FBXL14
SuperfamilyQ8N1E6
Human Protein AtlasENSG00000171823
Peptide AtlasQ8N1E6
HPRD10949
IPIIPI00166145   
Protein Interaction databases
DIP (DOE-UCLA)Q8N1E6
IntAct (EBI)Q8N1E6
FunCoupENSG00000171823
BioGRIDFBXL14
STRING (EMBL)FBXL14
ZODIACFBXL14
Ontologies - Pathways
QuickGOQ8N1E6
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
NDEx NetworkFBXL14
Atlas of Cancer Signalling NetworkFBXL14
Wikipedia pathwaysFBXL14
Orthology - Evolution
OrthoDB144699
GeneTree (enSembl)ENSG00000171823
Phylogenetic Trees/Animal Genes : TreeFamFBXL14
HOVERGENQ8N1E6
HOGENOMQ8N1E6
Homologs : HomoloGeneFBXL14
Homology/Alignments : Family Browser (UCSC)FBXL14
Gene fusions - Rearrangements
Fusion : MitelmanANO2/FBXL14 [12p13.31/12p13.33]  [del(12)(p13p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL14
dbVarFBXL14
ClinVarFBXL14
1000_GenomesFBXL14 
Exome Variant ServerFBXL14
ExAC (Exome Aggregation Consortium)FBXL14 (select the gene name)
Genetic variants : HAPMAP144699
Genomic Variants (DGV)FBXL14 [DGVbeta]
DECIPHERFBXL14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL14 
Mutations
ICGC Data PortalFBXL14 
TCGA Data PortalFBXL14 
Broad Tumor PortalFBXL14
OASIS PortalFBXL14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL14
DgiDB (Drug Gene Interaction Database)FBXL14
DoCM (Curated mutations)FBXL14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL14 (select a term)
intoGenFBXL14
Cancer3DFBXL14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609081   
Orphanet
MedgenFBXL14
Genetic Testing Registry FBXL14
NextProtQ8N1E6 [Medical]
TSGene144699
GENETestsFBXL14
Target ValidationFBXL14
Huge Navigator FBXL14 [HugePedia]
snp3D : Map Gene to Disease144699
BioCentury BCIQFBXL14
ClinGenFBXL14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD144699
Chemical/Pharm GKB GenePA134979350
Clinical trialFBXL14
Miscellaneous
canSAR (ICR)FBXL14 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL14
EVEXFBXL14
GoPubMedFBXL14
iHOPFBXL14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:53:12 CEST 2017

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