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FBXL15 (F-box and leucine rich repeat protein 15)

Identity

Alias_namesFBXO37
F-box only protein 37
Alias_symbol (synonym)MGC11279
Fbl15
Other aliasJET
PSD
HGNC (Hugo) FBXL15
LocusID (NCBI) 79176
Atlas_Id 63313
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102419814 and ends at 102423136 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXL15 (10q24.32) / EGR1 (5q31.2)FBXL15 (10q24.32) / FASN (17q25.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL15   28155
Cards
Entrez_Gene (NCBI)FBXL15  79176  F-box and leucine rich repeat protein 15
AliasesFBXO37; Fbl15; JET; PSD
GeneCards (Weizmann)FBXL15
Ensembl hg19 (Hinxton)ENSG00000107872 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107872 [Gene_View]  chr10:102419814-102423136 [Contig_View]  FBXL15 [Vega]
ICGC DataPortalENSG00000107872
TCGA cBioPortalFBXL15
AceView (NCBI)FBXL15
Genatlas (Paris)FBXL15
WikiGenes79176
SOURCE (Princeton)FBXL15
Genetics Home Reference (NIH)FBXL15
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL15  -     chr10:102419814-102423136 +  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL15  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblFBXL15 - 10q24.32 [CytoView hg19]  FBXL15 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBIFBXL15 [Mapview hg19]  FBXL15 [Mapview hg38]
OMIM610287   
Gene and transcription
Genbank (Entrez)AK122684 BC002912 BC036120 BC130566 BI914195
RefSeq transcript (Entrez)NM_024326
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL15
Cluster EST : UnigeneHs.380081 [ NCBI ]
CGAP (NCI)Hs.380081
Alternative Splicing GalleryENSG00000107872
Gene ExpressionFBXL15 [ NCBI-GEO ]   FBXL15 [ EBI - ARRAY_EXPRESS ]   FBXL15 [ SEEK ]   FBXL15 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79176
GTEX Portal (Tissue expression)FBXL15
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H469   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H469  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H469
Splice isoforms : SwissVarQ9H469
PhosPhoSitePlusQ9H469
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box (PF00646)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam00646    pfam13516   
Domain families : Smart (EMBL)LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL15
DMDM Disease mutations79176
Blocks (Seattle)FBXL15
SuperfamilyQ9H469
Human Protein AtlasENSG00000107872
Peptide AtlasQ9H469
IPIIPI00793661   IPI00619919   IPI00402299   IPI00647153   IPI00645027   
Protein Interaction databases
DIP (DOE-UCLA)Q9H469
IntAct (EBI)Q9H469
FunCoupENSG00000107872
BioGRIDFBXL15
STRING (EMBL)FBXL15
ZODIACFBXL15
Ontologies - Pathways
QuickGOQ9H469
Ontology : AmiGOG2/M transition of mitotic cell cycle  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  dorsal/ventral pattern formation  protein ubiquitination  SCF ubiquitin ligase complex  bone mineralization  positive regulation of BMP signaling pathway  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  dorsal/ventral pattern formation  protein ubiquitination  SCF ubiquitin ligase complex  bone mineralization  positive regulation of BMP signaling pathway  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  
NDEx NetworkFBXL15
Atlas of Cancer Signalling NetworkFBXL15
Wikipedia pathwaysFBXL15
Orthology - Evolution
OrthoDB79176
GeneTree (enSembl)ENSG00000107872
Phylogenetic Trees/Animal Genes : TreeFamFBXL15
HOVERGENQ9H469
HOGENOMQ9H469
Homologs : HomoloGeneFBXL15
Homology/Alignments : Family Browser (UCSC)FBXL15
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL15
dbVarFBXL15
ClinVarFBXL15
1000_GenomesFBXL15 
Exome Variant ServerFBXL15
ExAC (Exome Aggregation Consortium)FBXL15 (select the gene name)
Genetic variants : HAPMAP79176
Genomic Variants (DGV)FBXL15 [DGVbeta]
DECIPHERFBXL15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL15 
Mutations
ICGC Data PortalFBXL15 
TCGA Data PortalFBXL15 
Broad Tumor PortalFBXL15
OASIS PortalFBXL15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL15
DgiDB (Drug Gene Interaction Database)FBXL15
DoCM (Curated mutations)FBXL15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL15 (select a term)
intoGenFBXL15
Cancer3DFBXL15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610287   
Orphanet
MedgenFBXL15
Genetic Testing Registry FBXL15
NextProtQ9H469 [Medical]
TSGene79176
GENETestsFBXL15
Target ValidationFBXL15
Huge Navigator FBXL15 [HugePedia]
snp3D : Map Gene to Disease79176
BioCentury BCIQFBXL15
ClinGenFBXL15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79176
Chemical/Pharm GKB GenePA134928704
Clinical trialFBXL15
Miscellaneous
canSAR (ICR)FBXL15 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL15
EVEXFBXL15
GoPubMedFBXL15
iHOPFBXL15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 15:48:59 CEST 2017

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