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FBXL2 (F-box and leucine-rich repeat protein 2)

Identity

Alias_symbol (synonym)FBL2
FBL3
Other alias
HGNC (Hugo) FBXL2
LocusID (NCBI) 25827
Atlas_Id 52859
Location 3p22.3  [Link to chromosome band 3p22]
Location_base_pair Starts at 33318937 and ends at 33428757 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FBXL2 (3p22.3) / FBXL2 (3p22.3)NCBP2 (3q29) / FBXL2 (3p22.3)TRAPPC4 (11q23.3) / FBXL2 (3p22.3)
UBAP2 (9p13.3) / FBXL2 (3p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL2   13598
Cards
Entrez_Gene (NCBI)FBXL2  25827  F-box and leucine-rich repeat protein 2
AliasesFBL2; FBL3
GeneCards (Weizmann)FBXL2
Ensembl hg19 (Hinxton)ENSG00000153558 [Gene_View]  chr3:33318937-33428757 [Contig_View]  FBXL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000153558 [Gene_View]  chr3:33318937-33428757 [Contig_View]  FBXL2 [Vega]
ICGC DataPortalENSG00000153558
TCGA cBioPortalFBXL2
AceView (NCBI)FBXL2
Genatlas (Paris)FBXL2
WikiGenes25827
SOURCE (Princeton)FBXL2
Genetics Home Reference (NIH)FBXL2
Genomic and cartography
GoldenPath hg19 (UCSC)FBXL2  -     chr3:33318937-33428757 +  3p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FBXL2  -     3p22.3   [Description]    (hg38-Dec_2013)
EnsemblFBXL2 - 3p22.3 [CytoView hg19]  FBXL2 - 3p22.3 [CytoView hg38]
Mapping of homologs : NCBIFBXL2 [Mapview hg19]  FBXL2 [Mapview hg38]
OMIM605652   
Gene and transcription
Genbank (Entrez)AF174589 AF176518 AF186273 AK001271 AK001438
RefSeq transcript (Entrez)NM_001171713 NM_012157
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)FBXL2
Cluster EST : UnigeneHs.475872 [ NCBI ]
CGAP (NCI)Hs.475872
Alternative Splicing GalleryENSG00000153558
Gene ExpressionFBXL2 [ NCBI-GEO ]   FBXL2 [ EBI - ARRAY_EXPRESS ]   FBXL2 [ SEEK ]   FBXL2 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25827
GTEX Portal (Tissue expression)FBXL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKC9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKC9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKC9
Splice isoforms : SwissVarQ9UKC9
PhosPhoSitePlusQ9UKC9
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)    LRR_1 (PF00560)   
Domain families : Pfam (NCBI)pfam12937    pfam00560   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL2
DMDM Disease mutations25827
Blocks (Seattle)FBXL2
SuperfamilyQ9UKC9
Human Protein AtlasENSG00000153558
Peptide AtlasQ9UKC9
HPRD05736
IPIIPI00296850   IPI01013406   IPI00909483   IPI00964856   IPI00925270   IPI00925795   IPI00924831   IPI00923623   IPI00927868   IPI00924995   IPI00927396   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKC9
IntAct (EBI)Q9UKC9
FunCoupENSG00000153558
BioGRIDFBXL2
STRING (EMBL)FBXL2
ZODIACFBXL2
Ontologies - Pathways
QuickGOQ9UKC9
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  calmodulin binding  cytoplasm  cellular protein modification process  proteolysis  protein monoubiquitination  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  membrane  viral process  protein ubiquitination  SCF ubiquitin ligase complex  protein phosphatase binding  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  phosphatidylinositol 3-kinase regulatory subunit binding  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  calmodulin binding  cytoplasm  cellular protein modification process  proteolysis  protein monoubiquitination  regulation of autophagy  regulation of phosphatidylinositol 3-kinase signaling  membrane  viral process  protein ubiquitination  SCF ubiquitin ligase complex  protein phosphatase binding  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  phosphatidylinositol 3-kinase regulatory subunit binding  
NDEx NetworkFBXL2
Atlas of Cancer Signalling NetworkFBXL2
Wikipedia pathwaysFBXL2
Orthology - Evolution
OrthoDB25827
GeneTree (enSembl)ENSG00000153558
Phylogenetic Trees/Animal Genes : TreeFamFBXL2
HOVERGENQ9UKC9
HOGENOMQ9UKC9
Homologs : HomoloGeneFBXL2
Homology/Alignments : Family Browser (UCSC)FBXL2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL2
dbVarFBXL2
ClinVarFBXL2
1000_GenomesFBXL2 
Exome Variant ServerFBXL2
ExAC (Exome Aggregation Consortium)FBXL2 (select the gene name)
Genetic variants : HAPMAP25827
Genomic Variants (DGV)FBXL2 [DGVbeta]
DECIPHER (Syndromes)3:33318937-33428757  ENSG00000153558
CONAN: Copy Number AnalysisFBXL2 
Mutations
ICGC Data PortalFBXL2 
TCGA Data PortalFBXL2 
Broad Tumor PortalFBXL2
OASIS PortalFBXL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL2
DgiDB (Drug Gene Interaction Database)FBXL2
DoCM (Curated mutations)FBXL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL2 (select a term)
intoGenFBXL2
Cancer3DFBXL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605652   
Orphanet
MedgenFBXL2
Genetic Testing Registry FBXL2
NextProtQ9UKC9 [Medical]
TSGene25827
GENETestsFBXL2
Huge Navigator FBXL2 [HugePedia]
snp3D : Map Gene to Disease25827
BioCentury BCIQFBXL2
ClinGenFBXL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25827
Chemical/Pharm GKB GenePA28021
Clinical trialFBXL2
Miscellaneous
canSAR (ICR)FBXL2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL2
EVEXFBXL2
GoPubMedFBXL2
iHOPFBXL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:05:44 CET 2017

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