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FBXL20 (F-box and leucine rich repeat protein 20)

Identity

Alias (NCBI)Fbl2
Fbl20
HGNC (Hugo) FBXL20
HGNC Alias symbMGC15482
Fbl2
Fbl20
LocusID (NCBI) 84961
Atlas_Id 53274
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39252663 and ends at 39401626 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AARSD1 (17q21.31)::FBXL20 (17q12)CANT1 (17q25.3)::FBXL20 (17q12)CDK12 (17q12)::FBXL20 (17q12)
FBXL20 (17q12)::BCAS3 (17q23.2)FBXL20 (17q12)::CDK12 (17q12)FBXL20 (17q12)::FBXL20 (17q12)
FBXL20 (17q12)::GDPD5 (11q13.4)FBXL20 (17q12)::SNF8 (17q21.32)FBXL20 (17q12)::TLK2 (17q23.2)
SMG7 (1q25.3)::FBXL20 (17q12)AARSD1 17q21.31::FBXL20 17q12CANT1 17q25.3::FBXL20 17q12
CDK12 17q12::FBXL20 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FBXL20   24679
Cards
Entrez_Gene (NCBI)FBXL20    F-box and leucine rich repeat protein 20
AliasesFbl2; Fbl20
GeneCards (Weizmann)FBXL20
Ensembl hg19 (Hinxton)ENSG00000108306 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108306 [Gene_View]  ENSG00000108306 [Sequence]  chr17:39252663-39401626 [Contig_View]  FBXL20 [Vega]
ICGC DataPortalENSG00000108306
TCGA cBioPortalFBXL20
AceView (NCBI)FBXL20
Genatlas (Paris)FBXL20
SOURCE (Princeton)FBXL20
Genetics Home Reference (NIH)FBXL20
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL20  -     chr17:39252663-39401626 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL20  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathFBXL20 - 17q12 [CytoView hg19]  FBXL20 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000108306
Genome Data Viewer NCBIFBXL20 [Mapview hg19]  
OMIM609086   
Gene and transcription
Genbank (Entrez)AK024690 AK123048 AK291844 AK312612 AL117623
RefSeq transcript (Entrez)NM_001184906 NM_001370208 NM_001370209 NM_032875
Consensus coding sequences : CCDS (NCBI)FBXL20
Gene ExpressionFBXL20 [ NCBI-GEO ]   FBXL20 [ EBI - ARRAY_EXPRESS ]   FBXL20 [ SEEK ]   FBXL20 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL20 [ Firebrowse - Broad ]
GenevisibleExpression of FBXL20 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84961
GTEX Portal (Tissue expression)FBXL20
Human Protein AtlasENSG00000108306-FBXL20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96IG2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96IG2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96IG2
PhosPhoSitePlusQ96IG2
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp    LRR_dom_sf   
Domain families : Pfam (Sanger)F-box-like (PF12937)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12937    pfam13516   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL20
SuperfamilyQ96IG2
AlphaFold pdb e-kbQ96IG2   
Human Protein Atlas [tissue]ENSG00000108306-FBXL20 [tissue]
HPRD10951
Protein Interaction databases
DIP (DOE-UCLA)Q96IG2
IntAct (EBI)Q96IG2
BioGRIDFBXL20
STRING (EMBL)FBXL20
ZODIACFBXL20
Ontologies - Pathways
QuickGOQ96IG2
Ontology : AmiGObehavioral fear response  protein binding  cytosol  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  Schaffer collateral - CA1 synapse  presynapse  glutamatergic synapse  regulation of protein catabolic process at presynapse, modulating synaptic transmission  regulation of synaptic vesicle exocytosis  
Ontology : EGO-EBIbehavioral fear response  protein binding  cytosol  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  Schaffer collateral - CA1 synapse  presynapse  glutamatergic synapse  regulation of protein catabolic process at presynapse, modulating synaptic transmission  regulation of synaptic vesicle exocytosis  
NDEx NetworkFBXL20
Atlas of Cancer Signalling NetworkFBXL20
Wikipedia pathwaysFBXL20
Orthology - Evolution
OrthoDB84961
GeneTree (enSembl)ENSG00000108306
Phylogenetic Trees/Animal Genes : TreeFamFBXL20
Homologs : HomoloGeneFBXL20
Homology/Alignments : Family Browser (UCSC)FBXL20
Gene fusions - Rearrangements
Fusion : MitelmanAARSD1::FBXL20 [17q21.31/17q12]  
Fusion : MitelmanCANT1::FBXL20 [17q25.3/17q12]  
Fusion : MitelmanFBXL20::GDPD5 [17q12/11q13.4]  
Fusion : MitelmanFBXL20::SNF8 [17q12/17q21.32]  
Fusion : MitelmanFBXL20::TLK2 [17q12/17q23.2]  
Fusion : QuiverFBXL20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL20
dbVarFBXL20
ClinVarFBXL20
MonarchFBXL20
1000_GenomesFBXL20 
Exome Variant ServerFBXL20
GNOMAD BrowserENSG00000108306
Varsome BrowserFBXL20
ACMGFBXL20 variants
VarityQ96IG2
Genomic Variants (DGV)FBXL20 [DGVbeta]
DECIPHERFBXL20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL20 
Mutations
ICGC Data PortalFBXL20 
TCGA Data PortalFBXL20 
Broad Tumor PortalFBXL20
OASIS PortalFBXL20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL20  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFBXL20
Mutations and Diseases : HGMDFBXL20
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFBXL20
DgiDB (Drug Gene Interaction Database)FBXL20
DoCM (Curated mutations)FBXL20
CIViC (Clinical Interpretations of Variants in Cancer)FBXL20
Cancer3DFBXL20
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609086   
Orphanet
DisGeNETFBXL20
MedgenFBXL20
Genetic Testing Registry FBXL20
NextProtQ96IG2 [Medical]
GENETestsFBXL20
Target ValidationFBXL20
Huge Navigator FBXL20 [HugePedia]
ClinGenFBXL20
Clinical trials, drugs, therapy
MyCancerGenomeFBXL20
Protein Interactions : CTDFBXL20
Pharm GKB GenePA134976410
PharosQ96IG2
Clinical trialFBXL20
Miscellaneous
canSAR (ICR)FBXL20
HarmonizomeFBXL20
ARCHS4FBXL20
DataMed IndexFBXL20
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFBXL20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:33:13 CET 2022

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