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FBXL20 (F-box and leucine rich repeat protein 20)

Identity

Alias_symbol (synonym)MGC15482
Fbl2
Fbl20
Other alias
HGNC (Hugo) FBXL20
LocusID (NCBI) 84961
Atlas_Id 53274
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 39252644 and ends at 39401656 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AARSD1 (17q21.31) / FBXL20 (17q12)CANT1 (17q25.3) / FBXL20 (17q12)CDK12 (17q12) / FBXL20 (17q12)
FBXL20 (17q12) / BCAS3 (17q23.2)FBXL20 (17q12) / CDK12 (17q12)FBXL20 (17q12) / FBXL20 (17q12)
FBXL20 (17q12) / GDPD5 (11q13.4)FBXL20 (17q12) / SNF8 (17q21.32)FBXL20 (17q12) / TLK2 (17q23.2)
SMG7 (1q25.3) / FBXL20 (17q12)AARSD1 17q21.31 / FBXL20 17q12CANT1 17q25.3 / FBXL20 17q12
CDK12 17q12 / FBXL20 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL20   24679
Cards
Entrez_Gene (NCBI)FBXL20  84961  F-box and leucine rich repeat protein 20
AliasesFbl2; Fbl20
GeneCards (Weizmann)FBXL20
Ensembl hg19 (Hinxton)ENSG00000108306 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108306 [Gene_View]  chr17:39252644-39401656 [Contig_View]  FBXL20 [Vega]
ICGC DataPortalENSG00000108306
TCGA cBioPortalFBXL20
AceView (NCBI)FBXL20
Genatlas (Paris)FBXL20
WikiGenes84961
SOURCE (Princeton)FBXL20
Genetics Home Reference (NIH)FBXL20
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL20  -     chr17:39252644-39401656 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL20  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblFBXL20 - 17q12 [CytoView hg19]  FBXL20 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIFBXL20 [Mapview hg19]  FBXL20 [Mapview hg38]
OMIM609086   
Gene and transcription
Genbank (Entrez)AK024690 AK123048 AK291844 AK312612 AL117623
RefSeq transcript (Entrez)NM_001184906 NM_032875
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL20
Cluster EST : UnigeneHs.462946 [ NCBI ]
CGAP (NCI)Hs.462946
Alternative Splicing GalleryENSG00000108306
Gene ExpressionFBXL20 [ NCBI-GEO ]   FBXL20 [ EBI - ARRAY_EXPRESS ]   FBXL20 [ SEEK ]   FBXL20 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84961
GTEX Portal (Tissue expression)FBXL20
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96IG2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96IG2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96IG2
Splice isoforms : SwissVarQ96IG2
PhosPhoSitePlusQ96IG2
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12937    pfam13516   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL20
DMDM Disease mutations84961
Blocks (Seattle)FBXL20
SuperfamilyQ96IG2
Human Protein AtlasENSG00000108306
Peptide AtlasQ96IG2
HPRD10951
IPIIPI00174757   IPI00655936   
Protein Interaction databases
DIP (DOE-UCLA)Q96IG2
IntAct (EBI)Q96IG2
FunCoupENSG00000108306
BioGRIDFBXL20
STRING (EMBL)FBXL20
ZODIACFBXL20
Ontologies - Pathways
QuickGOQ96IG2
Ontology : AmiGOprotein polyubiquitination  behavioral fear response  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  
Ontology : EGO-EBIprotein polyubiquitination  behavioral fear response  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  
NDEx NetworkFBXL20
Atlas of Cancer Signalling NetworkFBXL20
Wikipedia pathwaysFBXL20
Orthology - Evolution
OrthoDB84961
GeneTree (enSembl)ENSG00000108306
Phylogenetic Trees/Animal Genes : TreeFamFBXL20
HOVERGENQ96IG2
HOGENOMQ96IG2
Homologs : HomoloGeneFBXL20
Homology/Alignments : Family Browser (UCSC)FBXL20
Gene fusions - Rearrangements
Fusion : MitelmanAARSD1/FBXL20 [17q21.31/17q12]  [t(17;17)(q12;q21)]  
Fusion : MitelmanCANT1/FBXL20 [17q25.3/17q12]  [t(17;17)(q12;q25)]  
Fusion : MitelmanFBXL20/GDPD5 [17q12/11q13.4]  [t(11;17)(q13;q12)]  
Fusion : MitelmanFBXL20/SNF8 [17q12/17q21.32]  [t(17;17)(q12;q21)]  
Fusion : MitelmanFBXL20/TLK2 [17q12/17q23.2]  [t(17;17)(q12;q23)]  
Fusion: TCGAAARSD1 17q21.31 FBXL20 17q12 BLCA
Fusion: TCGACANT1 17q25.3 FBXL20 17q12 BRCA
Fusion: TCGACDK12 17q12 FBXL20 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL20
dbVarFBXL20
ClinVarFBXL20
1000_GenomesFBXL20 
Exome Variant ServerFBXL20
ExAC (Exome Aggregation Consortium)FBXL20 (select the gene name)
Genetic variants : HAPMAP84961
Genomic Variants (DGV)FBXL20 [DGVbeta]
DECIPHERFBXL20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL20 
Mutations
ICGC Data PortalFBXL20 
TCGA Data PortalFBXL20 
Broad Tumor PortalFBXL20
OASIS PortalFBXL20 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL20  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL20
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL20
DgiDB (Drug Gene Interaction Database)FBXL20
DoCM (Curated mutations)FBXL20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL20 (select a term)
intoGenFBXL20
Cancer3DFBXL20(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609086   
Orphanet
MedgenFBXL20
Genetic Testing Registry FBXL20
NextProtQ96IG2 [Medical]
TSGene84961
GENETestsFBXL20
Target ValidationFBXL20
Huge Navigator FBXL20 [HugePedia]
snp3D : Map Gene to Disease84961
BioCentury BCIQFBXL20
ClinGenFBXL20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84961
Chemical/Pharm GKB GenePA134976410
Clinical trialFBXL20
Miscellaneous
canSAR (ICR)FBXL20 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL20
EVEXFBXL20
GoPubMedFBXL20
iHOPFBXL20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:33 CEST 2017

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