FBXL20 (F-box and leucine rich repeat protein 20)

2013-05-01  

Identity

HGNC
FBXL20
LOCATION
17q12
LOCUSID
84961
ALIAS
Fbl2,Fbl20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84961
MIM: 609086
HGNC: 24679
Ensembl: ENSG00000108306

Variants:

dbSNP: 84961
ClinVar: 84961
TCGA: ENSG00000108306
COSMIC: FBXL20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108306ENST00000264658Q96IG2
ENSG00000108306ENST00000394294Q96IG2
ENSG00000108306ENST00000577399J3KTA1
ENSG00000108306ENST00000581781J3QKL3
ENSG00000108306ENST00000583610Q96IG2
ENSG00000108306ENST00000647139A0A2R8Y677

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191245062009Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.22
255933082015FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.22
230235842012Role of FBXL20 in human colorectal adenocarcinoma.13

Citation

Dessen P

FBXL20 (F-box and leucine rich repeat protein 20)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53274/fbxl20