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FBXL3 (F-box and leucine rich repeat protein 3)

Identity

Alias_namesFBXL3A
F-box and leucine-rich repeat protein 3A
Alias_symbol (synonym)FBL3
FBL3A
Other alias
HGNC (Hugo) FBXL3
LocusID (NCBI) 26224
Atlas_Id 54314
Location 13q22.3  [Link to chromosome band 13q22]
Location_base_pair Starts at 77005254 and ends at 77027196 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLN5 (13q22.3) / FBXL3 (13q22.3)FBXL3 (13q22.3) / C20orf27 (20p13)FBXL3 (13q22.3) / IER3IP1 (18q21.1)
FBXL3 (13q22.3) / KLF5 (13q22.1)FBXL3 13q22.3 / KLF5 13q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL3   13599
Cards
Entrez_Gene (NCBI)FBXL3  26224  F-box and leucine rich repeat protein 3
AliasesFBL3; FBL3A; FBXL3A
GeneCards (Weizmann)FBXL3
Ensembl hg19 (Hinxton)ENSG00000005812 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005812 [Gene_View]  chr13:77005254-77027196 [Contig_View]  FBXL3 [Vega]
ICGC DataPortalENSG00000005812
TCGA cBioPortalFBXL3
AceView (NCBI)FBXL3
Genatlas (Paris)FBXL3
WikiGenes26224
SOURCE (Princeton)FBXL3
Genetics Home Reference (NIH)FBXL3
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL3  -     chr13:77005254-77027196 -  13q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL3  -     13q22.3   [Description]    (hg19-Feb_2009)
EnsemblFBXL3 - 13q22.3 [CytoView hg19]  FBXL3 - 13q22.3 [CytoView hg38]
Mapping of homologs : NCBIFBXL3 [Mapview hg19]  FBXL3 [Mapview hg38]
OMIM605653   
Gene and transcription
Genbank (Entrez)AF126028 AF129532 AI133484 AK025484 AK314442
RefSeq transcript (Entrez)NM_012158
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL3
Cluster EST : UnigeneHs.508284 [ NCBI ]
CGAP (NCI)Hs.508284
Alternative Splicing GalleryENSG00000005812
Gene ExpressionFBXL3 [ NCBI-GEO ]   FBXL3 [ EBI - ARRAY_EXPRESS ]   FBXL3 [ SEEK ]   FBXL3 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26224
GTEX Portal (Tissue expression)FBXL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKT7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKT7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKT7
Splice isoforms : SwissVarQ9UKT7
PhosPhoSitePlusQ9UKT7
Domains : Interpro (EBI)F-box_dom    L_dom-like   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXL3
DMDM Disease mutations26224
Blocks (Seattle)FBXL3
PDB (SRS)4I6J   
PDB (PDBSum)4I6J   
PDB (IMB)4I6J   
PDB (RSDB)4I6J   
Structural Biology KnowledgeBase4I6J   
SCOP (Structural Classification of Proteins)4I6J   
CATH (Classification of proteins structures)4I6J   
SuperfamilyQ9UKT7
Human Protein AtlasENSG00000005812
Peptide AtlasQ9UKT7
HPRD05737
IPIIPI00164336   IPI00642371   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKT7
IntAct (EBI)Q9UKT7
FunCoupENSG00000005812
BioGRIDFBXL3
STRING (EMBL)FBXL3
ZODIACFBXL3
Ontologies - Pathways
QuickGOQ9UKT7
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytosol  cytosol  protein ubiquitination  protein ubiquitination  nuclear body  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  protein destabilization  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  rhythmic process  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytosol  cytosol  protein ubiquitination  protein ubiquitination  nuclear body  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  protein destabilization  regulation of circadian rhythm  entrainment of circadian clock by photoperiod  rhythmic process  
Pathways : KEGGCircadian rhythm   
NDEx NetworkFBXL3
Atlas of Cancer Signalling NetworkFBXL3
Wikipedia pathwaysFBXL3
Orthology - Evolution
OrthoDB26224
GeneTree (enSembl)ENSG00000005812
Phylogenetic Trees/Animal Genes : TreeFamFBXL3
HOVERGENQ9UKT7
HOGENOMQ9UKT7
Homologs : HomoloGeneFBXL3
Homology/Alignments : Family Browser (UCSC)FBXL3
Gene fusions - Rearrangements
Fusion : MitelmanCLN5/FBXL3 [13q22.3/13q22.3]  [t(13;13)(q22;q22)]  
Fusion : MitelmanFBXL3/KLF5 [13q22.3/13q22.1]  [t(13;13)(q22;q22)]  
Fusion: TCGAFBXL3 13q22.3 KLF5 13q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL3
dbVarFBXL3
ClinVarFBXL3
1000_GenomesFBXL3 
Exome Variant ServerFBXL3
ExAC (Exome Aggregation Consortium)FBXL3 (select the gene name)
Genetic variants : HAPMAP26224
Genomic Variants (DGV)FBXL3 [DGVbeta]
DECIPHERFBXL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL3 
Mutations
ICGC Data PortalFBXL3 
TCGA Data PortalFBXL3 
Broad Tumor PortalFBXL3
OASIS PortalFBXL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL3
DgiDB (Drug Gene Interaction Database)FBXL3
DoCM (Curated mutations)FBXL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL3 (select a term)
intoGenFBXL3
Cancer3DFBXL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605653   
Orphanet
MedgenFBXL3
Genetic Testing Registry FBXL3
NextProtQ9UKT7 [Medical]
TSGene26224
GENETestsFBXL3
Target ValidationFBXL3
Huge Navigator FBXL3 [HugePedia]
snp3D : Map Gene to Disease26224
BioCentury BCIQFBXL3
ClinGenFBXL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26224
Chemical/Pharm GKB GenePA28022
Clinical trialFBXL3
Miscellaneous
canSAR (ICR)FBXL3 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL3
EVEXFBXL3
GoPubMedFBXL3
iHOPFBXL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:01:01 CEST 2017

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