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FBXL4 (F-box and leucine rich repeat protein 4)

Identity

Alias_symbol (synonym)FBL4
FBL5
Other aliasMTDPS13
HGNC (Hugo) FBXL4
LocusID (NCBI) 26235
Atlas_Id 63317
Location 6q16.1  [Link to chromosome band 6q16]
Location_base_pair Starts at 98873725 and ends at 98948006 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXL4 (6q16.1) / APBA2 (15q13.1)FBXL4 (6q16.1) / CTTN (11q13.3)FBXL4 (6q16.1) / GOPC (6q22.1)
FBXL4 (6q16.1) / PROX1 (1q32.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL4   13601
Cards
Entrez_Gene (NCBI)FBXL4  26235  F-box and leucine rich repeat protein 4
AliasesFBL4; FBL5; MTDPS13
GeneCards (Weizmann)FBXL4
Ensembl hg19 (Hinxton)ENSG00000112234 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112234 [Gene_View]  ENSG00000112234 [Sequence]  chr6:98873725-98948006 [Contig_View]  FBXL4 [Vega]
ICGC DataPortalENSG00000112234
TCGA cBioPortalFBXL4
AceView (NCBI)FBXL4
Genatlas (Paris)FBXL4
WikiGenes26235
SOURCE (Princeton)FBXL4
Genetics Home Reference (NIH)FBXL4
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL4  -     chr6:98873725-98948006 -  6q16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL4  -     6q16.1   [Description]    (hg19-Feb_2009)
EnsemblFBXL4 - 6q16.1 [CytoView hg19]  FBXL4 - 6q16.1 [CytoView hg38]
Mapping of homologs : NCBIFBXL4 [Mapview hg19]  FBXL4 [Mapview hg38]
OMIM605654   615471   
Gene and transcription
Genbank (Entrez)AF174590 AF176699 AF199355 AI935511 AJ420594
RefSeq transcript (Entrez)NM_001278716 NM_012160
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL4
Cluster EST : UnigeneHs.714504 [ NCBI ]
CGAP (NCI)Hs.714504
Alternative Splicing GalleryENSG00000112234
Gene ExpressionFBXL4 [ NCBI-GEO ]   FBXL4 [ EBI - ARRAY_EXPRESS ]   FBXL4 [ SEEK ]   FBXL4 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26235
GTEX Portal (Tissue expression)FBXL4
Human Protein AtlasENSG00000112234-FBXL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKA2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKA2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKA2
Splice isoforms : SwissVarQ9UKA2
PhosPhoSitePlusQ9UKA2
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box (PF00646)   
Domain families : Pfam (NCBI)pfam00646   
Domain families : Smart (EMBL)LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL4
DMDM Disease mutations26235
Blocks (Seattle)FBXL4
SuperfamilyQ9UKA2
Human Protein Atlas [tissue]ENSG00000112234-FBXL4 [tissue]
Peptide AtlasQ9UKA2
HPRD05738
IPIIPI00145799   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKA2
IntAct (EBI)Q9UKA2
FunCoupENSG00000112234
BioGRIDFBXL4
STRING (EMBL)FBXL4
ZODIACFBXL4
Ontologies - Pathways
QuickGOQ9UKA2
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  mitochondrial intermembrane space  cytosol  ubiquitin-dependent protein catabolic process  nuclear speck  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  mitochondrial intermembrane space  cytosol  ubiquitin-dependent protein catabolic process  nuclear speck  
NDEx NetworkFBXL4
Atlas of Cancer Signalling NetworkFBXL4
Wikipedia pathwaysFBXL4
Orthology - Evolution
OrthoDB26235
GeneTree (enSembl)ENSG00000112234
Phylogenetic Trees/Animal Genes : TreeFamFBXL4
HOVERGENQ9UKA2
HOGENOMQ9UKA2
Homologs : HomoloGeneFBXL4
Homology/Alignments : Family Browser (UCSC)FBXL4
Gene fusions - Rearrangements
Fusion : QuiverFBXL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL4
dbVarFBXL4
ClinVarFBXL4
1000_GenomesFBXL4 
Exome Variant ServerFBXL4
ExAC (Exome Aggregation Consortium)ENSG00000112234
GNOMAD BrowserENSG00000112234
Varsome BrowserFBXL4
Genetic variants : HAPMAP26235
Genomic Variants (DGV)FBXL4 [DGVbeta]
DECIPHERFBXL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL4 
Mutations
ICGC Data PortalFBXL4 
TCGA Data PortalFBXL4 
Broad Tumor PortalFBXL4
OASIS PortalFBXL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch FBXL4
DgiDB (Drug Gene Interaction Database)FBXL4
DoCM (Curated mutations)FBXL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL4 (select a term)
intoGenFBXL4
Cancer3DFBXL4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605654    615471   
Orphanet22445   
DisGeNETFBXL4
MedgenFBXL4
Genetic Testing Registry FBXL4
NextProtQ9UKA2 [Medical]
TSGene26235
GENETestsFBXL4
Target ValidationFBXL4
Huge Navigator FBXL4 [HugePedia]
snp3D : Map Gene to Disease26235
BioCentury BCIQFBXL4
ClinGenFBXL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26235
Chemical/Pharm GKB GenePA28024
Clinical trialFBXL4
Miscellaneous
canSAR (ICR)FBXL4 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL4
EVEXFBXL4
GoPubMedFBXL4
iHOPFBXL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:45:47 CEST 2018

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