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FBXL5 (F-box and leucine rich repeat protein 5)

Identity

Alias_symbol (synonym)FBL4
FBL5
FLR1
Other alias
HGNC (Hugo) FBXL5
LocusID (NCBI) 26234
Atlas_Id 55008
Location 4p15.32  [Link to chromosome band 4p15]
Location_base_pair Starts at 15604384 and ends at 15655412 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PXT1 (6p21.31) / FBXL5 (4p15.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL5   13602
Cards
Entrez_Gene (NCBI)FBXL5  26234  F-box and leucine rich repeat protein 5
AliasesFBL4; FBL5; FLR1
GeneCards (Weizmann)FBXL5
Ensembl hg19 (Hinxton)ENSG00000118564 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118564 [Gene_View]  chr4:15604384-15655412 [Contig_View]  FBXL5 [Vega]
ICGC DataPortalENSG00000118564
TCGA cBioPortalFBXL5
AceView (NCBI)FBXL5
Genatlas (Paris)FBXL5
WikiGenes26234
SOURCE (Princeton)FBXL5
Genetics Home Reference (NIH)FBXL5
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL5  -     chr4:15604384-15655412 -  4p15.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL5  -     4p15.32   [Description]    (hg19-Feb_2009)
EnsemblFBXL5 - 4p15.32 [CytoView hg19]  FBXL5 - 4p15.32 [CytoView hg38]
Mapping of homologs : NCBIFBXL5 [Mapview hg19]  FBXL5 [Mapview hg38]
OMIM605655   
Gene and transcription
Genbank (Entrez)AF052097 AF142481 AF157323 AF174591 AF176700
RefSeq transcript (Entrez)NM_001193534 NM_001193535 NM_012161
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL5
Cluster EST : UnigeneHs.714386 [ NCBI ]
CGAP (NCI)Hs.714386
Alternative Splicing GalleryENSG00000118564
Gene ExpressionFBXL5 [ NCBI-GEO ]   FBXL5 [ EBI - ARRAY_EXPRESS ]   FBXL5 [ SEEK ]   FBXL5 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26234
GTEX Portal (Tissue expression)FBXL5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKA1
Splice isoforms : SwissVarQ9UKA1
PhosPhoSitePlusQ9UKA1
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    Haemerythrin-like    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)    Hemerythrin (PF01814)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12937    pfam01814    pfam13516   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL5
DMDM Disease mutations26234
Blocks (Seattle)FBXL5
PDB (SRS)3U9J    3U9M    3V5X    3V5Y    3V5Z   
PDB (PDBSum)3U9J    3U9M    3V5X    3V5Y    3V5Z   
PDB (IMB)3U9J    3U9M    3V5X    3V5Y    3V5Z   
PDB (RSDB)3U9J    3U9M    3V5X    3V5Y    3V5Z   
Structural Biology KnowledgeBase3U9J    3U9M    3V5X    3V5Y    3V5Z   
SCOP (Structural Classification of Proteins)3U9J    3U9M    3V5X    3V5Y    3V5Z   
CATH (Classification of proteins structures)3U9J    3U9M    3V5X    3V5Y    3V5Z   
SuperfamilyQ9UKA1
Human Protein AtlasENSG00000118564
Peptide AtlasQ9UKA1
HPRD05739
IPIIPI00099395   IPI00374569   IPI00965853   IPI00965594   IPI00965362   IPI00963919   IPI00966542   IPI00964231   IPI00964533   IPI00964690   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKA1
IntAct (EBI)Q9UKA1
FunCoupENSG00000118564
BioGRIDFBXL5
STRING (EMBL)FBXL5
ZODIACFBXL5
Ontologies - Pathways
QuickGOQ9UKA1
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  iron ion binding  protein binding  cytosol  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  perinuclear region of cytoplasm  iron ion homeostasis  iron ion homeostasis  positive regulation of cellular protein catabolic process  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  iron ion binding  protein binding  cytosol  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  perinuclear region of cytoplasm  iron ion homeostasis  iron ion homeostasis  positive regulation of cellular protein catabolic process  
NDEx NetworkFBXL5
Atlas of Cancer Signalling NetworkFBXL5
Wikipedia pathwaysFBXL5
Orthology - Evolution
OrthoDB26234
GeneTree (enSembl)ENSG00000118564
Phylogenetic Trees/Animal Genes : TreeFamFBXL5
HOVERGENQ9UKA1
HOGENOMQ9UKA1
Homologs : HomoloGeneFBXL5
Homology/Alignments : Family Browser (UCSC)FBXL5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL5
dbVarFBXL5
ClinVarFBXL5
1000_GenomesFBXL5 
Exome Variant ServerFBXL5
ExAC (Exome Aggregation Consortium)FBXL5 (select the gene name)
Genetic variants : HAPMAP26234
Genomic Variants (DGV)FBXL5 [DGVbeta]
DECIPHERFBXL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL5 
Mutations
ICGC Data PortalFBXL5 
TCGA Data PortalFBXL5 
Broad Tumor PortalFBXL5
OASIS PortalFBXL5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL5
DgiDB (Drug Gene Interaction Database)FBXL5
DoCM (Curated mutations)FBXL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL5 (select a term)
intoGenFBXL5
Cancer3DFBXL5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605655   
Orphanet
MedgenFBXL5
Genetic Testing Registry FBXL5
NextProtQ9UKA1 [Medical]
TSGene26234
GENETestsFBXL5
Target ValidationFBXL5
Huge Navigator FBXL5 [HugePedia]
snp3D : Map Gene to Disease26234
BioCentury BCIQFBXL5
ClinGenFBXL5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26234
Chemical/Pharm GKB GenePA28025
Clinical trialFBXL5
Miscellaneous
canSAR (ICR)FBXL5 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL5
EVEXFBXL5
GoPubMedFBXL5
iHOPFBXL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:08:02 CEST 2017

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