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FBXL7 (F-box and leucine rich repeat protein 7)

Identity

Alias_symbol (synonym)KIAA0840
FBL7
FBL6
Other alias
HGNC (Hugo) FBXL7
LocusID (NCBI) 23194
Atlas_Id 47427
Location 5p15.1  [Link to chromosome band 5p15]
Location_base_pair Starts at 15501438 and ends at 15939796 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXL7 (5p15.1) / ARFGEF1 (8q13.2)FBXL7 (5p15.1) / TRIO (5p15.2)FBXL7 (5p15.1) / ZNF644 (1p22.2)
GAPDH (12p13.31) / FBXL7 (5p15.1)SMCHD1 (18p11.32) / FBXL7 (5p15.1)TRIO (5p15.2) / FBXL7 (5p15.1)
TRIO 5p15.2 / FBXL7 5p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL7   13604
Cards
Entrez_Gene (NCBI)FBXL7  23194  F-box and leucine rich repeat protein 7
AliasesFBL6; FBL7
GeneCards (Weizmann)FBXL7
Ensembl hg19 (Hinxton)ENSG00000183580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183580 [Gene_View]  chr5:15501438-15939796 [Contig_View]  FBXL7 [Vega]
ICGC DataPortalENSG00000183580
TCGA cBioPortalFBXL7
AceView (NCBI)FBXL7
Genatlas (Paris)FBXL7
WikiGenes23194
SOURCE (Princeton)FBXL7
Genetics Home Reference (NIH)FBXL7
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL7  -     chr5:15501438-15939796 +  5p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL7  -     5p15.1   [Description]    (hg19-Feb_2009)
EnsemblFBXL7 - 5p15.1 [CytoView hg19]  FBXL7 - 5p15.1 [CytoView hg38]
Mapping of homologs : NCBIFBXL7 [Mapview hg19]  FBXL7 [Mapview hg38]
OMIM605656   
Gene and transcription
Genbank (Entrez)AB020647 AF174593 AF199356 AK021671 AK309585
RefSeq transcript (Entrez)NM_001278317 NM_012304
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL7
Cluster EST : UnigeneHs.433057 [ NCBI ]
CGAP (NCI)Hs.433057
Alternative Splicing GalleryENSG00000183580
Gene ExpressionFBXL7 [ NCBI-GEO ]   FBXL7 [ EBI - ARRAY_EXPRESS ]   FBXL7 [ SEEK ]   FBXL7 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23194
GTEX Portal (Tissue expression)FBXL7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UJT9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UJT9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UJT9
Splice isoforms : SwissVarQ9UJT9
PhosPhoSitePlusQ9UJT9
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_Cys-con_subtyp   
Domain families : Pfam (Sanger)F-box-like (PF12937)    LRR_6 (PF13516)   
Domain families : Pfam (NCBI)pfam12937    pfam13516   
Domain families : Smart (EMBL)FBOX (SM00256)  LRR_CC (SM00367)  
Conserved Domain (NCBI)FBXL7
DMDM Disease mutations23194
Blocks (Seattle)FBXL7
SuperfamilyQ9UJT9
Human Protein AtlasENSG00000183580
Peptide AtlasQ9UJT9
HPRD05740
IPIIPI00017566   IPI00816435   IPI00967207   
Protein Interaction databases
DIP (DOE-UCLA)Q9UJT9
IntAct (EBI)Q9UJT9
FunCoupENSG00000183580
BioGRIDFBXL7
STRING (EMBL)FBXL7
ZODIACFBXL7
Ontologies - Pathways
QuickGOQ9UJT9
Ontology : AmiGOG2/M transition of mitotic cell cycle  ubiquitin ligase complex  protein polyubiquitination  mitotic cell cycle  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  centrosome  cytosol  ubiquitin-dependent protein catabolic process  cell proliferation  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cell division  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  ubiquitin ligase complex  protein polyubiquitination  mitotic cell cycle  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  centrosome  cytosol  ubiquitin-dependent protein catabolic process  cell proliferation  SCF complex assembly  negative regulation of G2/M transition of mitotic cell cycle  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  cell division  
NDEx NetworkFBXL7
Atlas of Cancer Signalling NetworkFBXL7
Wikipedia pathwaysFBXL7
Orthology - Evolution
OrthoDB23194
GeneTree (enSembl)ENSG00000183580
Phylogenetic Trees/Animal Genes : TreeFamFBXL7
HOVERGENQ9UJT9
HOGENOMQ9UJT9
Homologs : HomoloGeneFBXL7
Homology/Alignments : Family Browser (UCSC)FBXL7
Gene fusions - Rearrangements
Fusion : MitelmanTRIO/FBXL7 [5p15.2/5p15.1]  [t(5;5)(p15;p15)]  
Fusion: TCGATRIO 5p15.2 FBXL7 5p15.1 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL7
dbVarFBXL7
ClinVarFBXL7
1000_GenomesFBXL7 
Exome Variant ServerFBXL7
ExAC (Exome Aggregation Consortium)FBXL7 (select the gene name)
Genetic variants : HAPMAP23194
Genomic Variants (DGV)FBXL7 [DGVbeta]
DECIPHERFBXL7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL7 
Mutations
ICGC Data PortalFBXL7 
TCGA Data PortalFBXL7 
Broad Tumor PortalFBXL7
OASIS PortalFBXL7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL7
DgiDB (Drug Gene Interaction Database)FBXL7
DoCM (Curated mutations)FBXL7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL7 (select a term)
intoGenFBXL7
Cancer3DFBXL7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605656   
Orphanet
MedgenFBXL7
Genetic Testing Registry FBXL7
NextProtQ9UJT9 [Medical]
TSGene23194
GENETestsFBXL7
Target ValidationFBXL7
Huge Navigator FBXL7 [HugePedia]
snp3D : Map Gene to Disease23194
BioCentury BCIQFBXL7
ClinGenFBXL7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23194
Chemical/Pharm GKB GenePA28027
Clinical trialFBXL7
Miscellaneous
canSAR (ICR)FBXL7 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL7
EVEXFBXL7
GoPubMedFBXL7
iHOPFBXL7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:34 CEST 2017

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