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FBXL8 (F-box and leucine rich repeat protein 8)

Identity

Alias_symbol (synonym)Fbl8
Other aliasFBL8
HGNC (Hugo) FBXL8
LocusID (NCBI) 55336
Atlas_Id 63320
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 67159988 and ends at 67164174 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FBXL8 (16q22.1) / ALS2CL (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXL8   17875
Cards
Entrez_Gene (NCBI)FBXL8  55336  F-box and leucine rich repeat protein 8
AliasesFBL8
GeneCards (Weizmann)FBXL8
Ensembl hg19 (Hinxton)ENSG00000135722 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135722 [Gene_View]  chr16:67159988-67164174 [Contig_View]  FBXL8 [Vega]
ICGC DataPortalENSG00000135722
TCGA cBioPortalFBXL8
AceView (NCBI)FBXL8
Genatlas (Paris)FBXL8
WikiGenes55336
SOURCE (Princeton)FBXL8
Genetics Home Reference (NIH)FBXL8
Genomic and cartography
GoldenPath hg38 (UCSC)FBXL8  -     chr16:67159988-67164174 +  16q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXL8  -     16q22.1   [Description]    (hg19-Feb_2009)
EnsemblFBXL8 - 16q22.1 [CytoView hg19]  FBXL8 - 16q22.1 [CytoView hg38]
Mapping of homologs : NCBIFBXL8 [Mapview hg19]  FBXL8 [Mapview hg38]
OMIM609077   
Gene and transcription
Genbank (Entrez)AK002140 BC014414 DQ893665 DQ895774
RefSeq transcript (Entrez)NM_018378
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXL8
Cluster EST : UnigeneHs.710714 [ NCBI ]
CGAP (NCI)Hs.710714
Alternative Splicing GalleryENSG00000135722
Gene ExpressionFBXL8 [ NCBI-GEO ]   FBXL8 [ EBI - ARRAY_EXPRESS ]   FBXL8 [ SEEK ]   FBXL8 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55336
GTEX Portal (Tissue expression)FBXL8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96CD0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96CD0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96CD0
Splice isoforms : SwissVarQ96CD0
PhosPhoSitePlusQ96CD0
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    L_dom-like   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXL8
DMDM Disease mutations55336
Blocks (Seattle)FBXL8
SuperfamilyQ96CD0
Human Protein AtlasENSG00000135722
Peptide AtlasQ96CD0
HPRD16430
IPIIPI00161196   IPI00982594   IPI00973892   IPI00973809   IPI00981954   IPI00978381   IPI00979601   
Protein Interaction databases
DIP (DOE-UCLA)Q96CD0
IntAct (EBI)Q96CD0
FunCoupENSG00000135722
BioGRIDFBXL8
STRING (EMBL)FBXL8
ZODIACFBXL8
Ontologies - Pathways
QuickGOQ96CD0
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  
NDEx NetworkFBXL8
Atlas of Cancer Signalling NetworkFBXL8
Wikipedia pathwaysFBXL8
Orthology - Evolution
OrthoDB55336
GeneTree (enSembl)ENSG00000135722
Phylogenetic Trees/Animal Genes : TreeFamFBXL8
HOVERGENQ96CD0
HOGENOMQ96CD0
Homologs : HomoloGeneFBXL8
Homology/Alignments : Family Browser (UCSC)FBXL8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXL8
dbVarFBXL8
ClinVarFBXL8
1000_GenomesFBXL8 
Exome Variant ServerFBXL8
ExAC (Exome Aggregation Consortium)FBXL8 (select the gene name)
Genetic variants : HAPMAP55336
Genomic Variants (DGV)FBXL8 [DGVbeta]
DECIPHERFBXL8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXL8 
Mutations
ICGC Data PortalFBXL8 
TCGA Data PortalFBXL8 
Broad Tumor PortalFBXL8
OASIS PortalFBXL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXL8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXL8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXL8
DgiDB (Drug Gene Interaction Database)FBXL8
DoCM (Curated mutations)FBXL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXL8 (select a term)
intoGenFBXL8
Cancer3DFBXL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609077   
Orphanet
MedgenFBXL8
Genetic Testing Registry FBXL8
NextProtQ96CD0 [Medical]
TSGene55336
GENETestsFBXL8
Huge Navigator FBXL8 [HugePedia]
snp3D : Map Gene to Disease55336
BioCentury BCIQFBXL8
ClinGenFBXL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55336
Chemical/Pharm GKB GenePA28028
Clinical trialFBXL8
Miscellaneous
canSAR (ICR)FBXL8 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXL8
EVEXFBXL8
GoPubMedFBXL8
iHOPFBXL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:11:52 CEST 2017

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