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FBXO18 (F-box protein, helicase, 18)

Identity

Alias_namesF-box only protein 18
Alias_symbol (synonym)FBH1
FLJ14590
Fbx18
Other aliashFBH1
HGNC (Hugo) FBXO18
LocusID (NCBI) 84893
Atlas_Id 43054
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 5889572 and ends at 5937595 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCL6 (3q27.3) / FBXO18 (10p15.1)FBXO18 (10p15.1) / FBXO18 (10p15.1)FBXO18 (10p15.1) / FRMD4A (10p13)
FBXO18 (10p15.1) / ITGA8 (10p13)NCR1 (19q13.42) / FBXO18 (10p15.1)FBXO18 10p15.1 / FRMD4A 10p13
FBXO18 10p15.1 / ITGA8 10p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXO18   13620
Cards
Entrez_Gene (NCBI)FBXO18  84893  F-box protein, helicase, 18
AliasesFBH1; Fbx18; hFBH1
GeneCards (Weizmann)FBXO18
Ensembl hg19 (Hinxton)ENSG00000134452 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134452 [Gene_View]  chr10:5889572-5937595 [Contig_View]  FBXO18 [Vega]
ICGC DataPortalENSG00000134452
TCGA cBioPortalFBXO18
AceView (NCBI)FBXO18
Genatlas (Paris)FBXO18
WikiGenes84893
SOURCE (Princeton)FBXO18
Genetics Home Reference (NIH)FBXO18
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO18  -     chr10:5889572-5937595 +  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO18  -     10p15.1   [Description]    (hg19-Feb_2009)
EnsemblFBXO18 - 10p15.1 [CytoView hg19]  FBXO18 - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBIFBXO18 [Mapview hg19]  FBXO18 [Mapview hg38]
OMIM607222   
Gene and transcription
Genbank (Entrez)AF380349 AF454502 AF456237 AI818794 AK027381
RefSeq transcript (Entrez)NM_001258452 NM_001258453 NM_032807 NM_178150
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXO18
Cluster EST : UnigeneHs.498543 [ NCBI ]
CGAP (NCI)Hs.498543
Alternative Splicing GalleryENSG00000134452
Gene ExpressionFBXO18 [ NCBI-GEO ]   FBXO18 [ EBI - ARRAY_EXPRESS ]   FBXO18 [ SEEK ]   FBXO18 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84893
GTEX Portal (Tissue expression)FBXO18
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ0
Splice isoforms : SwissVarQ8NFZ0
PhosPhoSitePlusQ8NFZ0
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)DNA_helicase_UvrD-like_C    DNA_helicase_UvrD/REP    F-box_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)F-box-like (PF12937)    UvrD_C (PF13361)   
Domain families : Pfam (NCBI)pfam12937    pfam13361   
Conserved Domain (NCBI)FBXO18
DMDM Disease mutations84893
Blocks (Seattle)FBXO18
SuperfamilyQ8NFZ0
Human Protein AtlasENSG00000134452
Peptide AtlasQ8NFZ0
HPRD06243
IPIIPI00409721   IPI00375254   IPI00873232   IPI00641813   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ0
IntAct (EBI)Q8NFZ0
FunCoupENSG00000134452
BioGRIDFBXO18
STRING (EMBL)FBXO18
ZODIACFBXO18
Ontologies - Pathways
QuickGOQ8NFZ0
Ontology : AmiGOdouble-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  chromatin  positive regulation of protein phosphorylation  DNA helicase activity  DNA helicase activity  double-stranded DNA binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  cellular response to DNA damage stimulus  cell death  cell death  DNA translocase activity  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  replication fork processing  DNA duplex unwinding  negative regulation of chromatin binding  3'-5' DNA helicase activity  replication fork protection  response to intra-S DNA damage checkpoint signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of double-strand break repair via homologous recombination  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  DNA catabolic process, endonucleolytic  chromatin  positive regulation of protein phosphorylation  DNA helicase activity  DNA helicase activity  double-stranded DNA binding  single-stranded DNA binding  ATP-dependent DNA helicase activity  protein binding  ATP binding  nucleus  cellular response to DNA damage stimulus  cell death  cell death  DNA translocase activity  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  replication fork processing  DNA duplex unwinding  negative regulation of chromatin binding  3'-5' DNA helicase activity  replication fork protection  response to intra-S DNA damage checkpoint signaling  positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of double-strand break repair via homologous recombination  
NDEx NetworkFBXO18
Atlas of Cancer Signalling NetworkFBXO18
Wikipedia pathwaysFBXO18
Orthology - Evolution
OrthoDB84893
GeneTree (enSembl)ENSG00000134452
Phylogenetic Trees/Animal Genes : TreeFamFBXO18
HOVERGENQ8NFZ0
HOGENOMQ8NFZ0
Homologs : HomoloGeneFBXO18
Homology/Alignments : Family Browser (UCSC)FBXO18
Gene fusions - Rearrangements
Fusion : MitelmanBCL6/FBXO18 [3q27.3/10p15.1]  [t(3;10)(q27;p15)]  
Fusion : MitelmanFBXO18/FRMD4A [10p15.1/10p13]  [t(10;10)(p13;p15)]  
Fusion : MitelmanFBXO18/ITGA8 [10p15.1/10p13]  [t(10;10)(p13;p15)]  
Fusion: TCGAFBXO18 10p15.1 FRMD4A 10p13 PRAD
Fusion: TCGAFBXO18 10p15.1 ITGA8 10p13 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXO18
dbVarFBXO18
ClinVarFBXO18
1000_GenomesFBXO18 
Exome Variant ServerFBXO18
ExAC (Exome Aggregation Consortium)FBXO18 (select the gene name)
Genetic variants : HAPMAP84893
Genomic Variants (DGV)FBXO18 [DGVbeta]
DECIPHERFBXO18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO18 
Mutations
ICGC Data PortalFBXO18 
TCGA Data PortalFBXO18 
Broad Tumor PortalFBXO18
OASIS PortalFBXO18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXO18
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXO18
DgiDB (Drug Gene Interaction Database)FBXO18
DoCM (Curated mutations)FBXO18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXO18 (select a term)
intoGenFBXO18
Cancer3DFBXO18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607222   
Orphanet
MedgenFBXO18
Genetic Testing Registry FBXO18
NextProtQ8NFZ0 [Medical]
TSGene84893
GENETestsFBXO18
Huge Navigator FBXO18 [HugePedia]
snp3D : Map Gene to Disease84893
BioCentury BCIQFBXO18
ClinGenFBXO18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84893
Chemical/Pharm GKB GenePA134948258
Clinical trialFBXO18
Miscellaneous
canSAR (ICR)FBXO18 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXO18
EVEXFBXO18
GoPubMedFBXO18
iHOPFBXO18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:15:39 CEST 2017

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