Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXO2 (F-box protein 2)

Identity

Alias_namesOCP1
F-box only protein 2
organ of Corti protein 1
Alias_symbol (synonym)FBX2
Nfb42
Fbs1
Fbg1
Other aliasFBG1
NFB42
HGNC (Hugo) FBXO2
LocusID (NCBI) 26232
Atlas_Id 56334
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 11648361 and ends at 11654831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP15 (2q22.2) / FBXO2 (1p36.22)LOC100507412 (-) / FBXO2 (1p36.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXO2   13581
Cards
Entrez_Gene (NCBI)FBXO2  26232  F-box protein 2
AliasesFBG1; FBX2; Fbs1; NFB42; 
OCP1
GeneCards (Weizmann)FBXO2
Ensembl hg19 (Hinxton)ENSG00000116661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116661 [Gene_View]  ENSG00000116661 [Sequence]  chr1:11648361-11654831 [Contig_View]  FBXO2 [Vega]
ICGC DataPortalENSG00000116661
TCGA cBioPortalFBXO2
AceView (NCBI)FBXO2
Genatlas (Paris)FBXO2
WikiGenes26232
SOURCE (Princeton)FBXO2
Genetics Home Reference (NIH)FBXO2
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO2  -     chr1:11648361-11654831 -  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO2  -     1p36.22   [Description]    (hg19-Feb_2009)
EnsemblFBXO2 - 1p36.22 [CytoView hg19]  FBXO2 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBIFBXO2 [Mapview hg19]  FBXO2 [Mapview hg38]
OMIM607112   
Gene and transcription
Genbank (Entrez)AF174594 AF187318 AK308531 AK313019 AW138262
RefSeq transcript (Entrez)NM_012168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXO2
Cluster EST : UnigeneHs.556006 [ NCBI ]
CGAP (NCI)Hs.556006
Alternative Splicing GalleryENSG00000116661
Gene ExpressionFBXO2 [ NCBI-GEO ]   FBXO2 [ EBI - ARRAY_EXPRESS ]   FBXO2 [ SEEK ]   FBXO2 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26232
GTEX Portal (Tissue expression)FBXO2
Human Protein AtlasENSG00000116661-FBXO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UK22   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UK22  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UK22
Splice isoforms : SwissVarQ9UK22
PhosPhoSitePlusQ9UK22
Domaine pattern : Prosite (Expaxy)FBA (PS51114)    FBOX (PS50181)   
Domains : Interpro (EBI)F-box-assoc_dom    F-box_dom    Galactose-bd-like   
Domain families : Pfam (Sanger)F-box (PF00646)    FBA (PF04300)   
Domain families : Pfam (NCBI)pfam00646    pfam04300   
Domain families : Smart (EMBL)FBA (SM01198)  
Conserved Domain (NCBI)FBXO2
DMDM Disease mutations26232
Blocks (Seattle)FBXO2
SuperfamilyQ9UK22
Human Protein Atlas [tissue]ENSG00000116661-FBXO2 [tissue]
Peptide AtlasQ9UK22
HPRD06171
IPIIPI01018924   IPI00844514   IPI00941983   
Protein Interaction databases
DIP (DOE-UCLA)Q9UK22
IntAct (EBI)Q9UK22
FunCoupENSG00000116661
BioGRIDFBXO2
STRING (EMBL)FBXO2
ZODIACFBXO2
Ontologies - Pathways
QuickGOQ9UK22
Ontology : AmiGOprotein polyubiquitination  amyloid-beta binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  cellular protein modification process  proteolysis  glycoprotein catabolic process  negative regulation of cell proliferation  protein ubiquitination  SCF ubiquitin ligase complex  carbohydrate binding  ubiquitin-dependent ERAD pathway  organelle membrane  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  regulation of protein ubiquitination  dendritic spine  post-translational protein modification  extracellular exosome  
Ontology : EGO-EBIprotein polyubiquitination  amyloid-beta binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  cellular protein modification process  proteolysis  glycoprotein catabolic process  negative regulation of cell proliferation  protein ubiquitination  SCF ubiquitin ligase complex  carbohydrate binding  ubiquitin-dependent ERAD pathway  organelle membrane  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  regulation of protein ubiquitination  dendritic spine  post-translational protein modification  extracellular exosome  
Pathways : BIOCARTAER┐associated degradation (ERAD) Pathway [Genes]   
NDEx NetworkFBXO2
Atlas of Cancer Signalling NetworkFBXO2
Wikipedia pathwaysFBXO2
Orthology - Evolution
OrthoDB26232
GeneTree (enSembl)ENSG00000116661
Phylogenetic Trees/Animal Genes : TreeFamFBXO2
HOVERGENQ9UK22
HOGENOMQ9UK22
Homologs : HomoloGeneFBXO2
Homology/Alignments : Family Browser (UCSC)FBXO2
Gene fusions - Rearrangements
Fusion : QuiverFBXO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXO2
dbVarFBXO2
ClinVarFBXO2
1000_GenomesFBXO2 
Exome Variant ServerFBXO2
ExAC (Exome Aggregation Consortium)ENSG00000116661
GNOMAD BrowserENSG00000116661
Genetic variants : HAPMAP26232
Genomic Variants (DGV)FBXO2 [DGVbeta]
DECIPHERFBXO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO2 
Mutations
ICGC Data PortalFBXO2 
TCGA Data PortalFBXO2 
Broad Tumor PortalFBXO2
OASIS PortalFBXO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXO2
DgiDB (Drug Gene Interaction Database)FBXO2
DoCM (Curated mutations)FBXO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXO2 (select a term)
intoGenFBXO2
Cancer3DFBXO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607112   
Orphanet
DisGeNETFBXO2
MedgenFBXO2
Genetic Testing Registry FBXO2
NextProtQ9UK22 [Medical]
TSGene26232
GENETestsFBXO2
Target ValidationFBXO2
Huge Navigator FBXO2 [HugePedia]
snp3D : Map Gene to Disease26232
BioCentury BCIQFBXO2
ClinGenFBXO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26232
Chemical/Pharm GKB GenePA31895
Clinical trialFBXO2
Miscellaneous
canSAR (ICR)FBXO2 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXO2
EVEXFBXO2
GoPubMedFBXO2
iHOPFBXO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:25:23 CEST 2018

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