FBXO4 (F-box protein 4)

2008-09-01 Affiliation

Identity

HGNC

FBXO4

LOCATION

5p13.1

LOCUSID

26272

ALIAS

FBX4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 26272
MIM: 609090
HGNC: 13583
Ensembl: ENSG00000151876

Variants:

dbSNP: 26272
ClinVar: 26272
TCGA: ENSG00000151876
COSMIC: FBXO4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151876	ENST00000281623	Q9UKT5
ENSG00000151876	ENST00000296812	Q9UKT5
ENSG00000151876	ENST00000504463	D6REP2
ENSG00000151876	ENST00000509134	D6RAJ6
ENSG00000151876	ENST00000513496	D6RAU6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Ubiquitin mediated proteolysis	KEGG	ko04120
Ubiquitin mediated proteolysis	KEGG	hsa04120
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Association of TriC/CCT with target proteins during biosynthesis	REACTOME	R-HSA-390471
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

References

Pubmed ID	Year	Title	Citations
17081987	2006	Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex.	152
18598945	2008	Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.	71
16275645	2006	The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance.	50
20159592	2010	Structural basis of selective ubiquitination of TRF1 by SCFFbx4.	26
24019069	2013	The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma.	15
20181953	2010	Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.	14
21242966	2011	Phosphorylation-dependent regulation of SCF(Fbx4) dimerization and activity involves a novel component, 14-3-3ɛ.	13
29142209	2017	Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.	10
24704453	2014	Alternative splicing variants of human Fbx4 disturb cyclin D1 proteolysis in human cancer.	6
28776569	2017	FBXO4 inhibits lung cancer cell survival by targeting Mcl-1 for degradation.	6

Citation

Dessen P

FBXO4 (F-box protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50376/fbxo4