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FBXO4 (F-box protein 4)

Identity

Alias (NCBI)FBX4
HGNC (Hugo) FBXO4
HGNC Alias symbFBX4
HGNC Previous nameF-box only protein 4
LocusID (NCBI) 26272
Atlas_Id 50376
Location 5p13.1  [Link to chromosome band 5p13]
Location_base_pair Starts at 41925254 and ends at 41935083 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP210 (3p25.1)::FBXO4 (5p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FBXO4   13583
Cards
Entrez_Gene (NCBI)FBXO4    F-box protein 4
AliasesFBX4
GeneCards (Weizmann)FBXO4
Ensembl hg19 (Hinxton)ENSG00000151876 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151876 [Gene_View]  ENSG00000151876 [Sequence]  chr5:41925254-41935083 [Contig_View]  FBXO4 [Vega]
ICGC DataPortalENSG00000151876
TCGA cBioPortalFBXO4
AceView (NCBI)FBXO4
Genatlas (Paris)FBXO4
SOURCE (Princeton)FBXO4
Genetics Home Reference (NIH)FBXO4
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO4  -     chr5:41925254-41935083 +  5p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO4  -     5p13.1   [Description]    (hg19-Feb_2009)
GoldenPathFBXO4 - 5p13.1 [CytoView hg19]  FBXO4 - 5p13.1 [CytoView hg38]
ImmunoBaseENSG00000151876
Genome Data Viewer NCBIFBXO4 [Mapview hg19]  
OMIM609090   
Gene and transcription
Genbank (Entrez)AF129534 AF176703 AK001003 AK024075 AU143782
RefSeq transcript (Entrez)NM_001297437 NM_012176 NM_033484
Consensus coding sequences : CCDS (NCBI)FBXO4
Gene ExpressionFBXO4 [ NCBI-GEO ]   FBXO4 [ EBI - ARRAY_EXPRESS ]   FBXO4 [ SEEK ]   FBXO4 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO4 [ Firebrowse - Broad ]
GenevisibleExpression of FBXO4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26272
GTEX Portal (Tissue expression)FBXO4
Human Protein AtlasENSG00000151876-FBXO4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKT5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKT5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKT5
PhosPhoSitePlusQ9UKT5
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box-like_dom_sf    F-box_dom    FBXO4   
Domain families : Pfam (Sanger)F-box (PF00646)   
Domain families : Pfam (NCBI)pfam00646   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXO4
PDB (RSDB)3L2O    3L82   
PDB Europe3L2O    3L82   
PDB (PDBSum)3L2O    3L82   
PDB (IMB)3L2O    3L82   
Structural Biology KnowledgeBase3L2O    3L82   
SCOP (Structural Classification of Proteins)3L2O    3L82   
CATH (Classification of proteins structures)3L2O    3L82   
SuperfamilyQ9UKT5
AlphaFold pdb e-kbQ9UKT5   
Human Protein Atlas [tissue]ENSG00000151876-FBXO4 [tissue]
HPRD09949
Protein Interaction databases
DIP (DOE-UCLA)Q9UKT5
IntAct (EBI)Q9UKT5
BioGRIDFBXO4
STRING (EMBL)FBXO4
ZODIACFBXO4
Ontologies - Pathways
QuickGOQ9UKT5
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  aging  posttranscriptional regulation of gene expression  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  cellular homeostasis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  regulation of protein stability  regulation of protein stability  protein destabilization  positive regulation of telomere maintenance via telomerase  positive regulation of telomere maintenance via telomerase  common myeloid progenitor cell proliferation  protein homodimerization activity  negative regulation of fibroblast proliferation  ubiquitin protein ligase activity  cellular response to ionizing radiation  negative regulation of protein localization to nucleus  positive regulation of protein polyubiquitination  regulation of DNA damage checkpoint  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  ubiquitin-protein transferase activity  protein binding  cytoplasm  cytosol  aging  posttranscriptional regulation of gene expression  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  cellular homeostasis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  regulation of protein stability  regulation of protein stability  protein destabilization  positive regulation of telomere maintenance via telomerase  positive regulation of telomere maintenance via telomerase  common myeloid progenitor cell proliferation  protein homodimerization activity  negative regulation of fibroblast proliferation  ubiquitin protein ligase activity  cellular response to ionizing radiation  negative regulation of protein localization to nucleus  positive regulation of protein polyubiquitination  regulation of DNA damage checkpoint  
Pathways : KEGGKEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS   
NDEx NetworkFBXO4
Atlas of Cancer Signalling NetworkFBXO4
Wikipedia pathwaysFBXO4
Orthology - Evolution
OrthoDB26272
GeneTree (enSembl)ENSG00000151876
Phylogenetic Trees/Animal Genes : TreeFamFBXO4
Homologs : HomoloGeneFBXO4
Homology/Alignments : Family Browser (UCSC)FBXO4
Gene fusions - Rearrangements
Fusion : QuiverFBXO4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXO4
dbVarFBXO4
ClinVarFBXO4
MonarchFBXO4
1000_GenomesFBXO4 
Exome Variant ServerFBXO4
GNOMAD BrowserENSG00000151876
Varsome BrowserFBXO4
ACMGFBXO4 variants
VarityQ9UKT5
Genomic Variants (DGV)FBXO4 [DGVbeta]
DECIPHERFBXO4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO4 
Mutations
ICGC Data PortalFBXO4 
TCGA Data PortalFBXO4 
Broad Tumor PortalFBXO4
OASIS PortalFBXO4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFBXO4
Mutations and Diseases : HGMDFBXO4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFBXO4
DgiDB (Drug Gene Interaction Database)FBXO4
DoCM (Curated mutations)FBXO4
CIViC (Clinical Interpretations of Variants in Cancer)FBXO4
Cancer3DFBXO4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609090   
Orphanet
DisGeNETFBXO4
MedgenFBXO4
Genetic Testing Registry FBXO4
NextProtQ9UKT5 [Medical]
GENETestsFBXO4
Target ValidationFBXO4
Huge Navigator FBXO4 [HugePedia]
ClinGenFBXO4
Clinical trials, drugs, therapy
MyCancerGenomeFBXO4
Protein Interactions : CTDFBXO4
Pharm GKB GenePA28044
PharosQ9UKT5
Clinical trialFBXO4
Miscellaneous
canSAR (ICR)FBXO4
HarmonizomeFBXO4
ARCHS4FBXO4
DataMed IndexFBXO4
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFBXO4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:33:18 CET 2022

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