Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXO5 (F-box protein 5)

Identity

Alias_namesF-box only protein 5
Alias_symbol (synonym)FBX5
Fbxo31
EMI1
Other alias
HGNC (Hugo) FBXO5
LocusID (NCBI) 26271
Atlas_Id 50287
Location 6q25.2  [Link to chromosome band 6q25]
Location_base_pair Starts at 152970519 and ends at 152983082 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXO5   13584
Cards
Entrez_Gene (NCBI)FBXO5  26271  F-box protein 5
AliasesEMI1; FBX5; Fbxo31
GeneCards (Weizmann)FBXO5
Ensembl hg19 (Hinxton)ENSG00000112029 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112029 [Gene_View]  ENSG00000112029 [Sequence]  chr6:152970519-152983082 [Contig_View]  FBXO5 [Vega]
ICGC DataPortalENSG00000112029
TCGA cBioPortalFBXO5
AceView (NCBI)FBXO5
Genatlas (Paris)FBXO5
WikiGenes26271
SOURCE (Princeton)FBXO5
Genetics Home Reference (NIH)FBXO5
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO5  -     chr6:152970519-152983082 -  6q25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO5  -     6q25.2   [Description]    (hg19-Feb_2009)
EnsemblFBXO5 - 6q25.2 [CytoView hg19]  FBXO5 - 6q25.2 [CytoView hg38]
Mapping of homologs : NCBIFBXO5 [Mapview hg19]  FBXO5 [Mapview hg38]
OMIM606013   
Gene and transcription
Genbank (Entrez)AF129535 AI769650 AJ420499 AK026197 AK055221
RefSeq transcript (Entrez)NM_001142522 NM_012177
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXO5
Cluster EST : UnigeneHs.713801 [ NCBI ]
CGAP (NCI)Hs.713801
Alternative Splicing GalleryENSG00000112029
Gene ExpressionFBXO5 [ NCBI-GEO ]   FBXO5 [ EBI - ARRAY_EXPRESS ]   FBXO5 [ SEEK ]   FBXO5 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26271
GTEX Portal (Tissue expression)FBXO5
Human Protein AtlasENSG00000112029-FBXO5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKT4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKT4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKT4
Splice isoforms : SwissVarQ9UKT4
PhosPhoSitePlusQ9UKT4
Domains : Interpro (EBI)F-box_dom   
Domain families : Pfam (Sanger)F-box (PF00646)   
Domain families : Pfam (NCBI)pfam00646   
Conserved Domain (NCBI)FBXO5
DMDM Disease mutations26271
Blocks (Seattle)FBXO5
PDB (SRS)2M6N    4UI9   
PDB (PDBSum)2M6N    4UI9   
PDB (IMB)2M6N    4UI9   
PDB (RSDB)2M6N    4UI9   
Structural Biology KnowledgeBase2M6N    4UI9   
SCOP (Structural Classification of Proteins)2M6N    4UI9   
CATH (Classification of proteins structures)2M6N    4UI9   
SuperfamilyQ9UKT4
Human Protein Atlas [tissue]ENSG00000112029-FBXO5 [tissue]
Peptide AtlasQ9UKT4
HPRD09348
IPIIPI00016633   IPI00645436   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKT4
IntAct (EBI)Q9UKT4
FunCoupENSG00000112029
BioGRIDFBXO5
STRING (EMBL)FBXO5
ZODIACFBXO5
Ontologies - Pathways
QuickGOQ9UKT4
Ontology : AmiGOregulation of transcription involved in G1/S transition of mitotic cell cycle  oocyte maturation  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  spindle  cytosol  regulation of DNA replication  spindle assembly involved in female meiosis I  regulation of mitotic cell cycle  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  anaphase-promoting complex binding  vesicle organization  protein kinase binding  anaphase-promoting complex-dependent catabolic process  negative regulation of DNA endoreduplication  positive regulation of osteoblast differentiation  negative regulation of meiotic nuclear division  negative regulation of mitotic metaphase/anaphase transition  microtubule polymerization  metal ion binding  cell division  negative regulation of ubiquitin-protein transferase activity  positive regulation of biomineral tissue development  meiotic spindle  negative regulation of ubiquitin protein ligase activity  negative regulation of ubiquitin protein ligase activity  positive regulation of mesenchymal stem cell migration  ubiquitin ligase inhibitor activity  negative regulation of cellular senescence  negative regulation of response to DNA damage stimulus  
Ontology : EGO-EBIregulation of transcription involved in G1/S transition of mitotic cell cycle  oocyte maturation  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  spindle  cytosol  regulation of DNA replication  spindle assembly involved in female meiosis I  regulation of mitotic cell cycle  positive regulation of cell proliferation  positive regulation of G2/M transition of mitotic cell cycle  anaphase-promoting complex binding  vesicle organization  protein kinase binding  anaphase-promoting complex-dependent catabolic process  negative regulation of DNA endoreduplication  positive regulation of osteoblast differentiation  negative regulation of meiotic nuclear division  negative regulation of mitotic metaphase/anaphase transition  microtubule polymerization  metal ion binding  cell division  negative regulation of ubiquitin-protein transferase activity  positive regulation of biomineral tissue development  meiotic spindle  negative regulation of ubiquitin protein ligase activity  negative regulation of ubiquitin protein ligase activity  positive regulation of mesenchymal stem cell migration  ubiquitin ligase inhibitor activity  negative regulation of cellular senescence  negative regulation of response to DNA damage stimulus  
Pathways : KEGGOocyte meiosis   
NDEx NetworkFBXO5
Atlas of Cancer Signalling NetworkFBXO5
Wikipedia pathwaysFBXO5
Orthology - Evolution
OrthoDB26271
GeneTree (enSembl)ENSG00000112029
Phylogenetic Trees/Animal Genes : TreeFamFBXO5
HOVERGENQ9UKT4
HOGENOMQ9UKT4
Homologs : HomoloGeneFBXO5
Homology/Alignments : Family Browser (UCSC)FBXO5
Gene fusions - Rearrangements
Fusion : QuiverFBXO5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXO5
dbVarFBXO5
ClinVarFBXO5
1000_GenomesFBXO5 
Exome Variant ServerFBXO5
ExAC (Exome Aggregation Consortium)ENSG00000112029
GNOMAD BrowserENSG00000112029
Varsome BrowserFBXO5
Genetic variants : HAPMAP26271
Genomic Variants (DGV)FBXO5 [DGVbeta]
DECIPHERFBXO5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO5 
Mutations
ICGC Data PortalFBXO5 
TCGA Data PortalFBXO5 
Broad Tumor PortalFBXO5
OASIS PortalFBXO5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXO5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXO5
DgiDB (Drug Gene Interaction Database)FBXO5
DoCM (Curated mutations)FBXO5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXO5 (select a term)
intoGenFBXO5
Cancer3DFBXO5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606013   
Orphanet
DisGeNETFBXO5
MedgenFBXO5
Genetic Testing Registry FBXO5
NextProtQ9UKT4 [Medical]
TSGene26271
GENETestsFBXO5
Target ValidationFBXO5
Huge Navigator FBXO5 [HugePedia]
snp3D : Map Gene to Disease26271
BioCentury BCIQFBXO5
ClinGenFBXO5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26271
Chemical/Pharm GKB GenePA28045
Clinical trialFBXO5
Miscellaneous
canSAR (ICR)FBXO5 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXO5
EVEXFBXO5
GoPubMedFBXO5
iHOPFBXO5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:06:09 CET 2018

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