Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FBXO7 (F-box protein 7)

Identity

Alias_namesF-box only protein 7
Alias_symbol (synonym)FBX7
Fbx
PARK15
Other aliasFBX
FBX07
PKPS
HGNC (Hugo) FBXO7
LocusID (NCBI) 25793
Atlas_Id 55738
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 32474720 and ends at 32498831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXO7 (22q12.3) / CCT8 (21q21.3)FBXO7 (22q12.3) / FBXO7 (22q12.3)FBXO7 (22q12.3) / LGI3 (8p21.3)
MOG (6p22.1) / FBXO7 (22q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FBXO7   13586
Cards
Entrez_Gene (NCBI)FBXO7  25793  F-box protein 7
AliasesFBX; FBX07; FBX7; PARK15; 
PKPS
GeneCards (Weizmann)FBXO7
Ensembl hg19 (Hinxton)ENSG00000100225 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100225 [Gene_View]  ENSG00000100225 [Sequence]  chr22:32474720-32498831 [Contig_View]  FBXO7 [Vega]
ICGC DataPortalENSG00000100225
TCGA cBioPortalFBXO7
AceView (NCBI)FBXO7
Genatlas (Paris)FBXO7
WikiGenes25793
SOURCE (Princeton)FBXO7
Genetics Home Reference (NIH)FBXO7
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO7  -     chr22:32474720-32498831 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO7  -     22q12.3   [Description]    (hg19-Feb_2009)
EnsemblFBXO7 - 22q12.3 [CytoView hg19]  FBXO7 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBIFBXO7 [Mapview hg19]  FBXO7 [Mapview hg38]
OMIM260300   605648   
Gene and transcription
Genbank (Entrez)AF129537 AF233225 AK054739 AK226087 AK291972
RefSeq transcript (Entrez)NM_001033024 NM_001257990 NM_012179
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXO7
Cluster EST : UnigeneHs.5912 [ NCBI ]
CGAP (NCI)Hs.5912
Alternative Splicing GalleryENSG00000100225
Gene ExpressionFBXO7 [ NCBI-GEO ]   FBXO7 [ EBI - ARRAY_EXPRESS ]   FBXO7 [ SEEK ]   FBXO7 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25793
GTEX Portal (Tissue expression)FBXO7
Human Protein AtlasENSG00000100225-FBXO7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3I1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3I1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3I1
Splice isoforms : SwissVarQ9Y3I1
PhosPhoSitePlusQ9Y3I1
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    PI31_Prot_N    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)    PI31_Prot_N (PF11566)   
Domain families : Pfam (NCBI)pfam12937    pfam11566   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXO7
DMDM Disease mutations25793
Blocks (Seattle)FBXO7
PDB (SRS)4L9C    4L9H   
PDB (PDBSum)4L9C    4L9H   
PDB (IMB)4L9C    4L9H   
PDB (RSDB)4L9C    4L9H   
Structural Biology KnowledgeBase4L9C    4L9H   
SCOP (Structural Classification of Proteins)4L9C    4L9H   
CATH (Classification of proteins structures)4L9C    4L9H   
SuperfamilyQ9Y3I1
Human Protein Atlas [tissue]ENSG00000100225-FBXO7 [tissue]
Peptide AtlasQ9Y3I1
HPRD07292
IPIIPI00294567   IPI00853513   IPI00651672   IPI00852672   IPI00879860   IPI00880012   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3I1
IntAct (EBI)Q9Y3I1
FunCoupENSG00000100225
BioGRIDFBXO7
STRING (EMBL)FBXO7
ZODIACFBXO7
Ontologies - Pathways
QuickGOQ9Y3I1
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  autophagy of mitochondrion  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein targeting to mitochondrion  regulation of neuron projection development  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  protein kinase binding  ubiquitin protein ligase binding  regulation of protein stability  regulation of locomotion  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin binding  protein complex  post-translational protein modification  negative regulation of lymphocyte differentiation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  protein heterodimerization activity  glial cytoplasmic inclusion  classical Lewy body  Lewy neurite  negative regulation of oxidative stress-induced neuron death  positive regulation of autophagy of mitochondrion  Lewy body core  Lewy body corona  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  autophagy of mitochondrion  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein targeting to mitochondrion  regulation of neuron projection development  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  protein kinase binding  ubiquitin protein ligase binding  regulation of protein stability  regulation of locomotion  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  ubiquitin binding  protein complex  post-translational protein modification  negative regulation of lymphocyte differentiation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  protein heterodimerization activity  glial cytoplasmic inclusion  classical Lewy body  Lewy neurite  negative regulation of oxidative stress-induced neuron death  positive regulation of autophagy of mitochondrion  Lewy body core  Lewy body corona  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkFBXO7
Atlas of Cancer Signalling NetworkFBXO7
Wikipedia pathwaysFBXO7
Orthology - Evolution
OrthoDB25793
GeneTree (enSembl)ENSG00000100225
Phylogenetic Trees/Animal Genes : TreeFamFBXO7
HOVERGENQ9Y3I1
HOGENOMQ9Y3I1
Homologs : HomoloGeneFBXO7
Homology/Alignments : Family Browser (UCSC)FBXO7
Gene fusions - Rearrangements
Fusion : QuiverFBXO7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXO7
dbVarFBXO7
ClinVarFBXO7
1000_GenomesFBXO7 
Exome Variant ServerFBXO7
ExAC (Exome Aggregation Consortium)ENSG00000100225
GNOMAD BrowserENSG00000100225
Genetic variants : HAPMAP25793
Genomic Variants (DGV)FBXO7 [DGVbeta]
DECIPHERFBXO7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO7 
Mutations
ICGC Data PortalFBXO7 
TCGA Data PortalFBXO7 
Broad Tumor PortalFBXO7
OASIS PortalFBXO7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXO7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXO7
DgiDB (Drug Gene Interaction Database)FBXO7
DoCM (Curated mutations)FBXO7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXO7 (select a term)
intoGenFBXO7
Cancer3DFBXO7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260300    605648   
Orphanet17928   
DisGeNETFBXO7
MedgenFBXO7
Genetic Testing Registry FBXO7
NextProtQ9Y3I1 [Medical]
TSGene25793
GENETestsFBXO7
Target ValidationFBXO7
Huge Navigator FBXO7 [HugePedia]
snp3D : Map Gene to Disease25793
BioCentury BCIQFBXO7
ClinGenFBXO7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25793
Chemical/Pharm GKB GenePA28047
Clinical trialFBXO7
Miscellaneous
canSAR (ICR)FBXO7 (select the gene name)
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXO7
EVEXFBXO7
GoPubMedFBXO7
iHOPFBXO7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:25:28 CEST 2018
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