Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FBXO7 (F-box protein 7)

Identity

Alias (NCBI)FBX
FBX07
FBX7
PARK15
PKPS
HGNC (Hugo) FBXO7
HGNC Alias symbFBX7
Fbx
PARK15
HGNC Previous nameF-box only protein 7
LocusID (NCBI) 25793
Atlas_Id 55738
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 32474811 and ends at 32498829 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXO7 (22q12.3) / CCT8 (21q21.3)FBXO7 (22q12.3) / FBXO7 (22q12.3)FBXO7 (22q12.3) / LGI3 (8p21.3)
MOG (6p22.1) / FBXO7 (22q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FBXO7   13586
Cards
Entrez_Gene (NCBI)FBXO7    F-box protein 7
AliasesFBX; FBX07; FBX7; PARK15; 
PKPS
GeneCards (Weizmann)FBXO7
Ensembl hg19 (Hinxton)ENSG00000100225 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100225 [Gene_View]  ENSG00000100225 [Sequence]  chr22:32474811-32498829 [Contig_View]  FBXO7 [Vega]
ICGC DataPortalENSG00000100225
TCGA cBioPortalFBXO7
AceView (NCBI)FBXO7
Genatlas (Paris)FBXO7
SOURCE (Princeton)FBXO7
Genetics Home Reference (NIH)FBXO7
Genomic and cartography
GoldenPath hg38 (UCSC)FBXO7  -     chr22:32474811-32498829 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXO7  -     22q12.3   [Description]    (hg19-Feb_2009)
GoldenPathFBXO7 - 22q12.3 [CytoView hg19]  FBXO7 - 22q12.3 [CytoView hg38]
ImmunoBaseENSG00000100225
genome Data Viewer NCBIFBXO7 [Mapview hg19]  
OMIM260300   605648   
Gene and transcription
Genbank (Entrez)AF129537 AF233225 AK054739 AK226087 AK291972
RefSeq transcript (Entrez)NM_001033024 NM_001257990 NM_012179
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXO7
Alternative Splicing GalleryENSG00000100225
Gene ExpressionFBXO7 [ NCBI-GEO ]   FBXO7 [ EBI - ARRAY_EXPRESS ]   FBXO7 [ SEEK ]   FBXO7 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXO7 [ Firebrowse - Broad ]
GenevisibleExpression of FBXO7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25793
GTEX Portal (Tissue expression)FBXO7
Human Protein AtlasENSG00000100225-FBXO7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3I1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3I1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3I1
Splice isoforms : SwissVarQ9Y3I1
PhosPhoSitePlusQ9Y3I1
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box-like_dom_sf    F-box_dom    PI31_Prot_N    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)F-box-like (PF12937)    PI31_Prot_N (PF11566)   
Domain families : Pfam (NCBI)pfam12937    pfam11566   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXO7
Blocks (Seattle)FBXO7
PDB (RSDB)4L9C    4L9H   
PDB Europe4L9C    4L9H   
PDB (PDBSum)4L9C    4L9H   
PDB (IMB)4L9C    4L9H   
Structural Biology KnowledgeBase4L9C    4L9H   
SCOP (Structural Classification of Proteins)4L9C    4L9H   
CATH (Classification of proteins structures)4L9C    4L9H   
SuperfamilyQ9Y3I1
Human Protein Atlas [tissue]ENSG00000100225-FBXO7 [tissue]
Peptide AtlasQ9Y3I1
HPRD07292
IPIIPI00294567   IPI00853513   IPI00651672   IPI00852672   IPI00879860   IPI00880012   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3I1
IntAct (EBI)Q9Y3I1
BioGRIDFBXO7
STRING (EMBL)FBXO7
ZODIACFBXO7
Ontologies - Pathways
QuickGOQ9Y3I1
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  autophagy of mitochondrion  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein targeting to mitochondrion  regulation of neuron projection development  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  protein kinase binding  protein kinase binding  ubiquitin protein ligase binding  regulation of protein stability  protein-containing complex  regulation of locomotion  ubiquitin binding  post-translational protein modification  negative regulation of lymphocyte differentiation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  protein heterodimerization activity  glial cytoplasmic inclusion  classical Lewy body  Lewy neurite  negative regulation of oxidative stress-induced neuron death  negative regulation of oxidative stress-induced neuron death  positive regulation of autophagy of mitochondrion  positive regulation of autophagy of mitochondrion  Lewy body core  Lewy body corona  protein binding, bridging involved in substrate recognition for ubiquitination  negative regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  autophagy of mitochondrion  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytoplasm  mitochondrion  cytosol  cytosol  ubiquitin-dependent protein catabolic process  protein targeting to mitochondrion  regulation of neuron projection development  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF ubiquitin ligase complex  protein kinase binding  protein kinase binding  ubiquitin protein ligase binding  regulation of protein stability  protein-containing complex  regulation of locomotion  ubiquitin binding  post-translational protein modification  negative regulation of lymphocyte differentiation  negative regulation of cyclin-dependent protein serine/threonine kinase activity  protein heterodimerization activity  glial cytoplasmic inclusion  classical Lewy body  Lewy neurite  negative regulation of oxidative stress-induced neuron death  negative regulation of oxidative stress-induced neuron death  positive regulation of autophagy of mitochondrion  positive regulation of autophagy of mitochondrion  Lewy body core  Lewy body corona  protein binding, bridging involved in substrate recognition for ubiquitination  negative regulation of G1/S transition of mitotic cell cycle  
NDEx NetworkFBXO7
Atlas of Cancer Signalling NetworkFBXO7
Wikipedia pathwaysFBXO7
Orthology - Evolution
OrthoDB25793
GeneTree (enSembl)ENSG00000100225
Phylogenetic Trees/Animal Genes : TreeFamFBXO7
HOGENOMQ9Y3I1
Homologs : HomoloGeneFBXO7
Homology/Alignments : Family Browser (UCSC)FBXO7
Gene fusions - Rearrangements
Fusion : QuiverFBXO7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXO7 [hg38]
dbVarFBXO7
ClinVarFBXO7
MonarchFBXO7
1000_GenomesFBXO7 
Exome Variant ServerFBXO7
GNOMAD BrowserENSG00000100225
Varsome BrowserFBXO7
Genomic Variants (DGV)FBXO7 [DGVbeta]
DECIPHERFBXO7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXO7 
Mutations
ICGC Data PortalFBXO7 
TCGA Data PortalFBXO7 
Broad Tumor PortalFBXO7
OASIS PortalFBXO7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXO7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFBXO7
Mutations and Diseases : HGMDFBXO7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXO7
DgiDB (Drug Gene Interaction Database)FBXO7
DoCM (Curated mutations)FBXO7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXO7 (select a term)
intoGenFBXO7
Cancer3DFBXO7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260300    605648   
Orphanet17928   
DisGeNETFBXO7
MedgenFBXO7
Genetic Testing Registry FBXO7
NextProtQ9Y3I1 [Medical]
GENETestsFBXO7
Target ValidationFBXO7
Huge Navigator FBXO7 [HugePedia]
ClinGenFBXO7
Clinical trials, drugs, therapy
MyCancerGenomeFBXO7
Protein Interactions : CTD
Pharm GKB GenePA28047
PharosQ9Y3I1
Clinical trialFBXO7
Miscellaneous
canSAR (ICR)FBXO7 (select the gene name)
HarmonizomeFBXO7
DataMed IndexFBXO7
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFBXO7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:15:27 CET 2021
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