FBXW10 (F-box and WD repeat domain containing 10)

2014-11-01  

Identity

HGNC
FBXW10
LOCATION
17p11.2
LOCUSID
10517
ALIAS
Fbw10,HREP,SM25H2,SM2SH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10517
MIM: 611679
HGNC: 1211
Ensembl: ENSG00000171931

Variants:

dbSNP: 10517
ClinVar: 10517
TCGA: ENSG00000171931
COSMIC: FBXW10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171931ENST00000301938Q5XX13
ENSG00000171931ENST00000308799Q5XX13
ENSG00000171931ENST00000395665Q5XX13
ENSG00000171931ENST00000574478J3QLH9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
204987032010Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.12
238995202013FBXW10 is negatively regulated in transcription and expression level by protein O-GlcNAcylation.4

Citation

Dessen P

FBXW10 (F-box and WD repeat domain containing 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63338/fbxw10