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FBXW11 (F-box and WD repeat domain containing 11)

Identity

Alias_namesFBXW1B
F-box and WD-40 domain protein 1B
F-box and WD-40 domain protein 11
Alias_symbol (synonym)KIAA0696
Fbw1b
BTRCP2
BTRC2
Hos
Fbw11
Other aliasFBW1B
HGNC (Hugo) FBXW11
LocusID (NCBI) 23291
Atlas_Id 55423
Location 5q35.1  [Link to chromosome band 5q35]
Location_base_pair Starts at 171861552 and ends at 172006873 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBXW11 (5q35.1) / NPM1 (5q35.1)THBS3 (1q22) / FBXW11 (5q35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXW11   13607
Cards
Entrez_Gene (NCBI)FBXW11  23291  F-box and WD repeat domain containing 11
AliasesBTRC2; BTRCP2; FBW1B; FBXW1B; 
Fbw11; Hos
GeneCards (Weizmann)FBXW11
Ensembl hg19 (Hinxton)ENSG00000072803 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072803 [Gene_View]  chr5:171861552-172006873 [Contig_View]  FBXW11 [Vega]
ICGC DataPortalENSG00000072803
TCGA cBioPortalFBXW11
AceView (NCBI)FBXW11
Genatlas (Paris)FBXW11
WikiGenes23291
SOURCE (Princeton)FBXW11
Genetics Home Reference (NIH)FBXW11
Genomic and cartography
GoldenPath hg38 (UCSC)FBXW11  -     chr5:171861552-172006873 -  5q35.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXW11  -     5q35.1   [Description]    (hg19-Feb_2009)
EnsemblFBXW11 - 5q35.1 [CytoView hg19]  FBXW11 - 5q35.1 [CytoView hg38]
Mapping of homologs : NCBIFBXW11 [Mapview hg19]  FBXW11 [Mapview hg38]
OMIM605651   
Gene and transcription
Genbank (Entrez)AB014596 AB033279 AB033280 AB033281 AF176022
RefSeq transcript (Entrez)NM_012300 NM_033644 NM_033645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXW11
Cluster EST : UnigeneHs.484138 [ NCBI ]
CGAP (NCI)Hs.484138
Alternative Splicing GalleryENSG00000072803
Gene ExpressionFBXW11 [ NCBI-GEO ]   FBXW11 [ EBI - ARRAY_EXPRESS ]   FBXW11 [ SEEK ]   FBXW11 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23291
GTEX Portal (Tissue expression)FBXW11
Human Protein AtlasENSG00000072803-FBXW11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKB1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKB1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKB1
Splice isoforms : SwissVarQ9UKB1
PhosPhoSitePlusQ9UKB1
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Beta-TrCP_D    F-box_dom    G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)Beta-TrCP_D (PF12125)    F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12125    pfam12937    pfam00400   
Domain families : Smart (EMBL)Beta-TrCP_D (SM01028)  FBOX (SM00256)  WD40 (SM00320)  
Conserved Domain (NCBI)FBXW11
DMDM Disease mutations23291
Blocks (Seattle)FBXW11
SuperfamilyQ9UKB1
Human Protein Atlas [tissue]ENSG00000072803-FBXW11 [tissue]
Peptide AtlasQ9UKB1
HPRD07294
IPIIPI00328796   IPI00306671   IPI00301283   IPI01013614   IPI00973806   IPI00973949   IPI00973919   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKB1
IntAct (EBI)Q9UKB1
FunCoupENSG00000072803
BioGRIDFBXW11
STRING (EMBL)FBXW11
ZODIACFBXW11
Ontologies - Pathways
QuickGOQ9UKB1
Ontology : AmiGOG2/M transition of mitotic cell cycle  ubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  centrosome  cytosol  cytosol  protein dephosphorylation  Wnt signaling pathway  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  protein destabilization  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of NF-kappaB import into nucleus  positive regulation of circadian rhythm  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  protein dimerization activity  rhythmic process  T cell receptor signaling pathway  stress-activated MAPK cascade  ubiquitin protein ligase activity  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  ubiquitin ligase complex  protein polyubiquitination  protein polyubiquitination  stimulatory C-type lectin receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  centrosome  cytosol  cytosol  protein dephosphorylation  Wnt signaling pathway  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  protein destabilization  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  negative regulation of NF-kappaB import into nucleus  positive regulation of circadian rhythm  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of proteolysis  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  protein dimerization activity  rhythmic process  T cell receptor signaling pathway  stress-activated MAPK cascade  ubiquitin protein ligase activity  
Pathways : KEGGOocyte meiosis    Ubiquitin mediated proteolysis    Wnt signaling pathway    Hedgehog signaling pathway    Hippo signaling pathway    Circadian rhythm    Shigellosis   
NDEx NetworkFBXW11
Atlas of Cancer Signalling NetworkFBXW11
Wikipedia pathwaysFBXW11
Orthology - Evolution
OrthoDB23291
GeneTree (enSembl)ENSG00000072803
Phylogenetic Trees/Animal Genes : TreeFamFBXW11
HOVERGENQ9UKB1
HOGENOMQ9UKB1
Homologs : HomoloGeneFBXW11
Homology/Alignments : Family Browser (UCSC)FBXW11
Gene fusions - Rearrangements
Tumor Fusion PortalFBXW11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW11
dbVarFBXW11
ClinVarFBXW11
1000_GenomesFBXW11 
Exome Variant ServerFBXW11
ExAC (Exome Aggregation Consortium)ENSG00000072803
GNOMAD BrowserENSG00000072803
Genetic variants : HAPMAP23291
Genomic Variants (DGV)FBXW11 [DGVbeta]
DECIPHERFBXW11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXW11 
Mutations
ICGC Data PortalFBXW11 
TCGA Data PortalFBXW11 
Broad Tumor PortalFBXW11
OASIS PortalFBXW11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXW11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW11
DgiDB (Drug Gene Interaction Database)FBXW11
DoCM (Curated mutations)FBXW11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW11 (select a term)
intoGenFBXW11
Cancer3DFBXW11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605651   
Orphanet
DisGeNETFBXW11
MedgenFBXW11
Genetic Testing Registry FBXW11
NextProtQ9UKB1 [Medical]
TSGene23291
GENETestsFBXW11
Target ValidationFBXW11
Huge Navigator FBXW11 [HugePedia]
snp3D : Map Gene to Disease23291
BioCentury BCIQFBXW11
ClinGenFBXW11 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23291
Chemical/Pharm GKB GenePA28050
Clinical trialFBXW11
Miscellaneous
canSAR (ICR)FBXW11 (select the gene name)
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW11
EVEXFBXW11
GoPubMedFBXW11
iHOPFBXW11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:13:04 CET 2017

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