Atlas of Genetics and Cytogenetics in Oncology and Haematology

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FBXW12 (F-box and WD repeat domain containing 12)

Identity

Alias_namesFBXO35
F-box only protein 35
F-box and WD-40 domain protein 12
Alias_symbol (synonym)Fbw12
Other aliasFBW12
FBXO12
HGNC (Hugo) FBXW12
LocusID (NCBI) 285231
Atlas_Id 56623
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48372219 and ends at 48394725 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FBXW12   20729
Cards
Entrez_Gene (NCBI)FBXW12  285231  F-box and WD repeat domain containing 12
AliasesFBW12; FBXO12; FBXO35
GeneCards (Weizmann)FBXW12
Ensembl hg19 (Hinxton)ENSG00000164049 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164049 [Gene_View]  chr3:48372219-48394725 [Contig_View]  FBXW12 [Vega]
ICGC DataPortalENSG00000164049
TCGA cBioPortalFBXW12
AceView (NCBI)FBXW12
Genatlas (Paris)FBXW12
WikiGenes285231
SOURCE (Princeton)FBXW12
Genetics Home Reference (NIH)FBXW12
Genomic and cartography
GoldenPath hg38 (UCSC)FBXW12  -     chr3:48372219-48394725 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXW12  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblFBXW12 - 3p21.31 [CytoView hg19]  FBXW12 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIFBXW12 [Mapview hg19]  FBXW12 [Mapview hg38]
OMIM609075   
Gene and transcription
Genbank (Entrez)AK097594 AY247969 BC101303 BC101304 BC101305
RefSeq transcript (Entrez)NM_001159927 NM_001159929 NM_207102
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXW12
Cluster EST : UnigeneHs.288793 [ NCBI ]
CGAP (NCI)Hs.288793
Alternative Splicing GalleryENSG00000164049
Gene ExpressionFBXW12 [ NCBI-GEO ]   FBXW12 [ EBI - ARRAY_EXPRESS ]   FBXW12 [ SEEK ]   FBXW12 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)285231
GTEX Portal (Tissue expression)FBXW12
Human Protein AtlasENSG00000164049-FBXW12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6X9E4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6X9E4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6X9E4
Splice isoforms : SwissVarQ6X9E4
PhosPhoSitePlusQ6X9E4
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)   
Domains : Interpro (EBI)F-box_dom    Quino_amine_DH_bsu    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  
Conserved Domain (NCBI)FBXW12
DMDM Disease mutations285231
Blocks (Seattle)FBXW12
SuperfamilyQ6X9E4
Human Protein Atlas [tissue]ENSG00000164049-FBXW12 [tissue]
Peptide AtlasQ6X9E4
HPRD16428
IPIIPI00410182   IPI00925395   IPI00924811   IPI00749355   
Protein Interaction databases
DIP (DOE-UCLA)Q6X9E4
IntAct (EBI)Q6X9E4
FunCoupENSG00000164049
BioGRIDFBXW12
STRING (EMBL)FBXW12
ZODIACFBXW12
Ontologies - Pathways
QuickGOQ6X9E4
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytosol  post-translational protein modification  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  cytosol  post-translational protein modification  
NDEx NetworkFBXW12
Atlas of Cancer Signalling NetworkFBXW12
Wikipedia pathwaysFBXW12
Orthology - Evolution
OrthoDB285231
GeneTree (enSembl)ENSG00000164049
Phylogenetic Trees/Animal Genes : TreeFamFBXW12
HOVERGENQ6X9E4
HOGENOMQ6X9E4
Homologs : HomoloGeneFBXW12
Homology/Alignments : Family Browser (UCSC)FBXW12
Gene fusions - Rearrangements
Fusion : QuiverFBXW12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW12
dbVarFBXW12
ClinVarFBXW12
1000_GenomesFBXW12 
Exome Variant ServerFBXW12
ExAC (Exome Aggregation Consortium)ENSG00000164049
GNOMAD BrowserENSG00000164049
Genetic variants : HAPMAP285231
Genomic Variants (DGV)FBXW12 [DGVbeta]
DECIPHERFBXW12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXW12 
Mutations
ICGC Data PortalFBXW12 
TCGA Data PortalFBXW12 
Broad Tumor PortalFBXW12
OASIS PortalFBXW12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXW12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW12
DgiDB (Drug Gene Interaction Database)FBXW12
DoCM (Curated mutations)FBXW12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW12 (select a term)
intoGenFBXW12
Cancer3DFBXW12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609075   
Orphanet
DisGeNETFBXW12
MedgenFBXW12
Genetic Testing Registry FBXW12
NextProtQ6X9E4 [Medical]
TSGene285231
GENETestsFBXW12
Target ValidationFBXW12
Huge Navigator FBXW12 [HugePedia]
snp3D : Map Gene to Disease285231
BioCentury BCIQFBXW12
ClinGenFBXW12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD285231
Chemical/Pharm GKB GenePA134980842
Clinical trialFBXW12
Miscellaneous
canSAR (ICR)FBXW12 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW12
EVEXFBXW12
GoPubMedFBXW12
iHOPFBXW12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:12:28 CET 2018
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