Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXW4 (F-box and WD repeat domain containing 4)

Identity

Alias_namesSHFM3
split hand/foot malformation (ectrodactyly) type 3
F-box and WD-40 domain protein 4
Alias_symbol (synonym)Fbw4
dactylin
Other aliasDAC
FBW4
FBWD4
SHSF3
HGNC (Hugo) FBXW4
LocusID (NCBI) 6468
Atlas_Id 56538
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 101610664 and ends at 101695295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
B4GALT5 (20q13.13) / FBXW4 (10q24.32)FBXW4 (10q24.32) / ANKRD44 (2q33.1)FBXW4 (10q24.32) / SLC16A1 (1p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXW4   10847
Cards
Entrez_Gene (NCBI)FBXW4  6468  F-box and WD repeat domain containing 4
AliasesDAC; FBW4; FBWD4; SHFM3; 
SHSF3
GeneCards (Weizmann)FBXW4
Ensembl hg19 (Hinxton)ENSG00000107829 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107829 [Gene_View]  chr10:101610664-101695295 [Contig_View]  FBXW4 [Vega]
ICGC DataPortalENSG00000107829
TCGA cBioPortalFBXW4
AceView (NCBI)FBXW4
Genatlas (Paris)FBXW4
WikiGenes6468
SOURCE (Princeton)FBXW4
Genetics Home Reference (NIH)FBXW4
Genomic and cartography
GoldenPath hg38 (UCSC)FBXW4  -     chr10:101610664-101695295 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXW4  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblFBXW4 - 10q24.32 [CytoView hg19]  FBXW4 - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBIFBXW4 [Mapview hg19]  FBXW4 [Mapview hg38]
OMIM608071   
Gene and transcription
Genbank (Entrez)AF281859 AK056917 AK123173 AK314735 BC007380
RefSeq transcript (Entrez)NM_001323541 NM_022039
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FBXW4
Cluster EST : UnigeneHs.500822 [ NCBI ]
CGAP (NCI)Hs.500822
Alternative Splicing GalleryENSG00000107829
Gene ExpressionFBXW4 [ NCBI-GEO ]   FBXW4 [ EBI - ARRAY_EXPRESS ]   FBXW4 [ SEEK ]   FBXW4 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6468
GTEX Portal (Tissue expression)FBXW4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57775
Splice isoforms : SwissVarP57775
PhosPhoSitePlusP57775
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box_dom    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12937    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)FBXW4
DMDM Disease mutations6468
Blocks (Seattle)FBXW4
SuperfamilyP57775
Human Protein AtlasENSG00000107829
Peptide AtlasP57775
HPRD06994
IPIIPI00796331   IPI00641322   IPI00873261   
Protein Interaction databases
DIP (DOE-UCLA)P57775
IntAct (EBI)P57775
FunCoupENSG00000107829
BioGRIDFBXW4
STRING (EMBL)FBXW4
ZODIACFBXW4
Ontologies - Pathways
QuickGOP57775
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  positive regulation of mesenchymal cell proliferation  molecular_function  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  ubiquitin-dependent protein catabolic process  Wnt signaling pathway  SCF ubiquitin ligase complex  embryonic limb morphogenesis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  embryonic digit morphogenesis  cartilage development  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  positive regulation of mesenchymal cell proliferation  molecular_function  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  cytosol  ubiquitin-dependent protein catabolic process  Wnt signaling pathway  SCF ubiquitin ligase complex  embryonic limb morphogenesis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  embryonic digit morphogenesis  cartilage development  
NDEx NetworkFBXW4
Atlas of Cancer Signalling NetworkFBXW4
Wikipedia pathwaysFBXW4
Orthology - Evolution
OrthoDB6468
GeneTree (enSembl)ENSG00000107829
Phylogenetic Trees/Animal Genes : TreeFamFBXW4
HOVERGENP57775
HOGENOMP57775
Homologs : HomoloGeneFBXW4
Homology/Alignments : Family Browser (UCSC)FBXW4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW4
dbVarFBXW4
ClinVarFBXW4
1000_GenomesFBXW4 
Exome Variant ServerFBXW4
ExAC (Exome Aggregation Consortium)FBXW4 (select the gene name)
Genetic variants : HAPMAP6468
Genomic Variants (DGV)FBXW4 [DGVbeta]
DECIPHERFBXW4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXW4 
Mutations
ICGC Data PortalFBXW4 
TCGA Data PortalFBXW4 
Broad Tumor PortalFBXW4
OASIS PortalFBXW4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXW4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW4
DgiDB (Drug Gene Interaction Database)FBXW4
DoCM (Curated mutations)FBXW4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW4 (select a term)
intoGenFBXW4
Cancer3DFBXW4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608071   
Orphanet
MedgenFBXW4
Genetic Testing Registry FBXW4
NextProtP57775 [Medical]
TSGene6468
GENETestsFBXW4
Target ValidationFBXW4
Huge Navigator FBXW4 [HugePedia]
snp3D : Map Gene to Disease6468
BioCentury BCIQFBXW4
ClinGenFBXW4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6468
Chemical/Pharm GKB GenePA35751
Clinical trialFBXW4
Miscellaneous
canSAR (ICR)FBXW4 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW4
EVEXFBXW4
GoPubMedFBXW4
iHOPFBXW4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:33:40 CEST 2017

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