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FBXW4 (F-box and WD repeat domain containing 4)

Identity

Alias (NCBI)DAC
FBW4
FBWD4
SHFM3
SHSF3
HGNC (Hugo) FBXW4
HGNC Alias symbFbw4
dactylin
HGNC Previous nameSHFM3
HGNC Previous namesplit hand/foot malformation (ectrodactyly) type 3
 F-box and WD-40 domain protein 4
LocusID (NCBI) 6468
Atlas_Id 56538
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 101610666 and ends at 101695170 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
B4GALT5 (20q13.13) / FBXW4 (10q24.32)FBXW4 (10q24.32) / ANKRD44 (2q33.1)FBXW4 (10q24.32) / SLC16A1 (1p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FBXW4   10847
Cards
Entrez_Gene (NCBI)FBXW4    F-box and WD repeat domain containing 4
AliasesDAC; FBW4; FBWD4; SHFM3; 
SHSF3
GeneCards (Weizmann)FBXW4
Ensembl hg19 (Hinxton)ENSG00000107829 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107829 [Gene_View]  ENSG00000107829 [Sequence]  chr10:101610666-101695170 [Contig_View]  FBXW4 [Vega]
ICGC DataPortalENSG00000107829
TCGA cBioPortalFBXW4
AceView (NCBI)FBXW4
Genatlas (Paris)FBXW4
SOURCE (Princeton)FBXW4
Genetics Home Reference (NIH)FBXW4
Genomic and cartography
GoldenPath hg38 (UCSC)FBXW4  -     chr10:101610666-101695170 -  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FBXW4  -     10q24.32   [Description]    (hg19-Feb_2009)
GoldenPathFBXW4 - 10q24.32 [CytoView hg19]  FBXW4 - 10q24.32 [CytoView hg38]
ImmunoBaseENSG00000107829
Genome Data Viewer NCBIFBXW4 [Mapview hg19]  
OMIM608071   
Gene and transcription
Genbank (Entrez)AF281859 AK056917 AK123173 AK314735 BC007380
RefSeq transcript (Entrez)NM_001323541 NM_022039
Consensus coding sequences : CCDS (NCBI)FBXW4
Gene ExpressionFBXW4 [ NCBI-GEO ]   FBXW4 [ EBI - ARRAY_EXPRESS ]   FBXW4 [ SEEK ]   FBXW4 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW4 [ Firebrowse - Broad ]
GenevisibleExpression of FBXW4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6468
GTEX Portal (Tissue expression)FBXW4
Human Protein AtlasENSG00000107829-FBXW4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57775
PhosPhoSitePlusP57775
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box-like_dom_sf    F-box_dom    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12937    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)FBXW4
SuperfamilyP57775
AlphaFold pdb e-kbP57775   
Human Protein Atlas [tissue]ENSG00000107829-FBXW4 [tissue]
HPRD06994
Protein Interaction databases
DIP (DOE-UCLA)P57775
IntAct (EBI)P57775
BioGRIDFBXW4
STRING (EMBL)FBXW4
ZODIACFBXW4
Ontologies - Pathways
QuickGOP57775
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  protein binding  cytosol  ubiquitin-dependent protein catabolic process  Wnt signaling pathway  SCF ubiquitin ligase complex  embryonic limb morphogenesis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  post-translational protein modification  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  protein binding  cytosol  ubiquitin-dependent protein catabolic process  Wnt signaling pathway  SCF ubiquitin ligase complex  embryonic limb morphogenesis  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  post-translational protein modification  
NDEx NetworkFBXW4
Atlas of Cancer Signalling NetworkFBXW4
Wikipedia pathwaysFBXW4
Orthology - Evolution
OrthoDB6468
GeneTree (enSembl)ENSG00000107829
Phylogenetic Trees/Animal Genes : TreeFamFBXW4
Homologs : HomoloGeneFBXW4
Homology/Alignments : Family Browser (UCSC)FBXW4
Gene fusions - Rearrangements
Fusion : QuiverFBXW4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW4
dbVarFBXW4
ClinVarFBXW4
MonarchFBXW4
1000_GenomesFBXW4 
Exome Variant ServerFBXW4
GNOMAD BrowserENSG00000107829
Varsome BrowserFBXW4
ACMGFBXW4 variants
VarityP57775
Genomic Variants (DGV)FBXW4 [DGVbeta]
DECIPHERFBXW4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFBXW4 
Mutations
ICGC Data PortalFBXW4 
TCGA Data PortalFBXW4 
Broad Tumor PortalFBXW4
OASIS PortalFBXW4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFBXW4
Mutations and Diseases : HGMDFBXW4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFBXW4
DgiDB (Drug Gene Interaction Database)FBXW4
DoCM (Curated mutations)FBXW4
CIViC (Clinical Interpretations of Variants in Cancer)FBXW4
Cancer3DFBXW4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608071   
Orphanet
DisGeNETFBXW4
MedgenFBXW4
Genetic Testing Registry FBXW4
NextProtP57775 [Medical]
GENETestsFBXW4
Target ValidationFBXW4
Huge Navigator FBXW4 [HugePedia]
ClinGenFBXW4
Clinical trials, drugs, therapy
MyCancerGenomeFBXW4
Protein Interactions : CTDFBXW4
Pharm GKB GenePA35751
PharosP57775
Clinical trialFBXW4
Miscellaneous
canSAR (ICR)FBXW4
HarmonizomeFBXW4
DataMed IndexFBXW4
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFBXW4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:12 CEST 2021

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