Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXW7 (F-box and WD repeat domain containing 7)

Identity

Other namesAGO
CDC4
FBW6
FBW7
FBX30
FBXO30
FBXW6
SEL-10
SEL10
hAgo
hCdc4
HGNC (Hugo) FBXW7
LocusID (NCBI) 55294
Atlas_Id 40542
Location 4q31.3
Location_base_pair Starts at 153242410 and ends at 153303664 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FBXW7 (4q31.3) / ARHGAP10 (4q31.23)FBXW7 (4q31.3) / INPP4B (4q31.21)FBXW7 (4q31.3) / KLF12 (13q22.1)
FBXW7 (4q31.3) / PRR4 (12p13.2)FBXW7 (4q31.3) / TMEM126B (11q14.1)FBXW7 (4q31.3) / TMEM154 (4q31.3)
RUNX1 (21q22.12) / FBXW7 (4q31.3)SLC20A2 (8p11.21) / FBXW7 (4q31.3)FBXW7 4q31.3 / ARHGAP10 4q31.23
FBXW7 4q31.3 / INPP4B 4q31.21FBXW7 4q31.3 / TMEM126B 11q14.1FBXW7 4q31.3 / TMEM154 4q31.3
SLC20A2 8p11.21 / FBXW7 4q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Colon: Colorectal adenocarcinoma

External links

Nomenclature
HGNC (Hugo)FBXW7   16712
Cards
Entrez_Gene (NCBI)FBXW7  55294  F-box and WD repeat domain containing 7
GeneCards (Weizmann)FBXW7
Ensembl hg19 (Hinxton)ENSG00000109670 [Gene_View]  chr4:153242410-153303664 [Contig_View]  FBXW7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109670 [Gene_View]  chr4:153242410-153303664 [Contig_View]  FBXW7 [Vega]
ICGC DataPortalENSG00000109670
TCGA cBioPortalFBXW7
AceView (NCBI)FBXW7
Genatlas (Paris)FBXW7
WikiGenes55294
SOURCE (Princeton)FBXW7
Genomic and cartography
GoldenPath hg19 (UCSC)FBXW7  -     chr4:153242410-153303664 -  4q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FBXW7  -     4q31.3   [Description]    (hg38-Dec_2013)
EnsemblFBXW7 - 4q31.3 [CytoView hg19]  FBXW7 - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIFBXW7 [Mapview hg19]  FBXW7 [Mapview hg38]
OMIM606278   
Gene and transcription
Genbank (Entrez)AB209725 AF383178 AF411971 AF411972 AI598129
RefSeq transcript (Entrez)NM_001013415 NM_001257069 NM_018315 NM_033632
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_029466 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)FBXW7
Cluster EST : UnigeneHs.717081 [ NCBI ]
CGAP (NCI)Hs.717081
Alternative Splicing : Fast-db (Paris)GSHG0023591
Alternative Splicing GalleryENSG00000109670
Gene ExpressionFBXW7 [ NCBI-GEO ]   FBXW7 [ EBI - ARRAY_EXPRESS ]   FBXW7 [ SEEK ]   FBXW7 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)55294
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969H0 (Uniprot)
NextProtQ969H0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969H0
Splice isoforms : SwissVarQ969H0 (Swissvar)
PhosPhoSitePlusQ969H0
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box_dom    G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12937    pfam00400   
Domain families : Smart (EMBL)FBOX (SM00256)  WD40 (SM00320)  
DMDM Disease mutations55294
Blocks (Seattle)FBXW7
PDB (SRS)2OVP    2OVQ    2OVR   
PDB (PDBSum)2OVP    2OVQ    2OVR   
PDB (IMB)2OVP    2OVQ    2OVR   
PDB (RSDB)2OVP    2OVQ    2OVR   
Structural Biology KnowledgeBase2OVP    2OVQ    2OVR   
SCOP (Structural Classification of Proteins)2OVP    2OVQ    2OVR   
CATH (Classification of proteins structures)2OVP    2OVQ    2OVR   
SuperfamilyQ969H0
Human Protein AtlasENSG00000109670
Peptide AtlasQ969H0
HPRD05888
IPIIPI00056349   IPI00059165   IPI00402151   IPI00075075   IPI01010101   
Protein Interaction databases
DIP (DOE-UCLA)Q969H0
IntAct (EBI)Q969H0
FunCoupENSG00000109670
BioGRIDFBXW7
STRING (EMBL)FBXW7
ZODIACFBXW7
Ontologies - Pathways
QuickGOQ969H0
Ontology : AmiGOprotein polyubiquitination  vasculature development  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytosol  cellular response to DNA damage stimulus  sister chromatid cohesion  negative regulation of triglyceride biosynthetic process  regulation of lipid storage  viral process  protein ubiquitination  SCF ubiquitin ligase complex  cyclin binding  cyclin binding  protein binding, bridging  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of DNA endoreduplication  regulation of protein localization  cellular response to UV  identical protein binding  protein complex  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  phosphothreonine binding  protein stabilization  positive regulation of ubiquitin-protein transferase activity  lipid homeostasis  positive regulation of ERK1 and ERK2 cascade  ubiquitin-protein transferase activator activity  positive regulation of proteasomal protein catabolic process  regulation of cell cycle G1/S phase transition  regulation of mitophagy  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of protein targeting to mitochondrion  Parkin-FBXW7-Cul1 ubiquitin ligase complex  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of hepatocyte proliferation  negative regulation of SREBP signaling pathway  
Ontology : EGO-EBIprotein polyubiquitination  vasculature development  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytosol  cellular response to DNA damage stimulus  sister chromatid cohesion  negative regulation of triglyceride biosynthetic process  regulation of lipid storage  viral process  protein ubiquitination  SCF ubiquitin ligase complex  cyclin binding  cyclin binding  protein binding, bridging  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of DNA endoreduplication  regulation of protein localization  cellular response to UV  identical protein binding  protein complex  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  phosphothreonine binding  protein stabilization  positive regulation of ubiquitin-protein transferase activity  lipid homeostasis  positive regulation of ERK1 and ERK2 cascade  ubiquitin-protein transferase activator activity  positive regulation of proteasomal protein catabolic process  regulation of cell cycle G1/S phase transition  regulation of mitophagy  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of protein targeting to mitochondrion  Parkin-FBXW7-Cul1 ubiquitin ligase complex  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of hepatocyte proliferation  negative regulation of SREBP signaling pathway  
Pathways : BIOCARTACyclin E Destruction Pathway [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx Network
Atlas of Cancer Signalling NetworkFBXW7
Wikipedia pathwaysFBXW7
Orthology - Evolution
OrthoDB55294
GeneTree (enSembl)ENSG00000109670
Phylogenetic Trees/Animal Genes : TreeFamFBXW7
Homologs : HomoloGeneFBXW7
Homology/Alignments : Family Browser (UCSC)FBXW7
Gene fusions - Rearrangements
Fusion: TCGAFBXW7 4q31.3 ARHGAP10 4q31.23 BLCA
Fusion: TCGAFBXW7 4q31.3 INPP4B 4q31.21 LUSC
Fusion: TCGAFBXW7 4q31.3 TMEM126B 11q14.1 LGG
Fusion: TCGAFBXW7 4q31.3 TMEM154 4q31.3 BRCA
Fusion: TCGASLC20A2 8p11.21 FBXW7 4q31.3 LUSC
Polymorphisms : SNP, variants
NCBI Variation ViewerFBXW7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW7
dbVarFBXW7
ClinVarFBXW7
1000_GenomesFBXW7 
Exome Variant ServerFBXW7
ExAC (Exome Aggregation Consortium)FBXW7 (select the gene name)
SNP (GeneSNP Utah)FBXW7
SNP : HGBaseFBXW7
Genetic variants : HAPMAPFBXW7
Genomic Variants (DGV)FBXW7 [DGVbeta]
Mutations
ICGC Data PortalFBXW7 
TCGA Data PortalFBXW7 
Broad Tumor PortalFBXW7
OASIS PortalFBXW7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW7
DgiDB (Drug Gene Interaction Database)FBXW7
DoCM (Curated mutations)FBXW7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW7 (select a term)
intoGenFBXW7
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:153242410-153303664
CONAN: Copy Number AnalysisFBXW7 
Mutations and Diseases : HGMDFBXW7
OMIM606278   
MedgenFBXW7
Genetic Testing Registry FBXW7
NextProtQ969H0 [Medical]
TSGene55294
GENETestsFBXW7
Huge Navigator FBXW7 [HugePedia]  FBXW7 [HugeCancerGEM]
snp3D : Map Gene to Disease55294
BioCentury BCIQFBXW7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55294
Chemical/Pharm GKB GenePA28054
Drug Sensitivity FBXW7
Clinical trialFBXW7
Miscellaneous
canSAR (ICR)FBXW7 (select the gene name)
Probes
Litterature
PubMed252 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW7
GoPubMedFBXW7
iHOPFBXW7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 17:44:43 CEST 2016

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