Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXW7 (F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase)

Identity

Other namesAGO
CDC4
FBW6
FBW7
FBX30
FBXO30
FBXW6
SEL-10
SEL10
hAgo
hCdc4
HGNC (Hugo) FBXW7
LocusID (NCBI) 55294
Atlas_Id 40542
Location 4q31.3
Location_base_pair Starts at 153242410 and ends at 153303664 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)FBXW7   16712
Cards
Entrez_Gene (NCBI)FBXW7  55294  F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
GeneCards (Weizmann)FBXW7
Ensembl hg19 (Hinxton)ENSG00000109670 [Gene_View]  chr4:153242410-153303664 [Contig_View]  FBXW7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000109670 [Gene_View]  chr4:153242410-153303664 [Contig_View]  FBXW7 [Vega]
ICGC DataPortalENSG00000109670
TCGA cBioPortalFBXW7
AceView (NCBI)FBXW7
Genatlas (Paris)FBXW7
WikiGenes55294
SOURCE (Princeton)FBXW7
Genomic and cartography
GoldenPath hg19 (UCSC)FBXW7  -     chr4:153242410-153303664 -  4q31.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FBXW7  -     4q31.3   [Description]    (hg38-Dec_2013)
EnsemblFBXW7 - 4q31.3 [CytoView hg19]  FBXW7 - 4q31.3 [CytoView hg38]
Mapping of homologs : NCBIFBXW7 [Mapview hg19]  FBXW7 [Mapview hg38]
OMIM606278   
Gene and transcription
Genbank (Entrez)AB209725 AF383178 AF411971 AF411972 AI598129
RefSeq transcript (Entrez)NM_001013415 NM_001257069 NM_018315 NM_033632
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_029466 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)FBXW7
Cluster EST : UnigeneHs.717081 [ NCBI ]
CGAP (NCI)Hs.717081
Alternative Splicing : Fast-db (Paris)GSHG0023591
Alternative Splicing GalleryENSG00000109670
Gene ExpressionFBXW7 [ NCBI-GEO ]     FBXW7 [ SEEK ]   FBXW7 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969H0 (Uniprot)
NextProtQ969H0  [Medical]  [Publications]
With graphics : InterProQ969H0
Splice isoforms : SwissVarQ969H0 (Swissvar)
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box_dom    G-protein_beta_WD-40_rep    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Related proteins : CluSTrQ969H0
Domain families : Pfam (Sanger)F-box-like (PF12937)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam12937    pfam00400   
Domain families : Smart (EMBL)FBOX (SM00256)  WD40 (SM00320)  
DMDM Disease mutations55294
Blocks (Seattle)Q969H0
PDB (SRS)2OVP    2OVQ    2OVR   
PDB (PDBSum)2OVP    2OVQ    2OVR   
PDB (IMB)2OVP    2OVQ    2OVR   
PDB (RSDB)2OVP    2OVQ    2OVR   
Human Protein AtlasENSG00000109670
Peptide AtlasQ969H0
HPRD05888
IPIIPI00056349   IPI00059165   IPI00402151   IPI00075075   IPI01010101   
Protein Interaction databases
DIP (DOE-UCLA)Q969H0
IntAct (EBI)Q969H0
FunCoupENSG00000109670
BioGRIDFBXW7
IntegromeDBFBXW7
STRING (EMBL)FBXW7
Ontologies - Pathways
QuickGOQ969H0
Ontology : AmiGOvasculogenesis  vasculature development  sequence-specific DNA binding transcription factor activity  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  endoplasmic reticulum  Golgi apparatus  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  sister chromatid cohesion  Notch signaling pathway  negative regulation of triglyceride biosynthetic process  regulation of lipid storage  viral process  protein ubiquitination  SCF ubiquitin ligase complex  lung development  cyclin binding  protein binding, bridging  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of DNA endoreduplication  regulation of protein localization  cellular response to UV  identical protein binding  protein complex  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  protein stabilization  positive regulation of ubiquitin-protein transferase activity  lipid homeostasis  positive regulation of ERK1 and ERK2 cascade  ubiquitin-protein transferase activator activity  positive regulation of proteasomal protein catabolic process  regulation of cell cycle G1/S phase transition  regulation of mitochondrion degradation  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of protein targeting to mitochondrion  Parkin-FBXW7-Cul1 ubiquitin ligase complex  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of hepatocyte proliferation  negative regulation of SREBP signaling pathway  
Ontology : EGO-EBIvasculogenesis  vasculature development  sequence-specific DNA binding transcription factor activity  protein binding  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytoplasm  endoplasmic reticulum  Golgi apparatus  regulation of transcription, DNA-templated  cellular response to DNA damage stimulus  sister chromatid cohesion  Notch signaling pathway  negative regulation of triglyceride biosynthetic process  regulation of lipid storage  viral process  protein ubiquitination  SCF ubiquitin ligase complex  lung development  cyclin binding  protein binding, bridging  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  negative regulation of DNA endoreduplication  regulation of protein localization  cellular response to UV  identical protein binding  protein complex  positive regulation of epidermal growth factor-activated receptor activity  negative regulation of Notch signaling pathway  protein stabilization  positive regulation of ubiquitin-protein transferase activity  lipid homeostasis  positive regulation of ERK1 and ERK2 cascade  ubiquitin-protein transferase activator activity  positive regulation of proteasomal protein catabolic process  regulation of cell cycle G1/S phase transition  regulation of mitochondrion degradation  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of protein targeting to mitochondrion  Parkin-FBXW7-Cul1 ubiquitin ligase complex  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  negative regulation of hepatocyte proliferation  negative regulation of SREBP signaling pathway  
Pathways : BIOCARTACyclin E Destruction Pathway [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis   
Protein Interaction DatabaseFBXW7
DoCM (Curated mutations)FBXW7
Wikipedia pathwaysFBXW7
Gene fusion - Rearrangements
Gene fusion: TCGAFBXW7 ARHGAP10  FBXW7 TMEM154  FBXW7 TMEM126B  FBXW7 INPP4B  
Polymorphisms : SNP, variants
NCBI Variation ViewerFBXW7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW7
dbVarFBXW7
ClinVarFBXW7
1000_GenomesFBXW7 
Exome Variant ServerFBXW7
SNP (GeneSNP Utah)FBXW7
SNP : HGBaseFBXW7
Genetic variants : HAPMAPFBXW7
Genomic Variants (DGV)FBXW7 [DGVbeta]
Mutations
ICGC Data PortalFBXW7 
TCGA Data PortalFBXW7 
Tumor PortalFBXW7
Cancer Gene: CensusFBXW7 
Somatic Mutations in Cancer : COSMICFBXW7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:153242410-153303664
CONAN: Copy Number AnalysisFBXW7 
Mutations and Diseases : HGMDFBXW7
OMIM606278   
MedgenFBXW7
NextProtQ969H0 [Medical]
GENETestsFBXW7
Disease Genetic AssociationFBXW7
Huge Navigator FBXW7 [HugePedia]  FBXW7 [HugeCancerGEM]
snp3D : Map Gene to Disease55294
DGIdb (Drug Gene Interaction db)FBXW7
BioCentury BCIQFBXW7
General knowledge
Homologs : HomoloGeneFBXW7
Homology/Alignments : Family Browser (UCSC)FBXW7
Phylogenetic Trees/Animal Genes : TreeFamFBXW7
Chemical/Protein Interactions : CTD55294
Chemical/Pharm GKB GenePA28054
Drug Sensitivity FBXW7
Clinical trialFBXW7
Cancer Resource (Charite)ENSG00000109670
Other databases
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
CoreMineFBXW7
GoPubMedFBXW7
iHOPFBXW7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 11:33:25 CEST 2015

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