FBXW8 (F-box and WD repeat domain containing 8)

2010-04-01  

Identity

HGNC
LOCATION
12q24.22
LOCUSID
ALIAS
FBW6,FBW8,FBX29,FBXO29,FBXW6
FUSION GENES

Other Information

Locus ID:

NCBI: 26259
MIM: 609073
HGNC: 13597
Ensembl: ENSG00000174989

Variants:

dbSNP: 26259
ClinVar: 26259
TCGA: ENSG00000174989
COSMIC: FBXW8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174989ENST00000309909A0A499FIY5
ENSG00000174989ENST00000455858Q8N3Y1
ENSG00000174989ENST00000652555Q8N3Y1

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172051322006A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation.93
179983352008Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.21
243620262014The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.15
230295302012Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is mediated by CUL7 E3 ligase.8
249737092014MicroRNA-218 inhibits the proliferation of human choriocarcinoma JEG-3 cell line by targeting Fbxw8.8
208784772011Fbxw8 is involved in the proliferation of human choriocarcinoma JEG-3 cells.7
257904752015Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.6
225246832012Cullin 7 and Fbxw 8 expression in trophoblastic cells is regulated via oxygen tension: implications for intrauterine growth restriction?0
293108372018Assessment of a FBXW8 frameshift mutation, c.1312_1313delGT, in breast cancer patients and controls from Central Europe.0

Citation

Dessen P

FBXW8 (F-box and WD repeat domain containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51418/fbxw8