Atlas of Genetics and Cytogenetics in Oncology and Haematology


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FBXW8 (F-box and WD repeat domain containing 8)

Identity

Alias_namesFBXO29
F-box only protein 29
F-box and WD-40 domain protein 8
Alias_symbol (synonym)FBX29
FBW6
FBW8
Other aliasFBXW6
HGNC (Hugo) FBXW8
LocusID (NCBI) 26259
Atlas_Id 51418
Location 12q24.22  [Link to chromosome band 12q24]
Location_base_pair Starts at 117348761 and ends at 117468953 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FBXW8 (12q24.22) / CHST11 (12q23.3)FBXW8 (12q24.22) / FBXW8 (12q24.22)ULK1 (12q24.33) / FBXW8 (12q24.22)
FBXW8 12q24.22 / CHST11 12q23.3ULK1 12q24.33 / FBXW8 12q24.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FBXW8   13597
Cards
Entrez_Gene (NCBI)FBXW8  26259  F-box and WD repeat domain containing 8
AliasesFBW6; FBW8; FBX29; FBXO29; 
FBXW6
GeneCards (Weizmann)FBXW8
Ensembl hg19 (Hinxton)ENSG00000174989 [Gene_View]  chr12:117348761-117468953 [Contig_View]  FBXW8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174989 [Gene_View]  chr12:117348761-117468953 [Contig_View]  FBXW8 [Vega]
ICGC DataPortalENSG00000174989
TCGA cBioPortalFBXW8
AceView (NCBI)FBXW8
Genatlas (Paris)FBXW8
WikiGenes26259
SOURCE (Princeton)FBXW8
Genetics Home Reference (NIH)FBXW8
Genomic and cartography
GoldenPath hg19 (UCSC)FBXW8  -     chr12:117348761-117468953 +  12q24.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FBXW8  -     12q24.22   [Description]    (hg38-Dec_2013)
EnsemblFBXW8 - 12q24.22 [CytoView hg19]  FBXW8 - 12q24.22 [CytoView hg38]
Mapping of homologs : NCBIFBXW8 [Mapview hg19]  FBXW8 [Mapview hg38]
OMIM609073   
Gene and transcription
Genbank (Entrez)AF176707 AK055849 AK289621 BC037296 BC045190
RefSeq transcript (Entrez)NM_012174 NM_153348
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_029419 NW_004929385
Consensus coding sequences : CCDS (NCBI)FBXW8
Cluster EST : UnigeneHs.696428 [ NCBI ]
CGAP (NCI)Hs.696428
Alternative Splicing GalleryENSG00000174989
Gene ExpressionFBXW8 [ NCBI-GEO ]   FBXW8 [ EBI - ARRAY_EXPRESS ]   FBXW8 [ SEEK ]   FBXW8 [ MEM ]
Gene Expression Viewer (FireBrowse)FBXW8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26259
GTEX Portal (Tissue expression)FBXW8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3Y1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3Y1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3Y1
Splice isoforms : SwissVarQ8N3Y1
PhosPhoSitePlusQ8N3Y1
Domaine pattern : Prosite (Expaxy)FBOX (PS50181)    WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)F-box_dom    Quinoprotein_ADH-like_supfam    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)F-box-like (PF12937)   
Domain families : Pfam (NCBI)pfam12937   
Domain families : Smart (EMBL)FBOX (SM00256)  WD40 (SM00320)  
Conserved Domain (NCBI)FBXW8
DMDM Disease mutations26259
Blocks (Seattle)FBXW8
SuperfamilyQ8N3Y1
Human Protein AtlasENSG00000174989
Peptide AtlasQ8N3Y1
HPRD16427
IPIIPI00166657   IPI00384859   IPI00746482   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3Y1
IntAct (EBI)Q8N3Y1
FunCoupENSG00000174989
BioGRIDFBXW8
STRING (EMBL)FBXW8
ZODIACFBXW8
Ontologies - Pathways
QuickGOQ8N3Y1
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  cytoplasm  Golgi apparatus  Golgi organization  Golgi organization  cell proliferation  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  Cul7-RING ubiquitin ligase complex  perinuclear region of cytoplasm  positive regulation of dendrite morphogenesis  positive regulation of dendrite morphogenesis  spongiotrophoblast layer development  labyrinthine layer blood vessel development  3M complex  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  cytoplasm  Golgi apparatus  Golgi organization  Golgi organization  cell proliferation  protein ubiquitination  protein ubiquitination  SCF ubiquitin ligase complex  Cul7-RING ubiquitin ligase complex  perinuclear region of cytoplasm  positive regulation of dendrite morphogenesis  positive regulation of dendrite morphogenesis  spongiotrophoblast layer development  labyrinthine layer blood vessel development  3M complex  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkFBXW8
Atlas of Cancer Signalling NetworkFBXW8
Wikipedia pathwaysFBXW8
Orthology - Evolution
OrthoDB26259
GeneTree (enSembl)ENSG00000174989
Phylogenetic Trees/Animal Genes : TreeFamFBXW8
HOVERGENQ8N3Y1
HOGENOMQ8N3Y1
Homologs : HomoloGeneFBXW8
Homology/Alignments : Family Browser (UCSC)FBXW8
Gene fusions - Rearrangements
Fusion : MitelmanFBXW8/CHST11 [12q24.22/12q23.3]  
Fusion : MitelmanULK1/FBXW8 [12q24.33/12q24.22]  [t(12;12)(q24;q24)]  
Fusion: TCGAFBXW8 12q24.22 CHST11 12q23.3 BRCA
Fusion: TCGAULK1 12q24.33 FBXW8 12q24.22 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFBXW8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FBXW8
dbVarFBXW8
ClinVarFBXW8
1000_GenomesFBXW8 
Exome Variant ServerFBXW8
ExAC (Exome Aggregation Consortium)FBXW8 (select the gene name)
Genetic variants : HAPMAP26259
Genomic Variants (DGV)FBXW8 [DGVbeta]
DECIPHER (Syndromes)12:117348761-117468953  ENSG00000174989
CONAN: Copy Number AnalysisFBXW8 
Mutations
ICGC Data PortalFBXW8 
TCGA Data PortalFBXW8 
Broad Tumor PortalFBXW8
OASIS PortalFBXW8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFBXW8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFBXW8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FBXW8
DgiDB (Drug Gene Interaction Database)FBXW8
DoCM (Curated mutations)FBXW8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FBXW8 (select a term)
intoGenFBXW8
Cancer3DFBXW8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609073   
Orphanet
MedgenFBXW8
Genetic Testing Registry FBXW8
NextProtQ8N3Y1 [Medical]
TSGene26259
GENETestsFBXW8
Huge Navigator FBXW8 [HugePedia]
snp3D : Map Gene to Disease26259
BioCentury BCIQFBXW8
ClinGenFBXW8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26259
Chemical/Pharm GKB GenePA28039
Clinical trialFBXW8
Miscellaneous
canSAR (ICR)FBXW8 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFBXW8
EVEXFBXW8
GoPubMedFBXW8
iHOPFBXW8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:01:03 CEST 2017

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