FCER1A (Fc fragment of IgE receptor Ia)

2007-02-01 Affiliation

Identity

HGNC

FCER1A

LOCATION

1q23.2

LOCUSID

2205

ALIAS

FCE1A,FcERI

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2205
MIM: 147140
HGNC: 3609
Ensembl: ENSG00000179639

Variants:

dbSNP: 2205
ClinVar: 2205
TCGA: ENSG00000179639
COSMIC: FCER1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179639	ENST00000368114	E9PRN1
ENSG00000179639	ENST00000368115	P12319

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fc epsilon RI signaling pathway	KEGG	ko04664
Asthma	KEGG	ko05310
Fc epsilon RI signaling pathway	KEGG	hsa04664
Asthma	KEGG	hsa05310
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164776964	desloratadine	Chemical	ClinicalAnnotation	associated	PD	25412950
PA166129535	mizolastine	Chemical	ClinicalAnnotation	associated	PD	25412950
PA445999	Urticaria	Disease	ClinicalAnnotation	associated	PD	25412950

References

Pubmed ID	Year	Title	Citations
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
20410486	2010	Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells.	97
18846228	2008	Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.	86
18846228	2008	Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.	86
15217825	2004	Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells.	57
21516097	2011	Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcɛRI.	48
16237063	2005	TLR9- and FcepsilonRI-mediated responses oppose one another in plasmacytoid dendritic cells by down-regulating receptor expression.	45
13129935	2003	The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase.	42
18036650	2008	Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.	40
18356810	2008	Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies.	32

Citation

Dessen P

FCER1A (Fc fragment of IgE receptor Ia)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45948/fcer1a