FCGR1A (Fc fragment of IgG receptor Ia)

2013-05-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
CD64,CD64A,FCRI,IGFR1

Other Information

Locus ID:

NCBI: 2209
MIM: 146760
HGNC: 3613
Ensembl: ENSG00000150337

Variants:

dbSNP: 2209
ClinVar: 2209
TCGA: ENSG00000150337
COSMIC: FCGR1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150337ENST00000369168P12314
ENSG00000150337ENST00000444948C9JSN8

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Systemic lupus erythematosusKEGGko05322
Hematopoietic cell lineageKEGGhsa04640
Systemic lupus erythematosusKEGGhsa05322
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing-Cross presentationREACTOMER-HSA-1236975
Cross-presentation of soluble exogenous antigens (endosomes)REACTOMER-HSA-1236978
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

References

Pubmed IDYearTitleCitations
236973682013General mechanism for modulating immunoglobulin effector function.74
175115162007The importance of human FcgammaRI in mediating protection to malaria.56
213252192011Functional characteristics of the high affinity IgG receptor, FcγRI.52
170056902006Differential enhancement of dengue virus immune complex infectivity mediated by signaling-competent and signaling-incompetent human Fcgamma RIA (CD64) or FcgammaRIIA (CD32).41
200807252010Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells.39
155283662004Involvement of Fc gamma RI (CD64) in the mechanism of HIV-1 inhibition by polyclonal IgG purified from infected patients in cultured monocyte-derived macrophages.36
259256962015Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI.35
242059132014Differential gene expression of activating Fcγ receptor classifies active tuberculosis regardless of human immunodeficiency virus status or ethnicity.32
158788712005Analysis of binding sites in human C-reactive protein for Fc{gamma}RI, Fc{gamma}RIIA, and C1q by site-directed mutagenesis.31
212397142011An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity.31

Citation

Dessen P

FCGR1A (Fc fragment of IgG receptor Ia)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53298/fcgr1a