FCGR2C (Fc fragment of IgG receptor IIc (gene/pseudogene))

2011-05-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
CD32,CD32C,CDW32,FCG2,FCRIIC,IGFR2

Other Information

Locus ID:

NCBI: 9103
MIM: 612169
HGNC: 15626

Variants:

dbSNP: 9103
ClinVar: 9103
COSMIC: FCGR2C

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
FCGR activationREACTOMER-HSA-2029481
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
178273952008Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura.66
193096902009Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.58
251053672014FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.54
205080372010Copy number, linkage disequilibrium and disease association in the FCGR locus.51
221989512012Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles.39
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
232612992013Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.21
243531582013Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses.20
261332752015Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.12
237783242013FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response.11

Citation

Dessen P

FCGR2C (Fc fragment of IgG receptor IIc (gene/pseudogene))

Atlas Genet Cytogenet Oncol Haematol. 2011-05-01

Online version: http://atlasgeneticsoncology.org/gene/52219/fcgr2c