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FCGR3A (Fc fragment of IgG receptor IIIa)

Identity

Alias_namesFCGR3
FCG3
Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Alias_symbol (synonym)CD16
CD16a
Other aliasCD16A
FCGRIII
FCR-10
FCRIII
FCRIIIA
IGFR3
IMD20
HGNC (Hugo) FCGR3A
LocusID (NCBI) 2214
Atlas_Id 49750
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161541761 and ends at 161550103 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LOC100506548 (5p13.1) / FCGR3A (1q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FCGR3A   3619
LRG (Locus Reference Genomic)LRG_60
Cards
Entrez_Gene (NCBI)FCGR3A  2214  Fc fragment of IgG receptor IIIa
AliasesCD16; CD16A; FCG3; FCGR3; 
FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20
GeneCards (Weizmann)FCGR3A
Ensembl hg19 (Hinxton)ENSG00000203747 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000203747 [Gene_View]  chr1:161541761-161550103 [Contig_View]  FCGR3A [Vega]
ICGC DataPortalENSG00000203747
TCGA cBioPortalFCGR3A
AceView (NCBI)FCGR3A
Genatlas (Paris)FCGR3A
WikiGenes2214
SOURCE (Princeton)FCGR3A
Genetics Home Reference (NIH)FCGR3A
Genomic and cartography
GoldenPath hg38 (UCSC)FCGR3A  -     chr1:161541761-161550103 -  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCGR3A  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblFCGR3A - 1q23.3 [CytoView hg19]  FCGR3A - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIFCGR3A [Mapview hg19]  FCGR3A [Mapview hg38]
OMIM146740   615707   
Gene and transcription
Genbank (Entrez)AK223268 AK223295 AK302126 BC017865 BC033678
RefSeq transcript (Entrez)NM_000569 NM_001127592 NM_001127593 NM_001127595 NM_001127596 NM_001329120 NM_001329122
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCGR3A
Cluster EST : UnigeneHs.372679 [ NCBI ]
CGAP (NCI)Hs.372679
Alternative Splicing GalleryENSG00000203747
Gene ExpressionFCGR3A [ NCBI-GEO ]   FCGR3A [ EBI - ARRAY_EXPRESS ]   FCGR3A [ SEEK ]   FCGR3A [ MEM ]
Gene Expression Viewer (FireBrowse)FCGR3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2214
GTEX Portal (Tissue expression)FCGR3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08637   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP08637  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08637
Splice isoforms : SwissVarP08637
PhosPhoSitePlusP08637
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)Ig_2 (PF13895)   
Domain families : Pfam (NCBI)pfam13895   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)FCGR3A
DMDM Disease mutations2214
Blocks (Seattle)FCGR3A
PDB (SRS)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
PDB (PDBSum)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
PDB (IMB)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
PDB (RSDB)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
Structural Biology KnowledgeBase3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
SCOP (Structural Classification of Proteins)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
CATH (Classification of proteins structures)3AY4    3SGJ    3SGK    3WN5    5BW7    5D6D   
SuperfamilyP08637
Human Protein AtlasENSG00000203747
Peptide AtlasP08637
HPRD00903
IPIIPI00218834   IPI00853533   IPI00895917   IPI00640044   
Protein Interaction databases
DIP (DOE-UCLA)P08637
IntAct (EBI)P08637
FunCoupENSG00000203747
BioGRIDFCGR3A
STRING (EMBL)FCGR3A
ZODIACFCGR3A
Ontologies - Pathways
QuickGOP08637
Ontology : AmiGOplasma membrane  immune response  external side of plasma membrane  integral component of membrane  IgG binding  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of immune response  extracellular exosome  
Ontology : EGO-EBIplasma membrane  immune response  external side of plasma membrane  integral component of membrane  IgG binding  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of immune response  extracellular exosome  
Pathways : KEGG   
NDEx NetworkFCGR3A
Atlas of Cancer Signalling NetworkFCGR3A
Wikipedia pathwaysFCGR3A
Orthology - Evolution
OrthoDB2214
GeneTree (enSembl)ENSG00000203747
Phylogenetic Trees/Animal Genes : TreeFamFCGR3A
HOVERGENP08637
HOGENOMP08637
Homologs : HomoloGeneFCGR3A
Homology/Alignments : Family Browser (UCSC)FCGR3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCGR3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCGR3A
dbVarFCGR3A
ClinVarFCGR3A
1000_GenomesFCGR3A 
Exome Variant ServerFCGR3A
ExAC (Exome Aggregation Consortium)FCGR3A (select the gene name)
Genetic variants : HAPMAP2214
Genomic Variants (DGV)FCGR3A [DGVbeta]
DECIPHERFCGR3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCGR3A 
Mutations
ICGC Data PortalFCGR3A 
TCGA Data PortalFCGR3A 
Broad Tumor PortalFCGR3A
OASIS PortalFCGR3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFCGR3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFCGR3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCGR3A
DgiDB (Drug Gene Interaction Database)FCGR3A
DoCM (Curated mutations)FCGR3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCGR3A (select a term)
intoGenFCGR3A
Cancer3DFCGR3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM146740    615707   
Orphanet23351   
MedgenFCGR3A
Genetic Testing Registry FCGR3A
NextProtP08637 [Medical]
TSGene2214
GENETestsFCGR3A
Huge Navigator FCGR3A [HugePedia]
snp3D : Map Gene to Disease2214
BioCentury BCIQFCGR3A
ClinGenFCGR3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2214
Chemical/Pharm GKB GenePA28065
Clinical trialFCGR3A
Miscellaneous
canSAR (ICR)FCGR3A (select the gene name)
Probes
Litterature
PubMed376 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCGR3A
EVEXFCGR3A
GoPubMedFCGR3A
iHOPFCGR3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:15:46 CEST 2017

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