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FCHO2 (FCH domain only 2)

Identity

Other alias-
HGNC (Hugo) FCHO2
LocusID (NCBI) 115548
Atlas_Id 53000
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 72955981 and ends at 73090522 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLTC (17q23.1) / FCHO2 (5q13.2)ETV6 (12p13.2) / FCHO2 (5q13.2)FCHO2 (5q13.2) / CSH1 (17q23.3)
FCHO2 (5q13.2) / FCHO2 (5q13.2)FCHO2 (5q13.2) / ZNF271P (18q12.2)GART (21q22.11) / FCHO2 (5q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q13) ETV6/BAZ2A


External links

Nomenclature
HGNC (Hugo)FCHO2   25180
Cards
Entrez_Gene (NCBI)FCHO2  115548  FCH domain only 2
Aliases
GeneCards (Weizmann)FCHO2
Ensembl hg19 (Hinxton)ENSG00000157107 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157107 [Gene_View]  chr5:72955981-73090522 [Contig_View]  FCHO2 [Vega]
ICGC DataPortalENSG00000157107
TCGA cBioPortalFCHO2
AceView (NCBI)FCHO2
Genatlas (Paris)FCHO2
WikiGenes115548
SOURCE (Princeton)FCHO2
Genetics Home Reference (NIH)FCHO2
Genomic and cartography
GoldenPath hg38 (UCSC)FCHO2  -     chr5:72955981-73090522 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCHO2  -     5q13.2   [Description]    (hg19-Feb_2009)
EnsemblFCHO2 - 5q13.2 [CytoView hg19]  FCHO2 - 5q13.2 [CytoView hg38]
Mapping of homologs : NCBIFCHO2 [Mapview hg19]  FCHO2 [Mapview hg38]
OMIM613438   
Gene and transcription
Genbank (Entrez)AK291782 AK293796 AK295141 AL831971 AL832928
RefSeq transcript (Entrez)NM_001146032 NM_138782
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCHO2
Cluster EST : UnigeneHs.165762 [ NCBI ]
CGAP (NCI)Hs.165762
Alternative Splicing GalleryENSG00000157107
Gene ExpressionFCHO2 [ NCBI-GEO ]   FCHO2 [ EBI - ARRAY_EXPRESS ]   FCHO2 [ SEEK ]   FCHO2 [ MEM ]
Gene Expression Viewer (FireBrowse)FCHO2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115548
GTEX Portal (Tissue expression)FCHO2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ0JRZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ0JRZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ0JRZ9
Splice isoforms : SwissVarQ0JRZ9
PhosPhoSitePlusQ0JRZ9
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    MHD (PS51072)   
Domains : Interpro (EBI)F_BAR    FCH_dom    FCHo2    MHD    Muniscin_C   
Domain families : Pfam (Sanger)FCH (PF00611)    muHD (PF10291)   
Domain families : Pfam (NCBI)pfam00611    pfam10291   
Domain families : Smart (EMBL)FCH (SM00055)  
Conserved Domain (NCBI)FCHO2
DMDM Disease mutations115548
Blocks (Seattle)FCHO2
PDB (SRS)2V0O   
PDB (PDBSum)2V0O   
PDB (IMB)2V0O   
PDB (RSDB)2V0O   
Structural Biology KnowledgeBase2V0O   
SCOP (Structural Classification of Proteins)2V0O   
CATH (Classification of proteins structures)2V0O   
SuperfamilyQ0JRZ9
Human Protein AtlasENSG00000157107
Peptide AtlasQ0JRZ9
HPRD13319
IPIIPI00472794   IPI01013123   IPI00929732   IPI00966026   IPI00060416   
Protein Interaction databases
DIP (DOE-UCLA)Q0JRZ9
IntAct (EBI)Q0JRZ9
FunCoupENSG00000157107
BioGRIDFCHO2
STRING (EMBL)FCHO2
ZODIACFCHO2
Ontologies - Pathways
QuickGOQ0JRZ9
Ontology : AmiGOphosphatidylserine binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytosol  plasma membrane  clathrin-coated pit  membrane invagination  clathrin-coated vesicle  phosphatidylinositol binding  clathrin coat assembly  synaptic vesicle endocytosis  membrane organization  clathrin-dependent endocytosis  protein localization to plasma membrane  presynaptic endocytic zone membrane  
Ontology : EGO-EBIphosphatidylserine binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  cytosol  plasma membrane  clathrin-coated pit  membrane invagination  clathrin-coated vesicle  phosphatidylinositol binding  clathrin coat assembly  synaptic vesicle endocytosis  membrane organization  clathrin-dependent endocytosis  protein localization to plasma membrane  presynaptic endocytic zone membrane  
NDEx NetworkFCHO2
Atlas of Cancer Signalling NetworkFCHO2
Wikipedia pathwaysFCHO2
Orthology - Evolution
OrthoDB115548
GeneTree (enSembl)ENSG00000157107
Phylogenetic Trees/Animal Genes : TreeFamFCHO2
HOVERGENQ0JRZ9
HOGENOMQ0JRZ9
Homologs : HomoloGeneFCHO2
Homology/Alignments : Family Browser (UCSC)FCHO2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCHO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCHO2
dbVarFCHO2
ClinVarFCHO2
1000_GenomesFCHO2 
Exome Variant ServerFCHO2
ExAC (Exome Aggregation Consortium)FCHO2 (select the gene name)
Genetic variants : HAPMAP115548
Genomic Variants (DGV)FCHO2 [DGVbeta]
DECIPHERFCHO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCHO2 
Mutations
ICGC Data PortalFCHO2 
TCGA Data PortalFCHO2 
Broad Tumor PortalFCHO2
OASIS PortalFCHO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFCHO2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFCHO2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCHO2
DgiDB (Drug Gene Interaction Database)FCHO2
DoCM (Curated mutations)FCHO2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCHO2 (select a term)
intoGenFCHO2
Cancer3DFCHO2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613438   
Orphanet
MedgenFCHO2
Genetic Testing Registry FCHO2
NextProtQ0JRZ9 [Medical]
TSGene115548
GENETestsFCHO2
Huge Navigator FCHO2 [HugePedia]
snp3D : Map Gene to Disease115548
BioCentury BCIQFCHO2
ClinGenFCHO2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115548
Chemical/Pharm GKB GenePA134911830
Clinical trialFCHO2
Miscellaneous
canSAR (ICR)FCHO2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCHO2
EVEXFCHO2
GoPubMedFCHO2
iHOPFCHO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:15:47 CEST 2017

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