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FCN1 (ficolin 1)

Identity

Alias_namesficolin (collagen/fibrinogen domain-containing) 1
ficolin (collagen/fibrinogen domain containing) 1
Alias_symbol (synonym)FCNM
Other alias
HGNC (Hugo) FCN1
LocusID (NCBI) 2219
Atlas_Id 52302
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 134903236 and ends at 134918003 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
KIAA1217 (10p12.2) / FCN1 (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FCN1   3623
Cards
Entrez_Gene (NCBI)FCN1  2219  ficolin 1
AliasesFCNM
GeneCards (Weizmann)FCN1
Ensembl hg19 (Hinxton)ENSG00000085265 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085265 [Gene_View]  chr9:134903236-134918003 [Contig_View]  FCN1 [Vega]
ICGC DataPortalENSG00000085265
TCGA cBioPortalFCN1
AceView (NCBI)FCN1
Genatlas (Paris)FCN1
WikiGenes2219
SOURCE (Princeton)FCN1
Genetics Home Reference (NIH)FCN1
Genomic and cartography
GoldenPath hg38 (UCSC)FCN1  -     chr9:134903236-134918003 -  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCN1  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblFCN1 - 9q34.3 [CytoView hg19]  FCN1 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBIFCN1 [Mapview hg19]  FCN1 [Mapview hg38]
OMIM601252   
Gene and transcription
Genbank (Entrez)AK314867 AL833097 BC020635 BG482630 CR749452
RefSeq transcript (Entrez)NM_002003
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCN1
Cluster EST : UnigeneHs.638586 [ NCBI ]
CGAP (NCI)Hs.638586
Alternative Splicing GalleryENSG00000085265
Gene ExpressionFCN1 [ NCBI-GEO ]   FCN1 [ EBI - ARRAY_EXPRESS ]   FCN1 [ SEEK ]   FCN1 [ MEM ]
Gene Expression Viewer (FireBrowse)FCN1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2219
GTEX Portal (Tissue expression)FCN1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00602   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00602  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00602
Splice isoforms : SwissVarO00602
PhosPhoSitePlusO00602
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Collagen    Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_CS   
Domain families : Pfam (Sanger)Collagen (PF01391)    Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam01391    pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
Conserved Domain (NCBI)FCN1
DMDM Disease mutations2219
Blocks (Seattle)FCN1
PDB (SRS)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
PDB (PDBSum)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
PDB (IMB)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
PDB (RSDB)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
Structural Biology KnowledgeBase2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
SCOP (Structural Classification of Proteins)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
CATH (Classification of proteins structures)2D39    2JHH    2JHI    2JHK    2JHL    2JHM    2WNP   
SuperfamilyO00602
Human Protein AtlasENSG00000085265
Peptide AtlasO00602
HPRD03153
IPIIPI00012555   IPI00844468   IPI00163796   
Protein Interaction databases
DIP (DOE-UCLA)O00602
IntAct (EBI)O00602
FunCoupENSG00000085265
BioGRIDFCN1
STRING (EMBL)FCN1
ZODIACFCN1
Ontologies - Pathways
QuickGOO00602
Ontology : AmiGOG-protein coupled receptor binding  complement activation, lectin pathway  cell surface pattern recognition receptor signaling pathway  serine-type endopeptidase activity  protein binding  extracellular region  collagen trimer  proteolysis  complement activation  G-protein coupled receptor signaling pathway  signaling pattern recognition receptor activity  carbohydrate binding  extrinsic component of external side of plasma membrane  sialic acid binding  protein localization to cell surface  secretory granule lumen  neutrophil degranulation  recognition of apoptotic cell  negative regulation of viral entry into host cell  metal ion binding  ficolin-1-rich granule lumen  positive regulation of interleukin-8 secretion  
Ontology : EGO-EBIG-protein coupled receptor binding  complement activation, lectin pathway  cell surface pattern recognition receptor signaling pathway  serine-type endopeptidase activity  protein binding  extracellular region  collagen trimer  proteolysis  complement activation  G-protein coupled receptor signaling pathway  signaling pattern recognition receptor activity  carbohydrate binding  extrinsic component of external side of plasma membrane  sialic acid binding  protein localization to cell surface  secretory granule lumen  neutrophil degranulation  recognition of apoptotic cell  negative regulation of viral entry into host cell  metal ion binding  ficolin-1-rich granule lumen  positive regulation of interleukin-8 secretion  
NDEx NetworkFCN1
Atlas of Cancer Signalling NetworkFCN1
Wikipedia pathwaysFCN1
Orthology - Evolution
OrthoDB2219
GeneTree (enSembl)ENSG00000085265
Phylogenetic Trees/Animal Genes : TreeFamFCN1
HOVERGENO00602
HOGENOMO00602
Homologs : HomoloGeneFCN1
Homology/Alignments : Family Browser (UCSC)FCN1
Gene fusions - Rearrangements
Fusion : MitelmanKIAA1217/FCN1 [10p12.2/9q34.3]  [t(9;10)(q34;p12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCN1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCN1
dbVarFCN1
ClinVarFCN1
1000_GenomesFCN1 
Exome Variant ServerFCN1
ExAC (Exome Aggregation Consortium)FCN1 (select the gene name)
Genetic variants : HAPMAP2219
Genomic Variants (DGV)FCN1 [DGVbeta]
DECIPHERFCN1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCN1 
Mutations
ICGC Data PortalFCN1 
TCGA Data PortalFCN1 
Broad Tumor PortalFCN1
OASIS PortalFCN1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFCN1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFCN1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCN1
DgiDB (Drug Gene Interaction Database)FCN1
DoCM (Curated mutations)FCN1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCN1 (select a term)
intoGenFCN1
Cancer3DFCN1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601252   
Orphanet
MedgenFCN1
Genetic Testing Registry FCN1
NextProtO00602 [Medical]
TSGene2219
GENETestsFCN1
Huge Navigator FCN1 [HugePedia]
snp3D : Map Gene to Disease2219
BioCentury BCIQFCN1
ClinGenFCN1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2219
Chemical/Pharm GKB GenePA28069
Clinical trialFCN1
Miscellaneous
canSAR (ICR)FCN1 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCN1
EVEXFCN1
GoPubMedFCN1
iHOPFCN1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:15:48 CEST 2017

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