FCN1 (ficolin 1)

2011-08-01  

Identity

HGNC
FCN1
LOCATION
9q34.3
LOCUSID
2219
ALIAS
FCNM
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2219
MIM: 601252
HGNC: 3623
Ensembl: ENSG00000085265

Variants:

dbSNP: 2219
ClinVar: 2219
TCGA: ENSG00000085265
COSMIC: FCN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085265ENST00000371806O00602
ENSG00000085265ENST00000616356A0A087WVE2

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Lectin pathway of complement activationREACTOMER-HSA-166662
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceREACTOMER-HSA-2855086
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200324672010Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.39
203756342010Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma.37
163056432005M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement.30
214901562011M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules.28
238174112013Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
183434992008The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma.25
197411542009Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP.24
267923632016Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke.24
226733112012Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation.23

Citation

Dessen P

FCN1 (ficolin 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52302/fcn1