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FCN2 (ficolin 2)

Identity

Alias_namesficolin (collagen/fibrinogen domain-containing lectin) 2 (hucolin)
ficolin (collagen/fibrinogen domain containing lectin) 2
Alias_symbol (synonym)P35
FCNL
EBP-37
ficolin-2
Other alias
HGNC (Hugo) FCN2
LocusID (NCBI) 2220
Atlas_Id 53615
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 134880812 and ends at 134887520 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)FCN2   3624
Cards
Entrez_Gene (NCBI)FCN2  2220  ficolin 2
AliasesEBP-37; FCNL; P35; ficolin-2
GeneCards (Weizmann)FCN2
Ensembl hg19 (Hinxton)ENSG00000160339 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160339 [Gene_View]  chr9:134880812-134887520 [Contig_View]  FCN2 [Vega]
ICGC DataPortalENSG00000160339
TCGA cBioPortalFCN2
AceView (NCBI)FCN2
Genatlas (Paris)FCN2
WikiGenes2220
SOURCE (Princeton)FCN2
Genetics Home Reference (NIH)FCN2
Genomic and cartography
GoldenPath hg38 (UCSC)FCN2  -     chr9:134880812-134887520 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCN2  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblFCN2 - 9q34.3 [CytoView hg19]  FCN2 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBIFCN2 [Mapview hg19]  FCN2 [Mapview hg38]
OMIM601624   
Gene and transcription
Genbank (Entrez)AI052239 AK096112 AK290843 AK308476 BC069572
RefSeq transcript (Entrez)NM_004108 NM_015837 NM_015838 NM_015839
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCN2
Cluster EST : UnigeneHs.54517 [ NCBI ]
CGAP (NCI)Hs.54517
Alternative Splicing GalleryENSG00000160339
Gene ExpressionFCN2 [ NCBI-GEO ]   FCN2 [ EBI - ARRAY_EXPRESS ]   FCN2 [ SEEK ]   FCN2 [ MEM ]
Gene Expression Viewer (FireBrowse)FCN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2220
GTEX Portal (Tissue expression)FCN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15485   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15485  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15485
Splice isoforms : SwissVarQ15485
PhosPhoSitePlusQ15485
Domaine pattern : Prosite (Expaxy)FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)   
Domains : Interpro (EBI)Collagen    Fibrinogen_a/b/g_C_1    Fibrinogen_a/b/g_C_2    Fibrinogen_a/b/g_C_dom    Fibrinogen_CS   
Domain families : Pfam (Sanger)Collagen (PF01391)    Fibrinogen_C (PF00147)   
Domain families : Pfam (NCBI)pfam01391    pfam00147   
Domain families : Smart (EMBL)FBG (SM00186)  
Conserved Domain (NCBI)FCN2
DMDM Disease mutations2220
Blocks (Seattle)FCN2
PDB (SRS)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
PDB (PDBSum)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
PDB (IMB)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
PDB (RSDB)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
Structural Biology KnowledgeBase2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
SCOP (Structural Classification of Proteins)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
CATH (Classification of proteins structures)2J0G    2J0H    2J0Y    2J1G    2J2P    2J3F    2J3G    2J3O    2J3U    2J61    4NYT    4R9J    4R9T   
SuperfamilyQ15485
Human Protein AtlasENSG00000160339
Peptide AtlasQ15485
HPRD03376
IPIIPI00025052   IPI00871650   
Protein Interaction databases
DIP (DOE-UCLA)Q15485
IntAct (EBI)Q15485
FunCoupENSG00000160339
BioGRIDFCN2
STRING (EMBL)FCN2
ZODIACFCN2
Ontologies - Pathways
QuickGOQ15485
Ontology : AmiGOcomplement activation, lectin pathway  complement activation, lectin pathway  antigen binding  serine-type endopeptidase activity  protein binding  extracellular region  collagen trimer  proteolysis  complement activation  opsonization  proteoglycan binding  recognition of apoptotic cell  metal ion binding  calcium-dependent protein binding  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  extracellular exosome  blood microparticle  mannan binding  
Ontology : EGO-EBIcomplement activation, lectin pathway  complement activation, lectin pathway  antigen binding  serine-type endopeptidase activity  protein binding  extracellular region  collagen trimer  proteolysis  complement activation  opsonization  proteoglycan binding  recognition of apoptotic cell  metal ion binding  calcium-dependent protein binding  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  extracellular exosome  blood microparticle  mannan binding  
NDEx NetworkFCN2
Atlas of Cancer Signalling NetworkFCN2
Wikipedia pathwaysFCN2
Orthology - Evolution
OrthoDB2220
GeneTree (enSembl)ENSG00000160339
Phylogenetic Trees/Animal Genes : TreeFamFCN2
HOVERGENQ15485
HOGENOMQ15485
Homologs : HomoloGeneFCN2
Homology/Alignments : Family Browser (UCSC)FCN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCN2
dbVarFCN2
ClinVarFCN2
1000_GenomesFCN2 
Exome Variant ServerFCN2
ExAC (Exome Aggregation Consortium)FCN2 (select the gene name)
Genetic variants : HAPMAP2220
Genomic Variants (DGV)FCN2 [DGVbeta]
DECIPHERFCN2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCN2 
Mutations
ICGC Data PortalFCN2 
TCGA Data PortalFCN2 
Broad Tumor PortalFCN2
OASIS PortalFCN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFCN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFCN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCN2
DgiDB (Drug Gene Interaction Database)FCN2
DoCM (Curated mutations)FCN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCN2 (select a term)
intoGenFCN2
Cancer3DFCN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601624   
Orphanet
MedgenFCN2
Genetic Testing Registry FCN2
NextProtQ15485 [Medical]
TSGene2220
GENETestsFCN2
Huge Navigator FCN2 [HugePedia]
snp3D : Map Gene to Disease2220
BioCentury BCIQFCN2
ClinGenFCN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2220
Chemical/Pharm GKB GenePA28070
Clinical trialFCN2
Miscellaneous
canSAR (ICR)FCN2 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCN2
EVEXFCN2
GoPubMedFCN2
iHOPFCN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:15:48 CEST 2017

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