FCN2 (ficolin 2)

2013-11-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
EBP-37,FCNL,P35,ficolin-2

Other Information

Locus ID:

NCBI: 2220
MIM: 601624
HGNC: 3624
Ensembl: ENSG00000160339

Variants:

dbSNP: 2220
ClinVar: 2220
TCGA: ENSG00000160339
COSMIC: FCN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160339ENST00000291744Q15485
ENSG00000160339ENST00000350339Q15485

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Creation of C4 and C2 activatorsREACTOMER-HSA-166786
Lectin pathway of complement activationREACTOMER-HSA-166662
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceREACTOMER-HSA-2855086

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10066duloxetineChemicalClinicalAnnotation, VariantAnnotationassociatedPD29407288
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29407288

References

Pubmed IDYearTitleCitations
147070972004L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement.64
196329902009Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition.62
153316012004L-ficolin is a pattern recognition molecule specific for acetyl groups.59
172158692007Structural insights into the innate immune recognition specificities of L- and H-ficolins.56
173860302007The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels.55
197289242009Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation.30
191091772009Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
194349122009Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.25
194349122009Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy.25

Citation

Dessen P

FCN2 (ficolin 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53615/fcn2