FCRL3 (Fc receptor like 3)

2008-10-01  

Identity

HGNC
FCRL3
LOCATION
1q23.1
LOCUSID
115352
ALIAS
CD307c,FCRH3,IFGP3,IRTA3,SPAP2

Other Information

Locus ID:

NCBI: 115352
MIM: 606510
HGNC: 18506
Ensembl: ENSG00000160856

Variants:

dbSNP: 115352
ClinVar: 115352
TCGA: ENSG00000160856
COSMIC: FCRL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160856ENST00000368184Q96P31
ENSG00000160856ENST00000368186Q96P31
ENSG00000160856ENST00000477837Q96P31
ENSG00000160856ENST00000485028Q96P31
ENSG00000160856ENST00000492769Q96P31
ENSG00000160856ENST00000496769R4GNJ6

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
257627852015Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells.40
198439362009FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
201901422010Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.26
194389042010Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease.24
172001622007Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association.21
172001622007Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association.21
194942752009Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.20
163848512006Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.18
163848512006Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.18

Citation

Dessen P

FCRL3 (Fc receptor like 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50413/fcrl3