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FCSK (fucose kinase)

Identity

Alias_namesFUK
fucokinase
Alias_symbol (synonym)FLJ39408
Other alias1110046B12Rik
CDGF2
HGNC (Hugo) FCSK
LocusID (NCBI) 197258
Atlas_Id 42914
Location 16q22.1  [Link to chromosome band 16q22]
Location_base_pair Starts at 70454595 and ends at 70480274 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FUK 16q22.1 / ABCB5 7p21.1
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0716p21q22ID107440


External links

Nomenclature
HGNC (Hugo)FCSK   29500
Cards
Entrez_Gene (NCBI)FCSK  197258  fucose kinase
Aliases1110046B12Rik; CDGF2; FUK
GeneCards (Weizmann)FCSK
Ensembl hg19 (Hinxton)ENSG00000157353 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157353 [Gene_View]  ENSG00000157353 [Sequence]  chr16:70454595-70480274 [Contig_View]  FCSK [Vega]
ICGC DataPortalENSG00000157353
TCGA cBioPortalFCSK
AceView (NCBI)FCSK
Genatlas (Paris)FCSK
WikiGenes197258
SOURCE (Princeton)FCSK
Genetics Home Reference (NIH)FCSK
Genomic and cartography
GoldenPath hg38 (UCSC)FCSK  -     chr16:70454595-70480274 +  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FCSK  -     -   [Description]    (hg19-Feb_2009)
GoldenPathFCSK - - [CytoView hg19]  FCSK - - [CytoView hg38]
ImmunoBaseENSG00000157353
Mapping of homologs : NCBIFCSK [Mapview hg19]  FCSK [Mapview hg38]
OMIM608675   618324   
Gene and transcription
Genbank (Entrez)AJ441184 AK056456 AK074168 AK092025 AK096727
RefSeq transcript (Entrez)NM_145059
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)FCSK
Cluster EST : UnigeneHs.7907 [ NCBI ]
CGAP (NCI)Hs.7907
Alternative Splicing GalleryENSG00000157353
Gene ExpressionFCSK [ NCBI-GEO ]   FCSK [ EBI - ARRAY_EXPRESS ]   FCSK [ SEEK ]   FCSK [ MEM ]
Gene Expression Viewer (FireBrowse)FCSK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)197258
GTEX Portal (Tissue expression)FCSK
Human Protein AtlasENSG00000157353-FCSK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N0W3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N0W3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N0W3
Splice isoforms : SwissVarQ8N0W3
Catalytic activity : Enzyme2.7.1.52 [ Enzyme-Expasy ]   2.7.1.522.7.1.52 [ IntEnz-EBI ]   2.7.1.52 [ BRENDA ]   2.7.1.52 [ KEGG ]   
PhosPhoSitePlusQ8N0W3
Domains : Interpro (EBI)Fucokinase    GHMP_kinase_C_dom    GHMP_kinase_C_sf    GHMP_kinase_N_dom    Ribosomal_S5_D2-typ_fold   
Domain families : Pfam (Sanger)Fucokinase (PF07959)    GHMP_kinases_C (PF08544)    GHMP_kinases_N (PF00288)   
Domain families : Pfam (NCBI)pfam07959    pfam08544    pfam00288   
Conserved Domain (NCBI)FCSK
DMDM Disease mutations197258
Blocks (Seattle)FCSK
SuperfamilyQ8N0W3
Human Protein Atlas [tissue]ENSG00000157353-FCSK [tissue]
Peptide AtlasQ8N0W3
HPRD16365
IPIIPI00418741   IPI00645739   IPI00909923   IPI01014315   IPI00432748   
Protein Interaction databases
DIP (DOE-UCLA)Q8N0W3
IntAct (EBI)Q8N0W3
FunCoupENSG00000157353
BioGRIDFCSK
STRING (EMBL)FCSK
ZODIACFCSK
Ontologies - Pathways
QuickGOQ8N0W3
Ontology : AmiGOATP binding  cytosol  GDP-L-fucose salvage  GDP-L-fucose salvage  carbohydrate phosphorylation  fucokinase activity  fucokinase activity  fucokinase activity  fucokinase activity  response to dopamine  
Ontology : EGO-EBIATP binding  cytosol  GDP-L-fucose salvage  GDP-L-fucose salvage  carbohydrate phosphorylation  fucokinase activity  fucokinase activity  fucokinase activity  fucokinase activity  response to dopamine  
NDEx NetworkFCSK
Atlas of Cancer Signalling NetworkFCSK
Wikipedia pathwaysFCSK
Orthology - Evolution
OrthoDB197258
GeneTree (enSembl)ENSG00000157353
Phylogenetic Trees/Animal Genes : TreeFamFCSK
HOGENOMQ8N0W3
Homologs : HomoloGeneFCSK
Homology/Alignments : Family Browser (UCSC)FCSK
Gene fusions - Rearrangements
Fusion : MitelmanFUK/ABCB5 [16q22.1/7p21.1]  
Fusion PortalFUK 16q22.1 ABCB5 7p21.1 PRAD
Fusion : QuiverFCSK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFCSK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FCSK
dbVarFCSK
ClinVarFCSK
1000_GenomesFCSK 
Exome Variant ServerFCSK
ExAC (Exome Aggregation Consortium)ENSG00000157353
GNOMAD BrowserENSG00000157353
Varsome BrowserFCSK
Genetic variants : HAPMAP197258
Genomic Variants (DGV)FCSK [DGVbeta]
DECIPHERFCSK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFCSK 
Mutations
ICGC Data PortalFCSK 
TCGA Data PortalFCSK 
Broad Tumor PortalFCSK
OASIS PortalFCSK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDFCSK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FCSK
DgiDB (Drug Gene Interaction Database)FCSK
DoCM (Curated mutations)FCSK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FCSK (select a term)
intoGenFCSK
Cancer3DFCSK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608675    618324   
Orphanet
DisGeNETFCSK
MedgenFCSK
Genetic Testing Registry FCSK
NextProtQ8N0W3 [Medical]
TSGene197258
GENETestsFCSK
Target ValidationFCSK
Huge Navigator FCSK [HugePedia]
snp3D : Map Gene to Disease197258
BioCentury BCIQFCSK
ClinGenFCSK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD197258
Chemical/Pharm GKB GenePA134863646
Clinical trialFCSK
Miscellaneous
canSAR (ICR)FCSK (select the gene name)
DataMed IndexFCSK
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFCSK
EVEXFCSK
GoPubMedFCSK
iHOPFCSK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 26 18:08:22 CEST 2019

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