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FDFT1 (farnesyl-diphosphate farnesyltransferase 1)

Identity

Other aliasDGPT
ERG9
SQS
SS
HGNC (Hugo) FDFT1
LocusID (NCBI) 2222
Atlas_Id 49724
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 11653082 and ends at 11696818 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGEF3 (3p14.3) / FDFT1 (8p23.1)FDFT1 (8p23.1) / ARHGAP31 (3q13.33)FDFT1 (8p23.1) / GATA4 (8p23.1)
FDFT1 (8p23.1) / INTS9 (8p21.1)FDFT1 (8p23.1) / NEIL2 (8p23.1)PCMTD1 (8q11.23) / FDFT1 (8p23.1)
PRPF18 (10p13) / FDFT1 (8p23.1)SMCO4 (11q21) / FDFT1 (8p23.1)ARHGEF3 3p14.3 / FDFT1 8p23.1
C11orf75 FDFT1 8p23.1FDFT1 8p23.1 / GATA4 8p23.1FDFT1 8p23.1 / INTS9 8p21.1
FDFT1 8p23.1 / NEIL2 8p23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)FDFT1   3629
Cards
Entrez_Gene (NCBI)FDFT1  2222  farnesyl-diphosphate farnesyltransferase 1
AliasesDGPT; ERG9; SQS; SS
GeneCards (Weizmann)FDFT1
Ensembl hg19 (Hinxton)ENSG00000079459 [Gene_View]  chr8:11653082-11696818 [Contig_View]  FDFT1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000079459 [Gene_View]  chr8:11653082-11696818 [Contig_View]  FDFT1 [Vega]
ICGC DataPortalENSG00000079459
TCGA cBioPortalFDFT1
AceView (NCBI)FDFT1
Genatlas (Paris)FDFT1
WikiGenes2222
SOURCE (Princeton)FDFT1
Genetics Home Reference (NIH)FDFT1
Genomic and cartography
GoldenPath hg19 (UCSC)FDFT1  -     chr8:11653082-11696818 +  8p23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)FDFT1  -     8p23.1   [Description]    (hg38-Dec_2013)
EnsemblFDFT1 - 8p23.1 [CytoView hg19]  FDFT1 - 8p23.1 [CytoView hg38]
Mapping of homologs : NCBIFDFT1 [Mapview hg19]  FDFT1 [Mapview hg38]
OMIM184420   
Gene and transcription
Genbank (Entrez)AA679352 AI679762 AK057726 AK098682 AK293545
RefSeq transcript (Entrez)NM_001287742 NM_001287743 NM_001287744 NM_001287745 NM_001287747 NM_001287748 NM_001287749 NM_001287750 NM_001287751 NM_001287756 NM_004462
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_077531 NW_004929336
Consensus coding sequences : CCDS (NCBI)FDFT1
Cluster EST : UnigeneHs.593928 [ NCBI ]
CGAP (NCI)Hs.593928
Alternative Splicing GalleryENSG00000079459
Gene ExpressionFDFT1 [ NCBI-GEO ]   FDFT1 [ EBI - ARRAY_EXPRESS ]   FDFT1 [ SEEK ]   FDFT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FDFT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2222
GTEX Portal (Tissue expression)FDFT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP37268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP37268
Splice isoforms : SwissVarP37268
Catalytic activity : Enzyme2.5.1.21 [ Enzyme-Expasy ]   2.5.1.212.5.1.21 [ IntEnz-EBI ]   2.5.1.21 [ BRENDA ]   2.5.1.21 [ KEGG ]   
PhosPhoSitePlusP37268
Domaine pattern : Prosite (Expaxy)SQUALEN_PHYTOEN_SYN_1 (PS01044)    SQUALEN_PHYTOEN_SYN_2 (PS01045)   
Domains : Interpro (EBI)Isoprenoid_synthase_dom    Squ/phyt_synthse    Squal_synth    Squalene/phytoene_synthase_CS   
Domain families : Pfam (Sanger)SQS_PSY (PF00494)   
Domain families : Pfam (NCBI)pfam00494   
Conserved Domain (NCBI)FDFT1
DMDM Disease mutations2222
Blocks (Seattle)FDFT1
PDB (SRS)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
PDB (PDBSum)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
PDB (IMB)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
PDB (RSDB)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
Structural Biology KnowledgeBase1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
SCOP (Structural Classification of Proteins)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
CATH (Classification of proteins structures)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA   
SuperfamilyP37268
Human Protein AtlasENSG00000079459
Peptide AtlasP37268
HPRD01694
IPIIPI00020944   IPI00909973   IPI00983445   IPI01015743   IPI00908715   IPI00789762   IPI01015028   IPI00976521   IPI01022304   IPI00977667   IPI01012882   IPI00981365   
Protein Interaction databases
DIP (DOE-UCLA)P37268
IntAct (EBI)P37268
FunCoupENSG00000079459
BioGRIDFDFT1
STRING (EMBL)FDFT1
ZODIACFDFT1
Ontologies - Pathways
QuickGOP37268
Ontology : AmiGOfarnesyl-diphosphate farnesyltransferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  isoprenoid biosynthetic process  integral component of membrane  oxidoreductase activity  farnesyl diphosphate metabolic process  squalene synthase activity  oxidation-reduction process  
Ontology : EGO-EBIfarnesyl-diphosphate farnesyltransferase activity  endoplasmic reticulum  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  isoprenoid biosynthetic process  integral component of membrane  oxidoreductase activity  farnesyl diphosphate metabolic process  squalene synthase activity  oxidation-reduction process  
Pathways : KEGGSteroid biosynthesis   
NDEx NetworkFDFT1
Atlas of Cancer Signalling NetworkFDFT1
Wikipedia pathwaysFDFT1
Orthology - Evolution
OrthoDB2222
GeneTree (enSembl)ENSG00000079459
Phylogenetic Trees/Animal Genes : TreeFamFDFT1
HOVERGENP37268
HOGENOMP37268
Homologs : HomoloGeneFDFT1
Homology/Alignments : Family Browser (UCSC)FDFT1
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF3/FDFT1 [3p14.3/8p23.1]  [t(3;8)(p14;p23)]  
Fusion : MitelmanFDFT1/GATA4 [8p23.1/8p23.1]  [t(8;8)(p23;p23)]  
Fusion : MitelmanFDFT1/INTS9 [8p23.1/8p21.1]  [t(8;8)(p21;p23)]  
Fusion : MitelmanFDFT1/NEIL2 [8p23.1/8p23.1]  [t(8;8)(p23;p23)]  
Fusion : MitelmanSMCO4/FDFT1 [11q21/8p23.1]  [t(8;11)(p23;q21)]  
Fusion: TCGAARHGEF3 3p14.3 FDFT1 8p23.1 PRAD
Fusion: TCGAC11orf75 FDFT1 8p23.1 PRAD
Fusion: TCGAFDFT1 8p23.1 GATA4 8p23.1 OV
Fusion: TCGAFDFT1 8p23.1 INTS9 8p21.1 BRCA
Fusion: TCGAFDFT1 8p23.1 NEIL2 8p23.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFDFT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FDFT1
dbVarFDFT1
ClinVarFDFT1
1000_GenomesFDFT1 
Exome Variant ServerFDFT1
ExAC (Exome Aggregation Consortium)FDFT1 (select the gene name)
Genetic variants : HAPMAP2222
Genomic Variants (DGV)FDFT1 [DGVbeta]
DECIPHER (Syndromes)8:11653082-11696818  ENSG00000079459
CONAN: Copy Number AnalysisFDFT1 
Mutations
ICGC Data PortalFDFT1 
TCGA Data PortalFDFT1 
Broad Tumor PortalFDFT1
OASIS PortalFDFT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFDFT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDFDFT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch FDFT1
DgiDB (Drug Gene Interaction Database)FDFT1
DoCM (Curated mutations)FDFT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)FDFT1 (select a term)
intoGenFDFT1
Cancer3DFDFT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM184420   
Orphanet
MedgenFDFT1
Genetic Testing Registry FDFT1
NextProtP37268 [Medical]
TSGene2222
GENETestsFDFT1
Huge Navigator FDFT1 [HugePedia]
snp3D : Map Gene to Disease2222
BioCentury BCIQFDFT1
ClinGenFDFT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2222
Chemical/Pharm GKB GenePA28073
Clinical trialFDFT1
Miscellaneous
canSAR (ICR)FDFT1 (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineFDFT1
EVEXFDFT1
GoPubMedFDFT1
iHOPFDFT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:05:58 CET 2017

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