FDFT1 (farnesyl-diphosphate farnesyltransferase 1)

2007-09-01  

Identity

HGNC
FDFT1
LOCATION
8p23.1
LOCUSID
2222
ALIAS
DGPT,ERG9,SQS,SQSD,SS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2222
MIM: 184420
HGNC: 3629
Ensembl: ENSG00000079459

Variants:

dbSNP: 2222
ClinVar: 2222
TCGA: ENSG00000079459
COSMIC: FDFT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079459ENST00000220584P37268
ENSG00000079459ENST00000220584Q6IAX1
ENSG00000079459ENST00000443614P37268
ENSG00000079459ENST00000525283E9PSH1
ENSG00000079459ENST00000525607E9PQ90
ENSG00000079459ENST00000525777P37268
ENSG00000079459ENST00000525900E9PNM1
ENSG00000079459ENST00000525954A0A1W2PQ47
ENSG00000079459ENST00000528643P37268
ENSG00000079459ENST00000528812P37268
ENSG00000079459ENST00000529464E9PNJ2
ENSG00000079459ENST00000530337E9PJG4
ENSG00000079459ENST00000530664P37268
ENSG00000079459ENST00000532266E9PS69
ENSG00000079459ENST00000538689P37268
ENSG00000079459ENST00000615631P37268
ENSG00000079459ENST00000615631Q6IAX1
ENSG00000079459ENST00000618539P37268
ENSG00000079459ENST00000618539Q6IAX1
ENSG00000079459ENST00000622850P37268
ENSG00000079459ENST00000623368P37268

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid biosynthesisKEGGko00100
Steroid biosynthesisKEGGhsa00100
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Cholesterol biosynthesisREACTOMER-HSA-191273
Regulation of cholesterol biosynthesis by SREBP (SREBF)REACTOMER-HSA-1655829
Activation of gene expression by SREBF (SREBP)REACTOMER-HSA-2426168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166848812006The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.121
207080052010Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.97
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
186763672008Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.47
205546942010Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption.45
194701682009NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.42
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32
204039972010Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.30
190540152009Squalene synthase: a critical enzyme in the cholesterol biosynthesis pathway.27
174835442007Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.26

Citation

Dessen P

FDFT1 (farnesyl-diphosphate farnesyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49724/fdft1