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FDFT1 (farnesyl-diphosphate farnesyltransferase 1)

Identity

Alias (NCBI)DGPT
ERG9
SQS
SQSD
SS
HGNC (Hugo) FDFT1
HGNC Alias symbSQS
HGNC Alias namesqualene synthase
LocusID (NCBI) 2222
Atlas_Id 49724
Location 8p23.1  [Link to chromosome band 8p23]
Location_base_pair Starts at 11802741 and ends at 11839298 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF3 (3p14.3) / FDFT1 (8p23.1)FDFT1 (8p23.1) / ARHGAP31 (3q13.33)FDFT1 (8p23.1) / GATA4 (8p23.1)
FDFT1 (8p23.1) / INTS9 (8p21.1)FDFT1 (8p23.1) / NEIL2 (8p23.1)PCMTD1 (8q11.23) / FDFT1 (8p23.1)
PRPF18 (10p13) / FDFT1 (8p23.1)SMCO4 (11q21) / FDFT1 (8p23.1)ARHGEF3 3p14.3 / FDFT1 8p23.1
C11orf75 FDFT1 8p23.1FDFT1 8p23.1 / GATA4 8p23.1FDFT1 8p23.1 / INTS9 8p21.1
FDFT1 8p23.1 / NEIL2 8p23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)FDFT1   3629
Cards
Entrez_Gene (NCBI)FDFT1    farnesyl-diphosphate farnesyltransferase 1
AliasesDGPT; ERG9; SQS; SQSD; 
SS
GeneCards (Weizmann)FDFT1
Ensembl hg19 (Hinxton)ENSG00000079459 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079459 [Gene_View]  ENSG00000079459 [Sequence]  chr8:11802741-11839298 [Contig_View]  FDFT1 [Vega]
ICGC DataPortalENSG00000079459
TCGA cBioPortalFDFT1
AceView (NCBI)FDFT1
Genatlas (Paris)FDFT1
SOURCE (Princeton)FDFT1
Genetics Home Reference (NIH)FDFT1
Genomic and cartography
GoldenPath hg38 (UCSC)FDFT1  -     chr8:11802741-11839298 +  8p23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)FDFT1  -     8p23.1   [Description]    (hg19-Feb_2009)
GoldenPathFDFT1 - 8p23.1 [CytoView hg19]  FDFT1 - 8p23.1 [CytoView hg38]
ImmunoBaseENSG00000079459
Genome Data Viewer NCBIFDFT1 [Mapview hg19]  
OMIM184420   618156   
Gene and transcription
Genbank (Entrez)AA679352 AI679762 AK057726 AK098682 AK293545
RefSeq transcript (Entrez)NM_001287742 NM_001287743 NM_001287744 NM_001287745 NM_001287747 NM_001287748 NM_001287749 NM_001287750 NM_001287751 NM_001287756 NM_004462
Consensus coding sequences : CCDS (NCBI)FDFT1
Gene ExpressionFDFT1 [ NCBI-GEO ]   FDFT1 [ EBI - ARRAY_EXPRESS ]   FDFT1 [ SEEK ]   FDFT1 [ MEM ]
Gene Expression Viewer (FireBrowse)FDFT1 [ Firebrowse - Broad ]
GenevisibleExpression of FDFT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2222
GTEX Portal (Tissue expression)FDFT1
Human Protein AtlasENSG00000079459-FDFT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP37268   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP37268  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP37268
PhosPhoSitePlusP37268
Domaine pattern : Prosite (Expaxy)SQUALEN_PHYTOEN_SYN_1 (PS01044)    SQUALEN_PHYTOEN_SYN_2 (PS01045)   
Domains : Interpro (EBI)Isoprenoid_synthase_dom_sf    Squ/phyt_synthse    Squal_synth-like    Squalene/phytoene_synthase_CS    Trans_IPPS_HH   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)FDFT1
PDB (RSDB)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
PDB Europe1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
PDB (PDBSum)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
PDB (IMB)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
Structural Biology KnowledgeBase1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
SCOP (Structural Classification of Proteins)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
CATH (Classification of proteins structures)1EZF    3ASX    3LEE    3Q2Z    3Q30    3V66    3VJ8    3VJ9    3VJA    3VJB    3VJC    3WC9    3WCD    3WCF    3WCH    3WCI    3WCJ    3WCL    3WCM    3WEF    3WEG    3WEH    3WEI    3WEJ    3WEK    3WSA    6PYJ    6PYV    6PYW    6PZ5   
SuperfamilyP37268
AlphaFold pdb e-kbP37268   
Human Protein Atlas [tissue]ENSG00000079459-FDFT1 [tissue]
HPRD01694
Protein Interaction databases
DIP (DOE-UCLA)P37268
IntAct (EBI)P37268
BioGRIDFDFT1
STRING (EMBL)FDFT1
ZODIACFDFT1
Ontologies - Pathways
QuickGOP37268
Ontology : AmiGOfarnesyl-diphosphate farnesyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  integral component of membrane  regulation of lipid metabolic process  regulation of metabolic process  farnesyl diphosphate metabolic process  metal ion binding  squalene synthase activity  
Ontology : EGO-EBIfarnesyl-diphosphate farnesyltransferase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  endoplasmic reticulum membrane  endoplasmic reticulum membrane  steroid biosynthetic process  cholesterol biosynthetic process  cholesterol biosynthetic process  integral component of membrane  regulation of lipid metabolic process  regulation of metabolic process  farnesyl diphosphate metabolic process  metal ion binding  squalene synthase activity  
Pathways : KEGGSteroid biosynthesis   
NDEx NetworkFDFT1
Atlas of Cancer Signalling NetworkFDFT1
Wikipedia pathwaysFDFT1
Orthology - Evolution
OrthoDB2222
GeneTree (enSembl)ENSG00000079459
Phylogenetic Trees/Animal Genes : TreeFamFDFT1
Homologs : HomoloGeneFDFT1
Homology/Alignments : Family Browser (UCSC)FDFT1
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF3/FDFT1 [3p14.3/8p23.1]  
Fusion : MitelmanFDFT1/GATA4 [8p23.1/8p23.1]  
Fusion : MitelmanFDFT1/INTS9 [8p23.1/8p21.1]  
Fusion : MitelmanFDFT1/NEIL2 [8p23.1/8p23.1]  
Fusion : MitelmanSMCO4/FDFT1 [11q21/8p23.1]  
Fusion : QuiverFDFT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerFDFT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)FDFT1
dbVarFDFT1
ClinVarFDFT1
MonarchFDFT1
1000_GenomesFDFT1 
Exome Variant ServerFDFT1
GNOMAD BrowserENSG00000079459
Varsome BrowserFDFT1
ACMGFDFT1 variants
VarityP37268
Genomic Variants (DGV)FDFT1 [DGVbeta]
DECIPHERFDFT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisFDFT1 
Mutations
ICGC Data PortalFDFT1 
TCGA Data PortalFDFT1 
Broad Tumor PortalFDFT1
OASIS PortalFDFT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICFDFT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DFDFT1
Mutations and Diseases : HGMDFDFT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaFDFT1
DgiDB (Drug Gene Interaction Database)FDFT1
DoCM (Curated mutations)FDFT1
CIViC (Clinical Interpretations of Variants in Cancer)FDFT1
Cancer3DFDFT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM184420    618156   
Orphanet
DisGeNETFDFT1
MedgenFDFT1
Genetic Testing Registry FDFT1
NextProtP37268 [Medical]
GENETestsFDFT1
Target ValidationFDFT1
Huge Navigator FDFT1 [HugePedia]
ClinGenFDFT1
Clinical trials, drugs, therapy
MyCancerGenomeFDFT1
Protein Interactions : CTDFDFT1
Pharm GKB GenePA28073
Pharm GKB PathwaysPA154423660   PA2031   
PharosP37268
Clinical trialFDFT1
Miscellaneous
canSAR (ICR)FDFT1
HarmonizomeFDFT1
DataMed IndexFDFT1
Probes
Litterature
PubMed81 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXFDFT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:09:18 CEST 2021

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